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Ebola virus VP35 induces high-level production of recombinant TPL-2-ABIN-2-NF-κB1 p105 complex in co-transfected HEK-293 cells.

Gantke T, Boussouf S, Janzen J, Morrice NA, Howell S, Mühlberger E, Ley SC.

Biochem J. 2013 Jun 1;452(2):359-65. doi: 10.1042/BJ20121873.


ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.

Lang V, Symons A, Watton SJ, Janzen J, Soneji Y, Beinke S, Howell S, Ley SC.

Mol Cell Biol. 2004 Jun;24(12):5235-48.


Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection.

Besson B, Sonthonnax F, Duchateau M, Ben Khalifa Y, Larrous F, Eun H, Hourdel V, Matondo M, Chamot-Rooke J, Grailhe R, Bourhy H.

PLoS Pathog. 2017 Oct 30;13(10):e1006697. doi: 10.1371/journal.ppat.1006697. eCollection 2017 Oct.


Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.

Yang HT, Papoutsopoulou S, Belich M, Brender C, Janzen J, Gantke T, Handley M, Ley SC.

Mol Cell Biol. 2012 Sep;32(17):3438-51. doi: 10.1128/MCB.00564-12. Epub 2012 Jun 25.


TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105.

Belich MP, Salmerón A, Johnston LH, Ley SC.

Nature. 1999 Jan 28;397(6717):363-8.


NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity.

Beinke S, Deka J, Lang V, Belich MP, Walker PA, Howell S, Smerdon SJ, Gamblin SJ, Ley SC.

Mol Cell Biol. 2003 Jul;23(14):4739-52.


Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase.

Gantke T, Sriskantharajah S, Ley SC.

Cell Res. 2011 Jan;21(1):131-45. doi: 10.1038/cr.2010.173. Epub 2010 Dec 7. Review. Erratum in: Cell Res. 2011 Apr;21(4):704.


IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.

Handoyo H, Stafford MJ, McManus E, Baltzis D, Peggie M, Cohen P.

Biochem J. 2009 Oct 23;424(1):109-18. doi: 10.1042/BJ20091271. Retraction in: Biochem J. 2014 Jan 1;457(1):227.


IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400.

Roget K, Ben-Addi A, Mambole-Dema A, Gantke T, Yang HT, Janzen J, Morrice N, Abbott D, Ley SC.

Mol Cell Biol. 2012 Nov;32(22):4684-90. doi: 10.1128/MCB.01065-12. Epub 2012 Sep 17.


NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation.

Yang HT, Wang Y, Zhao X, Demissie E, Papoutsopoulou S, Mambole A, O'Garra A, Tomczak MF, Erdman SE, Fox JG, Ley SC, Horwitz BH.

J Immunol. 2011 Feb 15;186(4):1989-96. doi: 10.4049/jimmunol.1001003. Epub 2011 Jan 7.


NF-κB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-κB function.

Sun F, Qu Z, Xiao Y, Zhou J, Burns TF, Stabile LP, Siegfried JM, Xiao G.

Oncogene. 2016 May 5;35(18):2299-310. doi: 10.1038/onc.2015.299. Epub 2015 Aug 24.


IκB kinase regulation of the TPL-2/ERK MAPK pathway.

Gantke T, Sriskantharajah S, Sadowski M, Ley SC.

Immunol Rev. 2012 Mar;246(1):168-82. doi: 10.1111/j.1600-065X.2012.01104.x. Review.


ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling.

Verstrepen L, Carpentier I, Verhelst K, Beyaert R.

Biochem Pharmacol. 2009 Jul 15;78(2):105-14. doi: 10.1016/j.bcp.2009.02.009. Epub 2009 Feb 27. Review.


ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.

Papoutsopoulou S, Symons A, Tharmalingham T, Belich MP, Kaiser F, Kioussis D, O'Garra A, Tybulewicz V, Ley SC.

Nat Immunol. 2006 Jun;7(6):606-15. Epub 2006 Apr 23.


Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.

Robinson MJ, Beinke S, Kouroumalis A, Tsichlis PN, Ley SC.

Mol Cell Biol. 2007 Nov;27(21):7355-64. Epub 2007 Aug 20.


Basic residues within the ebolavirus VP35 protein are required for its viral polymerase cofactor function.

Prins KC, Binning JM, Shabman RS, Leung DW, Amarasinghe GK, Basler CF.

J Virol. 2010 Oct;84(20):10581-91. doi: 10.1128/JVI.00925-10. Epub 2010 Aug 4.


Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology.

Beinke S, Ley SC.

Biochem J. 2004 Sep 1;382(Pt 2):393-409. Review.

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