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Synaptic mechanisms underlying rapid antidepressant action of ketamine.

Kavalali ET, Monteggia LM.

Am J Psychiatry. 2012 Nov;169(11):1150-6. Review.


NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.

Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng PF, Kavalali ET, Monteggia LM.

Nature. 2011 Jun 15;475(7354):91-5. doi: 10.1038/nature10130.


A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action.

Naughton M, Clarke G, O'Leary OF, Cryan JF, Dinan TG.

J Affect Disord. 2014 Mar;156:24-35. doi: 10.1016/j.jad.2013.11.014. Epub 2013 Dec 10. Review.


The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine.

Monteggia LM, Gideons E, Kavalali ET.

Biol Psychiatry. 2013 Jun 15;73(12):1199-203. doi: 10.1016/j.biopsych.2012.09.006. Epub 2012 Oct 11. Review.


[Ketamine's antidepressant effect: focus on ketamine mechanisms of action].

De Maricourt P, Jay T, Goncalvès P, Lôo H, Gaillard R.

Encephale. 2014 Feb;40(1):48-55. doi: 10.1016/j.encep.2013.09.002. Epub 2014 Jan 13. Review. French.


How does ketamine elicit a rapid antidepressant response?

Kavalali ET, Monteggia LM.

Curr Opin Pharmacol. 2015 Feb;20:35-9. doi: 10.1016/j.coph.2014.11.005. Epub 2014 Nov 25. Review.


What is the mechanism of Ketamine's rapid-onset antidepressant effect? A concise overview of the surprisingly large number of possibilities.

Strasburger SE, Bhimani PM, Kaabe JH, Krysiak JT, Nanchanatt DL, Nguyen TN, Pough KA, Prince TA, Ramsey NS, Savsani KH, Scandlen L, Cavaretta MJ, Raffa RB.

J Clin Pharm Ther. 2017 Apr;42(2):147-154. doi: 10.1111/jcpt.12497. Epub 2017 Jan 22. Review.


Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses.

Gideons ES, Kavalali ET, Monteggia LM.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8649-54. doi: 10.1073/pnas.1323920111. Epub 2014 May 27.


Ketamine as a novel antidepressant: from synapse to behavior.

Murrough JW.

Clin Pharmacol Ther. 2012 Feb;91(2):303-9. doi: 10.1038/clpt.2011.244. Epub 2011 Dec 28. Review.


GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine.

Miller OH, Yang L, Wang CC, Hargroder EA, Zhang Y, Delpire E, Hall BJ.

Elife. 2014 Oct 23;3:e03581. doi: 10.7554/eLife.03581.


BDNF - a key transducer of antidepressant effects.

Björkholm C, Monteggia LM.

Neuropharmacology. 2016 Mar;102:72-9. doi: 10.1016/j.neuropharm.2015.10.034. Epub 2015 Nov 11. Review.


NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice.

Walker AK, Budac DP, Bisulco S, Lee AW, Smith RA, Beenders B, Kelley KW, Dantzer R.

Neuropsychopharmacology. 2013 Aug;38(9):1609-16. doi: 10.1038/npp.2013.71. Epub 2013 Mar 19.


Modulation of synaptic plasticity by stress and antidepressants.

Popoli M, Gennarelli M, Racagni G.

Bipolar Disord. 2002 Jun;4(3):166-82. Review.


A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists.

Duman RS, Li N.

Philos Trans R Soc Lond B Biol Sci. 2012 Sep 5;367(1601):2475-84. doi: 10.1098/rstb.2011.0357. Review.


mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.

Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, Li XY, Aghajanian G, Duman RS.

Science. 2010 Aug 20;329(5994):959-64. doi: 10.1126/science.1190287.


Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition.

Miller OH, Moran JT, Hall BJ.

Neuropharmacology. 2016 Jan;100:17-26. doi: 10.1016/j.neuropharm.2015.07.028. Epub 2015 Jul 26. Review.


Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds.

Niciu MJ, Henter ID, Luckenbaugh DA, Zarate CA Jr, Charney DS.

Annu Rev Pharmacol Toxicol. 2014;54:119-39. doi: 10.1146/annurev-pharmtox-011613-135950. Review.


Age dependence of the rapid antidepressant and synaptic effects of acute NMDA receptor blockade.

Nosyreva E, Autry AE, Kavalali ET, Monteggia LM.

Front Mol Neurosci. 2014 Dec 1;7:94. doi: 10.3389/fnmol.2014.00094. eCollection 2014.


GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine.

Liu RJ, Fuchikami M, Dwyer JM, Lepack AE, Duman RS, Aghajanian GK.

Neuropsychopharmacology. 2013 Oct;38(11):2268-77. doi: 10.1038/npp.2013.128. Epub 2013 May 17.


GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine.

Liu RJ, Duman C, Kato T, Hare B, Lopresto D, Bang E, Burgdorf J, Moskal J, Taylor J, Aghajanian G, Duman RS.

Neuropsychopharmacology. 2017 May;42(6):1231-1242. doi: 10.1038/npp.2016.202. Epub 2016 Sep 16.


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