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Items: 1 to 20 of 95

1.

Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain.

Moon TM, Correa F, Kinch LN, Piala AT, Gardner KH, Goldsmith EJ.

J Mol Biol. 2013 Apr 26;425(8):1245-52. doi: 10.1016/j.jmb.2013.01.031. Epub 2013 Jan 30.

PMID:
23376100
2.

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR.

Biochem J. 2006 Jul 1;397(1):223-31.

3.
4.

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.

Thastrup JO, Rafiqi FH, Vitari AC, Pozo-Guisado E, Deak M, Mehellou Y, Alessi DR.

Biochem J. 2012 Jan 1;441(1):325-37. doi: 10.1042/BJ20111879.

5.

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H.

J Biol Chem. 2005 Dec 30;280(52):42685-93. Epub 2005 Oct 31.

6.

Regulation of WNK1 by an autoinhibitory domain and autophosphorylation.

Xu BE, Min X, Stippec S, Lee BH, Goldsmith EJ, Cobb MH.

J Biol Chem. 2002 Dec 13;277(50):48456-62. Epub 2002 Oct 8.

7.

Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.

Sengupta S, Tu SW, Wedin K, Earnest S, Stippec S, Luby-Phelps K, Cobb MH.

J Biol Chem. 2012 Nov 2;287(45):37868-79. doi: 10.1074/jbc.M112.398750. Epub 2012 Sep 18.

8.

WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.

Anselmo AN, Earnest S, Chen W, Juang YC, Kim SC, Zhao Y, Cobb MH.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10883-8. Epub 2006 Jul 10.

9.

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.

Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH.

J Biol Chem. 2000 Jun 2;275(22):16795-801.

10.

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT.

Sci Signal. 2014 Jul 15;7(334):re3. doi: 10.1126/scisignal.2005365. Review.

PMID:
25028718
11.

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.

Zagórska A, Pozo-Guisado E, Boudeau J, Vitari AC, Rafiqi FH, Thastrup J, Deak M, Campbell DG, Morrice NA, Prescott AR, Alessi DR.

J Cell Biol. 2007 Jan 1;176(1):89-100. Epub 2006 Dec 26.

12.

Comparison of WNK4 and WNK1 kinase and inhibiting activities.

Wang Z, Yang CL, Ellison DH.

Biochem Biophys Res Commun. 2004 May 7;317(3):939-44.

PMID:
15081430
13.

Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.

Roy A, Goodman JH, Begum G, Donnelly BF, Pittman G, Weinman EJ, Sun D, Subramanya AR.

Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F366-76. doi: 10.1152/ajprenal.00612.2014. Epub 2014 Dec 4.

14.

Domains of WNK1 kinase in the regulation of ROMK1.

Wang HR, Liu Z, Huang CL.

Am J Physiol Renal Physiol. 2008 Aug;295(2):F438-45. doi: 10.1152/ajprenal.90287.2008. Epub 2008 Jun 11.

15.
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Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.

Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15999-6004. doi: 10.1073/pnas.1419057111. Epub 2014 Oct 31.

17.

Structural insights into the recognition of substrates and activators by the OSR1 kinase.

Villa F, Goebel J, Rafiqi FH, Deak M, Thastrup J, Alessi DR, van Aalten DM.

EMBO Rep. 2007 Sep;8(9):839-45. Epub 2007 Aug 17.

18.

Properties of WNK1 and implications for other family members.

Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH.

J Biol Chem. 2005 Jul 22;280(29):26653-8. Epub 2005 May 9.

19.

A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.

Ponce-Coria J, Markadieu N, Austin TM, Flammang L, Rios K, Welling PA, Delpire E.

J Biol Chem. 2014 Jun 20;289(25):17680-8. doi: 10.1074/jbc.M113.540518. Epub 2014 May 8.

20.

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.

Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR.

J Cell Sci. 2008 Mar 1;121(Pt 5):675-84. doi: 10.1242/jcs.025312. Epub 2008 Feb 12.

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