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Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice.

Weng S, Sprague JE, Oh J, Riek AE, Chin K, Garcia M, Bernal-Mizrachi C.

PLoS One. 2013;8(1):e54625. doi: 10.1371/journal.pone.0054625. Epub 2013 Jan 22.


Macrophage paraoxonase 2 regulates calcium homeostasis and cell survival under endoplasmic reticulum stress conditions and is sufficient to prevent the development of aggravated atherosclerosis in paraoxonase 2 deficiency/apoE-/- mice on a Western diet.

Devarajan A, Grijalva VR, Bourquard N, Meriwether D 3rd, Imaizumi S, Shin BC, Devaskar SU, Reddy ST.

Mol Genet Metab. 2012 Nov;107(3):416-27. doi: 10.1016/j.ymgme.2012.06.020. Epub 2012 Jul 14.


Deletion of JNK2 prevents vitamin-D-deficiency-induced hypertension and atherosclerosis in mice.

Oh J, Riek AE, Zhang RM, Williams SAS, Darwech I, Bernal-Mizrachi C.

J Steroid Biochem Mol Biol. 2017 Sep 23. pii: S0960-0760(17)30262-5. doi: 10.1016/j.jsbmb.2017.09.014. [Epub ahead of print]


Vitamin D suppression of endoplasmic reticulum stress promotes an antiatherogenic monocyte/macrophage phenotype in type 2 diabetic patients.

Riek AE, Oh J, Sprague JE, Timpson A, de las Fuentes L, Bernal-Mizrachi L, Schechtman KB, Bernal-Mizrachi C.

J Biol Chem. 2012 Nov 9;287(46):38482-94. doi: 10.1074/jbc.M112.386912. Epub 2012 Sep 24.


Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice.

Hasan ST, Zingg JM, Kwan P, Noble T, Smith D, Meydani M.

Atherosclerosis. 2014 Jan;232(1):40-51. doi: 10.1016/j.atherosclerosis.2013.10.016. Epub 2013 Oct 31.


A deficiency of Herp, an endoplasmic reticulum stress protein, suppresses atherosclerosis in ApoE knockout mice by attenuating inflammatory responses.

Shinozaki S, Chiba T, Kokame K, Miyata T, Kaneko E, Shimokado K.

PLoS One. 2013 Oct 28;8(10):e75249. doi: 10.1371/journal.pone.0075249. eCollection 2013.


Effects of high dietary fat and cholesterol on expression of PPAR alpha, LXR alpha, and their responsive genes in the liver of apoE and LDLR double deficient mice.

Zou Y, Du H, Yin M, Zhang L, Mao L, Xiao N, Ren G, Zhang C, Pan J.

Mol Cell Biochem. 2009 Mar;323(1-2):195-205. doi: 10.1007/s11010-008-9982-3. Epub 2008 Dec 10.


Endothelin-1 overexpression exacerbates atherosclerosis and induces aortic aneurysms in apolipoprotein E knockout mice.

Li MW, Mian MO, Barhoumi T, Rehman A, Mann K, Paradis P, Schiffrin EL.

Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2306-15. doi: 10.1161/ATVBAHA.113.302028. Epub 2013 Jul 25.


Vitamin D receptor deficiency and low vitamin D diet stimulate aortic calcification and osteogenic key factor expression in mice.

Schmidt N, Brandsch C, Kühne H, Thiele A, Hirche F, Stangl GI.

PLoS One. 2012;7(4):e35316. doi: 10.1371/journal.pone.0035316. Epub 2012 Apr 20.


Endoplasmic reticulum stress and glycogen synthase kinase-3β activation in apolipoprotein E-deficient mouse models of accelerated atherosclerosis.

McAlpine CS, Bowes AJ, Khan MI, Shi Y, Werstuck GH.

Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):82-91. doi: 10.1161/ATVBAHA.111.237941. Epub 2011 Oct 13.


Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor knockout and wild-type mice.

Schmidt N, Brandsch C, Schutkowski A, Hirche F, Stangl GI.

J Nutr. 2014 May;144(5):638-46. doi: 10.3945/jn.113.189118. Epub 2014 Mar 19.


Glycogen synthase kinase 3α deficiency attenuates atherosclerosis and hepatic steatosis in high fat diet-fed low density lipoprotein receptor-deficient mice.

Banko NS, McAlpine CS, Venegas-Pino DE, Raja P, Shi Y, Khan MI, Werstuck GH.

Am J Pathol. 2014 Dec;184(12):3394-404. doi: 10.1016/j.ajpath.2014.07.028. Epub 2014 Oct 16.


1,25(OH)2 vitamin D suppresses macrophage migration and reverses atherogenic cholesterol metabolism in type 2 diabetic patients.

Riek AE, Oh J, Bernal-Mizrachi C.

J Steroid Biochem Mol Biol. 2013 Jul;136:309-12. doi: 10.1016/j.jsbmb.2012.12.019. Epub 2013 Jan 17. Review.


Macrophage beta3 integrin suppresses hyperlipidemia-induced inflammation by modulating TNFalpha expression.

Schneider JG, Zhu Y, Coleman T, Semenkovich CF.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2699-706. Epub 2007 Oct 19. Erratum in: Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):e12.


Blockade of endothelin receptors markedly reduces atherosclerosis in LDL receptor deficient mice: role of endothelin in macrophage foam cell formation.

Babaei S, Picard P, Ravandi A, Monge JC, Lee TC, Cernacek P, Stewart DJ.

Cardiovasc Res. 2000 Oct;48(1):158-67.


Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice.

Hu L, Boesten LS, May P, Herz J, Bovenschen N, Huisman MV, Berbée JF, Havekes LM, van Vlijmen BJ, Tamsma JT.

Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2710-5. Epub 2006 Oct 12.


Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E.

Tangirala RK, Praticó D, FitzGerald GA, Chun S, Tsukamoto K, Maugeais C, Usher DC, Puré E, Rader DJ.

J Biol Chem. 2001 Jan 5;276(1):261-6.


Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice.

Danzaki K, Matsui Y, Ikesue M, Ohta D, Ito K, Kanayama M, Kurotaki D, Morimoto J, Iwakura Y, Yagita H, Tsutsui H, Uede T.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):273-80. doi: 10.1161/ATVBAHA.111.229997. Epub 2011 Nov 23.


Renin-angiotensin system activation accelerates atherosclerosis in experimental renal failure by promoting endoplasmic reticulum stress-related inflammation.

Yang J, Zhang X, Yu X, Tang W, Gan H.

Int J Mol Med. 2017 Mar;39(3):613-621. doi: 10.3892/ijmm.2017.2856. Epub 2017 Jan 12.

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