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Items: 1 to 20 of 107

1.

mTORC2 controls actin polymerization required for consolidation of long-term memory.

Huang W, Zhu PJ, Zhang S, Zhou H, Stoica L, Galiano M, Krnjević K, Roman G, Costa-Mattioli M.

Nat Neurosci. 2013 Apr;16(4):441-8. doi: 10.1038/nn.3351. Epub 2013 Mar 3.

2.

mTORC1-S6K1 inhibition or mTORC2 activation improves hippocampal synaptic plasticity and learning in Angelman syndrome mice.

Sun J, Liu Y, Tran J, O'Neal P, Baudry M, Bi X.

Cell Mol Life Sci. 2016 Nov;73(22):4303-4314. Epub 2016 May 12.

3.

Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice.

Zhao Y, He L, Zhang Y, Zhao J, Liu Z, Xing F, Liu M, Feng Z, Li W, Zhang J.

J Steroid Biochem Mol Biol. 2017 Nov;174:96-113. doi: 10.1016/j.jsbmb.2017.08.003. Epub 2017 Aug 5.

PMID:
28789972
4.

mTORC2: actin on your memory.

Josselyn SA, Frankland PW.

Nat Neurosci. 2013 Apr;16(4):379-80. doi: 10.1038/nn.3362. No abstract available.

PMID:
23528935
5.

TORC2: a novel target for treating age-associated memory impairment.

Johnson JL, Huang W, Roman G, Costa-Mattioli M.

Sci Rep. 2015 Oct 22;5:15193. doi: 10.1038/srep15193.

6.

Rictor/mammalian target of rapamycin 2 regulates the development of Notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3.

Hua C, Guo H, Bu J, Zhou M, Cheng H, He F, Wang J, Wang X, Zhang Y, Wang Q, Zhou J, Cheng T, Xu M, Yuan W.

Exp Hematol. 2014 Dec;42(12):1031-40.e1-4. doi: 10.1016/j.exphem.2014.08.006. Epub 2014 Sep 6.

PMID:
25201756
7.

Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy.

Shende P, Xu L, Morandi C, Pentassuglia L, Heim P, Lebboukh S, Berthonneche C, Pedrazzini T, Kaufmann BA, Hall MN, Rüegg MA, Brink M.

Cardiovasc Res. 2016 Jan 1;109(1):103-14. doi: 10.1093/cvr/cvv252. Epub 2015 Nov 23.

PMID:
26598511
8.

Upregulation of CREB-mediated transcription enhances both short- and long-term memory.

Suzuki A, Fukushima H, Mukawa T, Toyoda H, Wu LJ, Zhao MG, Xu H, Shang Y, Endoh K, Iwamoto T, Mamiya N, Okano E, Hasegawa S, Mercaldo V, Zhang Y, Maeda R, Ohta M, Josselyn SA, Zhuo M, Kida S.

J Neurosci. 2011 Jun 15;31(24):8786-802. doi: 10.1523/JNEUROSCI.3257-10.2011.

9.

Brief report: the differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation.

Martin SK, Fitter S, Dutta AK, Matthews MP, Walkley CR, Hall MN, Ruegg MA, Gronthos S, Zannettino AC.

Stem Cells. 2015 Apr;33(4):1359-65. doi: 10.1002/stem.1931.

10.

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage.

Stoica L, Zhu PJ, Huang W, Zhou H, Kozma SC, Costa-Mattioli M.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3791-6. doi: 10.1073/pnas.1014715108. Epub 2011 Feb 9.

11.

Ampakines promote spine actin polymerization, long-term potentiation, and learning in a mouse model of Angelman syndrome.

Baudry M, Kramar E, Xu X, Zadran H, Moreno S, Lynch G, Gall C, Bi X.

Neurobiol Dis. 2012 Aug;47(2):210-5. doi: 10.1016/j.nbd.2012.04.002. Epub 2012 Apr 16.

12.

The integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory.

Giovannini MG, Lana D, Pepeu G.

Neurobiol Learn Mem. 2015 Mar;119:18-33. doi: 10.1016/j.nlm.2014.12.014. Epub 2015 Jan 13. Review.

PMID:
25595880
13.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.

14.

Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome.

Andrade-Talavera Y, Benito I, Casañas JJ, Rodríguez-Moreno A, Montesinos ML.

Neurobiol Dis. 2015 Oct;82:516-525. doi: 10.1016/j.nbd.2015.09.005. Epub 2015 Sep 24.

PMID:
26388397
15.

mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis.

Morrison MM, Young CD, Wang S, Sobolik T, Sanchez VM, Hicks DJ, Cook RS, Brantley-Sieders DM.

PLoS Genet. 2015 Jul 1;11(7):e1005291. doi: 10.1371/journal.pgen.1005291. eCollection 2015 Jul.

17.

Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo.

Tamura H, Ishikawa Y, Hino N, Maeda M, Yoshida S, Kaku S, Shiosaka S.

J Physiol. 2006 Feb 1;570(Pt 3):541-51. Epub 2005 Nov 24.

18.

Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory.

Guzowski JF, Lyford GL, Stevenson GD, Houston FP, McGaugh JL, Worley PF, Barnes CA.

J Neurosci. 2000 Jun 1;20(11):3993-4001.

19.

Systemic inhibition of mTOR kinase via rapamycin disrupts consolidation and reconsolidation of auditory fear memory.

Mac Callum PE, Hebert M, Adamec RE, Blundell J.

Neurobiol Learn Mem. 2014 Jul;112:176-85. doi: 10.1016/j.nlm.2013.08.014. Epub 2013 Sep 5.

PMID:
24012802
20.

Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors.

Carr TD, Feehan RP, Hall MN, Rüegg MA, Shantz LM.

Carcinogenesis. 2015 Apr;36(4):487-97. doi: 10.1093/carcin/bgv012. Epub 2015 Mar 4.

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