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Synaptic vesicles position complexin to block spontaneous fusion.

Wragg RT, Snead D, Dong Y, Ramlall TF, Menon I, Bai J, Eliezer D, Dittman JS.

Neuron. 2013 Jan 23;77(2):323-34. doi: 10.1016/j.neuron.2012.11.005.


Complexin has opposite effects on two modes of synaptic vesicle fusion.

Martin JA, Hu Z, Fenz KM, Fernandez J, Dittman JS.

Curr Biol. 2011 Jan 25;21(2):97-105. doi: 10.1016/j.cub.2010.12.014. Epub 2011 Jan 6.


Complexin maintains vesicles in the primed state in C. elegans.

Hobson RJ, Liu Q, Watanabe S, Jorgensen EM.

Curr Biol. 2011 Jan 25;21(2):106-13. doi: 10.1016/j.cub.2010.12.015. Epub 2011 Jan 6.


Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous Neurotransmission.

Sabeva N, Cho RW, Vasin A, Gonzalez A, Littleton JT, Bykhovskaia M.

J Neurosci. 2017 Jan 11;37(2):383-396. doi: 10.1523/JNEUROSCI.1854-16.2016.


Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms.

Lai Y, Diao J, Cipriano DJ, Zhang Y, Pfuetzner RA, Padolina MS, Brunger AT.

Elife. 2014 Aug 13;3:e03756. doi: 10.7554/eLife.03756.


Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion.

Vasin A, Volfson D, Littleton JT, Bykhovskaia M.

Biophys J. 2016 Nov 1;111(9):1954-1964. doi: 10.1016/j.bpj.2016.09.017.


Membrane curvature sensing by the C-terminal domain of complexin.

Snead D, Wragg RT, Dittman JS, Eliezer D.

Nat Commun. 2014 Sep 17;5:4955. doi: 10.1038/ncomms5955.


C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosis.

Kaeser-Woo YJ, Yang X, Südhof TC.

J Neurosci. 2012 Feb 22;32(8):2877-85. doi: 10.1523/JNEUROSCI.3360-11.2012.


Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin.

Zhang Y, Diao J, Colbert KN, Lai Y, Pfuetzner RA, Padolina MS, Vivona S, Ressl S, Cipriano DJ, Choi UB, Shah N, Weis WI, Brunger AT.

J Biol Chem. 2015 Apr 17;290(16):10518-34. doi: 10.1074/jbc.M114.630772. Epub 2015 Feb 25.


Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutant.

Iyer J, Wahlmark CJ, Kuser-Ahnert GA, Kawasaki F.

Mol Cell Neurosci. 2013 Sep;56:244-54. doi: 10.1016/j.mcn.2013.06.002. Epub 2013 Jun 11.


Accessory alpha-helix of complexin I can displace VAMP2 locally in the complexin-SNARE quaternary complex.

Lu B, Song S, Shin YK.

J Mol Biol. 2010 Feb 26;396(3):602-9. doi: 10.1016/j.jmb.2009.12.020. Epub 2009 Dec 21. Erratum in: J Mol Biol. 2010 Apr 23;398(1):174-5.


Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.

Xue M, Craig TK, Xu J, Chao HT, Rizo J, Rosenmund C.

Nat Struct Mol Biol. 2010 May;17(5):568-75. doi: 10.1038/nsmb.1791. Epub 2010 Apr 18.


Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin.

Buhl LK, Jorquera RA, Akbergenova Y, Huntwork-Rodriguez S, Volfson D, Littleton JT.

Mol Cell Neurosci. 2013 Jan;52:161-72. doi: 10.1016/j.mcn.2012.11.009. Epub 2012 Nov 16.


Complexin controls the force transfer from SNARE complexes to membranes in fusion.

Maximov A, Tang J, Yang X, Pang ZP, Südhof TC.

Science. 2009 Jan 23;323(5913):516-21. doi: 10.1126/science.1166505.


Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes.

Yang X, Cao P, Südhof TC.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20777-82. doi: 10.1073/pnas.1321367110. Epub 2013 Dec 2.


Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release.

Malsam J, Parisotto D, Bharat TA, Scheutzow A, Krause JM, Briggs JA, Söllner TH.

EMBO J. 2012 Aug 1;31(15):3270-81. doi: 10.1038/emboj.2012.164. Epub 2012 Jun 15.


Complexin 2 modulates vesicle-associated membrane protein (VAMP) 2-regulated zymogen granule exocytosis in pancreatic acini.

Falkowski MA, Thomas DD, Groblewski GE.

J Biol Chem. 2010 Nov 12;285(46):35558-66. doi: 10.1074/jbc.M110.146597. Epub 2010 Sep 9.


Synaptic activity regulates the abundance and binding of complexin.

Wragg RT, Gouzer G, Bai J, Arianna G, Ryan TA, Dittman JS.

Biophys J. 2015 Mar 24;108(6):1318-29. doi: 10.1016/j.bpj.2014.12.057.


Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse.

Chang S, Reim K, Pedersen M, Neher E, Brose N, Taschenberger H.

J Neurosci. 2015 May 27;35(21):8272-90. doi: 10.1523/JNEUROSCI.4841-14.2015.


[The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis].

Abe T.

Tanpakushitsu Kakusan Koso. 2002 Jun;47(7):794-800. Review. Japanese. No abstract available.


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