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Age-Related Association between Apolipoprotein E ε4 and Cognitive Function in Japanese Patients with Alzheimer's Disease.

Nagata T, Shinagawa S, Kuerban B, Shibata N, Ohnuma T, Arai H, Nakayama K, Yamada H.

Dement Geriatr Cogn Dis Extra. 2013 Jan;3(1):66-73. doi: 10.1159/000348351. Epub 2013 Mar 8.


Association between white matter hyperintensity severity and cognitive impairment according to the presence of the apolipoprotein E (APOE) ε4 allele in the elderly: retrospective analysis of data from the CREDOS study.

Son SJ, Lee KS, Lee Y, Baek JH, Choi SH, Na DL, Seo SW, Oh BH, Hong CH.

J Clin Psychiatry. 2012 Dec;73(12):1555-62. doi: 10.4088/JCP.12m07702. Epub 2012 Oct 30.


Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect.

Caselli RJ, Dueck AC, Osborne D, Sabbagh MN, Connor DJ, Ahern GL, Baxter LC, Rapcsak SZ, Shi J, Woodruff BK, Locke DE, Snyder CH, Alexander GE, Rademakers R, Reiman EM.

N Engl J Med. 2009 Jul 16;361(3):255-63. doi: 10.1056/NEJMoa0809437.


APOE ε4 carriers may undergo synaptic damage conferring risk of Alzheimer's disease.

Sun X, Dong C, Levin B, Crocco E, Loewenstein D, Zetterberg H, Blennow K, Wright CB; Alzheimer's Disease Neuroimaging Initiative..

Alzheimers Dement. 2016 Nov;12(11):1159-1166. doi: 10.1016/j.jalz.2016.05.003. Epub 2016 Jun 16.


Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment.

Caselli RJ, Reiman EM, Locke DE, Hutton ML, Hentz JG, Hoffman-Snyder C, Woodruff BK, Alexander GE, Osborne D.

Arch Neurol. 2007 Sep;64(9):1306-11.


Inheritance of the ApoE epsilon4 allele increases the rate of brain atrophy in dementia patients.

Wahlund LO, Julin P, Lannfelt L, Lindqvist J, Svensson L.

Dement Geriatr Cogn Disord. 1999 Jul-Aug;10(4):262-8.


Association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and executive function in Japanese patients with Alzheimer's disease.

Nagata T, Shinagawa S, Nukariya K, Ochiai Y, Kawamura S, Agawa-Ohta M, Kasahara H, Nakayama K, Yamada H.

Psychogeriatrics. 2011 Sep;11(3):141-9. doi: 10.1111/j.1479-8301.2011.00364.x. Epub 2011 Jun 15.


APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease.

Zhou Q, Peng D, Yuan X, Lv Z, Pang S, Jiang W, Yang C, Shi X, Pang G, Yang Y, Xie H, Zhang W, Hu C, Yang Z.

Neural Regen Res. 2014 Mar 15;9(6):653-60. doi: 10.4103/1673-5374.130117.


Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease.

Lautner R, Palmqvist S, Mattsson N, Andreasson U, Wallin A, Pålsson E, Jakobsson J, Herukka SK, Owenius R, Olsson B, Hampel H, Rujescu D, Ewers M, Landén M, Minthon L, Blennow K, Zetterberg H, Hansson O; Alzheimer’s Disease Neuroimaging Initiative..

JAMA Psychiatry. 2014 Oct;71(10):1183-91. doi: 10.1001/jamapsychiatry.2014.1060.


The neuropsychology of normal aging and preclinical Alzheimer's disease.

Caselli RJ, Locke DE, Dueck AC, Knopman DS, Woodruff BK, Hoffman-Snyder C, Rademakers R, Fleisher AS, Reiman EM.

Alzheimers Dement. 2014 Jan;10(1):84-92. doi: 10.1016/j.jalz.2013.01.004. Epub 2013 Mar 26.


Effect of the apolipoprotein E epsilon4 allele on the efficacy and tolerability of galantamine in the treatment of Alzheimer's disease.

Suh GH, Jung HY, Lee CU, Oh BH, Lee SK, Lee N, Kim J, Kee BS, Ko D, Kim YH, Ju YS, Hong I, Choi S; Korean Galantamine Study Group..

Dement Geriatr Cogn Disord. 2006;21(1):33-9. Epub 2005 Oct 25.


Effect of APOE genotype status on targeted clinical trials outcomes and efficiency in dementia and mild cognitive impairment resulting from Alzheimer's disease.

Kennedy RE, Cutter GR, Schneider LS.

Alzheimers Dement. 2014 May;10(3):349-59. doi: 10.1016/j.jalz.2013.03.003. Epub 2013 May 25.


Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease.

Wolk DA, Dickerson BC; Alzheimer's Disease Neuroimaging Initiative..

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10256-61. doi: 10.1073/pnas.1001412107. Epub 2010 May 17.


Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment.

Devanand DP, Pelton GH, Zamora D, Liu X, Tabert MH, Goodkind M, Scarmeas N, Braun I, Stern Y, Mayeux R.

Arch Neurol. 2005 Jun;62(6):975-80.


Apolipoprotein E epsilon4 allele differentiates the clinical response to donepezil in Alzheimer's disease.

Bizzarro A, Marra C, Acciarri A, Valenza A, Tiziano FD, Brahe C, Masullo C.

Dement Geriatr Cogn Disord. 2005;20(4):254-61. Epub 2005 Aug 9.


Double-blind crossover study of the cognitive effects of lorazepam in healthy apolipoprotein E (APOE)-epsilon4 carriers.

Stonnington CM, Snyder PJ, Hentz JG, Reiman EM, Caselli RJ.

J Clin Psychiatry. 2009 Oct;70(10):1379-84. doi: 10.4088/JCP.08m04593. Epub 2009 Jun 30.


Assessment of Alzheimer's disease risk with functional magnetic resonance imaging: an arterial spin labeling study.

Bangen KJ, Restom K, Liu TT, Wierenga CE, Jak AJ, Salmon DP, Bondi MW.

J Alzheimers Dis. 2012;31 Suppl 3:S59-74.


Apolipoprotein epsilon4 and neuropsychological performance in Alzheimer's disease and vascular dementia.

McGuinness B, Carson R, Barrett SL, Craig D, Passmore AP.

Neurosci Lett. 2010 Oct 8;483(1):62-6. doi: 10.1016/j.neulet.2010.07.063. Epub 2010 Aug 1.


Apolipoprotein E epsilon4 allele is unrelated to cognitive or functional decline in Alzheimer's disease: retrospective and prospective analysis.

Kleiman T, Zdanys K, Black B, Rightmer T, Grey M, Garman K, Macavoy M, Gelernter J, van Dyck C.

Dement Geriatr Cogn Disord. 2006;22(1):73-82. Epub 2006 May 12.


Apolipoprotein E ε4 Modulates Cognitive Profiles, Hippocampal Volume, and Resting-State Functional Connectivity in Alzheimer's Disease.

Wang X, Wang J, He Y, Li H, Yuan H, Evans A, Yu X, He Y, Wang H.

J Alzheimers Dis. 2015;45(3):781-95. doi: 10.3233/JAD-142556.


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