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Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis.

Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan M, Ferguson C, Fetrow JS.

PLoS One. 2013;8(1):e54633. doi: 10.1371/journal.pone.0054633. Epub 2013 Jan 28.


Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.

Gardiner MD, Vincent TL, Driscoll C, Burleigh A, Bou-Gharios G, Saklatvala J, Nagase H, Chanalaris A.

Osteoarthritis Cartilage. 2015 Apr;23(4):616-28. doi: 10.1016/j.joca.2014.12.014. Epub 2014 Dec 26.


Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice.

Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan MF, Ferguson CM, Chou J, Leng X, Fetrow JS.

Arthritis Rheum. 2012 Mar;64(3):705-17. doi: 10.1002/art.33388.


Integration of gene expression data with network-based analysis to identify signaling and metabolic pathways regulated during the development of osteoarthritis.

Olex AL, Turkett WH, Fetrow JS, Loeser RF.

Gene. 2014 May 25;542(1):38-45. doi: 10.1016/j.gene.2014.03.022. Epub 2014 Mar 12.


Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction.

Bateman JF, Rowley L, Belluoccio D, Chan B, Bell K, Fosang AJ, Little CB.

Arthritis Rheum. 2013 Jun;65(6):1547-60. doi: 10.1002/art.37900.


Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis.

Young AA, Smith MM, Smith SM, Cake MA, Ghosh P, Read RA, Melrose J, Sonnabend DH, Roughley PJ, Little CB.

Arthritis Res Ther. 2005;7(4):R852-61. Epub 2005 May 12.


Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms.

Jackson MT, Moradi B, Zaki S, Smith MM, McCracken S, Smith SM, Jackson CJ, Little CB.

Arthritis Rheumatol. 2014 Dec;66(12):3337-48. doi: 10.1002/art.38876.


Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.

Burleigh A, Chanalaris A, Gardiner MD, Driscoll C, Boruc O, Saklatvala J, Vincent TL.

Arthritis Rheum. 2012 Jul;64(7):2278-88. doi: 10.1002/art.34420.


Role of subchondral bone during early-stage experimental TMJ osteoarthritis.

Embree M, Ono M, Kilts T, Walker D, Langguth J, Mao J, Bi Y, Barth JL, Young M.

J Dent Res. 2011 Nov;90(11):1331-8. doi: 10.1177/0022034511421930. Epub 2011 Sep 13.


Global analyses of gene expression in early experimental osteoarthritis.

Appleton CT, Pitelka V, Henry J, Beier F.

Arthritis Rheum. 2007 Jun;56(6):1854-68.


Premature osteoarthritis in the Disproportionate micromelia (Dmm) mouse.

Bomsta BD, Bridgewater LC, Seegmiller RE.

Osteoarthritis Cartilage. 2006 May;14(5):477-85. Epub 2006 Jan 20.


Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, Shah M, Thompson EW.

Arthritis Rheum. 2009 Dec;60(12):3723-33. doi: 10.1002/art.25002.


Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints.

Pan J, Wang B, Li W, Zhou X, Scherr T, Yang Y, Price C, Wang L.

Bone. 2012 Aug;51(2):212-7. doi: 10.1016/j.bone.2011.11.030. Epub 2011 Dec 16.


Melanocortin 1 receptor-signaling deficiency results in an articular cartilage phenotype and accelerates pathogenesis of surgically induced murine osteoarthritis.

Lorenz J, Seebach E, Hackmayer G, Greth C, Bauer RJ, Kleinschmidt K, Bettenworth D, Böhm M, Grifka J, Grässel S.

PLoS One. 2014 Sep 5;9(9):e105858. doi: 10.1371/journal.pone.0105858. eCollection 2014.


Accelerated osteoarthritis in the temporomandibular joint of biglycan/fibromodulin double-deficient mice.

Wadhwa S, Embree MC, Kilts T, Young MF, Ameye LG.

Osteoarthritis Cartilage. 2005 Sep;13(9):817-27.


Inducible chondrocyte-specific overexpression of BMP2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage.

Blaney Davidson EN, Vitters EL, Bennink MB, van Lent PL, van Caam AP, Blom AB, van den Berg WB, van de Loo FA, van der Kraan PM.

Ann Rheum Dis. 2015 Jun;74(6):1257-64. doi: 10.1136/annrheumdis-2013-204528. Epub 2014 Jan 21.


Transcriptional profiling and pathway analysis of monosodium iodoacetate-induced experimental osteoarthritis in rats: relevance to human disease.

Barve RA, Minnerly JC, Weiss DJ, Meyer DM, Aguiar DJ, Sullivan PM, Weinrich SL, Head RD.

Osteoarthritis Cartilage. 2007 Oct;15(10):1190-8. Epub 2007 May 14.


Experimental osteoarthritis models in mice.

Lorenz J, Grässel S.

Methods Mol Biol. 2014;1194:401-19. doi: 10.1007/978-1-4939-1215-5_23.


Nociceptive Sensitizers Are Regulated in Damaged Joint Tissues, Including Articular Cartilage, When Osteoarthritic Mice Display Pain Behavior.

Driscoll C, Chanalaris A, Knights C, Ismail H, Sacitharan PK, Gentry C, Bevan S, Vincent TL.

Arthritis Rheumatol. 2016 Apr;68(4):857-67. doi: 10.1002/art.39523.

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