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Items: 1 to 20 of 70

1.

Extensive changes in DNA methylation are associated with expression of mutant huntingtin.

Ng CW, Yildirim F, Yap YS, Dalin S, Matthews BJ, Velez PJ, Labadorf A, Housman DE, Fraenkel E.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2354-9. doi: 10.1073/pnas.1221292110. Epub 2013 Jan 22.

2.

Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.

Benn CL, Sun T, Sadri-Vakili G, McFarland KN, DiRocco DP, Yohrling GJ, Clark TW, Bouzou B, Cha JH.

J Neurosci. 2008 Oct 15;28(42):10720-33. doi: 10.1523/JNEUROSCI.2126-08.2008.

3.
4.

The long and the short of aberrant ciliogenesis in Huntington disease.

Liu JP, Zeitlin SO.

J Clin Invest. 2011 Nov;121(11):4237-41. doi: 10.1172/JCI60243. Epub 2011 Oct 10.

5.

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

Wang H, Lim PJ, Karbowski M, Monteiro MJ.

Hum Mol Genet. 2009 Feb 15;18(4):737-52. doi: 10.1093/hmg/ddn404. Epub 2008 Nov 27.

6.

CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.

Apostol BL, Simmons DA, Zuccato C, Illes K, Pallos J, Casale M, Conforti P, Ramos C, Roarke M, Kathuria S, Cattaneo E, Marsh JL, Thompson LM.

Mol Cell Neurosci. 2008 Sep;39(1):8-20. doi: 10.1016/j.mcn.2008.04.007. Epub 2008 Apr 24.

PMID:
18602275
7.

Selective degeneration in YAC mouse models of Huntington disease.

Van Raamsdonk JM, Warby SC, Hayden MR.

Brain Res Bull. 2007 Apr 30;72(2-3):124-31. Epub 2006 Nov 16. Review.

PMID:
17352936
8.

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.

Zhang H, Li Q, Graham RK, Slow E, Hayden MR, Bezprozvanny I.

Neurobiol Dis. 2008 Jul;31(1):80-8. doi: 10.1016/j.nbd.2008.03.010. Epub 2008 Apr 16.

11.

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.

Thomas EA, Coppola G, Tang B, Kuhn A, Kim S, Geschwind DH, Brown TB, Luthi-Carter R, Ehrlich ME.

Hum Mol Genet. 2011 Mar 15;20(6):1049-60. doi: 10.1093/hmg/ddq548. Epub 2010 Dec 20.

12.

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.

Chan EY, Luthi-Carter R, Strand A, Solano SM, Hanson SA, DeJohn MM, Kooperberg C, Chase KO, DiFiglia M, Young AB, Leavitt BR, Cha JH, Aronin N, Hayden MR, Olson JM.

Hum Mol Genet. 2002 Aug 15;11(17):1939-51.

PMID:
12165556
13.

Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1.

Riva L, Koeva M, Yildirim F, Pirhaji L, Dinesh D, Mazor T, Duennwald ML, Fraenkel E.

J Huntingtons Dis. 2012;1(1):33-45.

14.

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Murphy Z, Slow EJ, Leavitt BR, Hayden MR.

Hum Mol Genet. 2005 Dec 15;14(24):3823-35. Epub 2005 Nov 8.

PMID:
16278236
15.

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.

Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE.

J Biol Chem. 2003 Oct 17;278(42):41452-61. Epub 2003 Jul 29.

16.

ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line.

Liang Y, Jiang H, Ratovitski T, Jie C, Nakamura M, Hirschhorn RR, Wang X, Smith WW, Hai T, Poirier MA, Ross CA.

Brain Res. 2009 Aug 25;1286:221-9. doi: 10.1016/j.brainres.2009.06.049. Epub 2009 Jun 24.

17.

Changes in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin.

Lajoie P, Snapp EL.

J Cell Sci. 2011 Oct 1;124(Pt 19):3332-43. doi: 10.1242/jcs.087510. Epub 2011 Sep 6. Erratum in: J Cell Sci. 2012 Feb 1;125(Pt 3):789.

18.

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression.

Pouladi MA, Xie Y, Skotte NH, Ehrnhoefer DE, Graham RK, Kim JE, Bissada N, Yang XW, Paganetti P, Friedlander RM, Leavitt BR, Hayden MR.

Hum Mol Genet. 2010 Apr 15;19(8):1528-38. doi: 10.1093/hmg/ddq026. Epub 2010 Jan 22.

19.

Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

Giorgini F, Möller T, Kwan W, Zwilling D, Wacker JL, Hong S, Tsai LC, Cheah CS, Schwarcz R, Guidetti P, Muchowski PJ.

J Biol Chem. 2008 Mar 21;283(12):7390-400. Epub 2007 Dec 13.

20.

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR.

J Neurosci. 2002 Sep 15;22(18):7862-72.

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