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Accelerated high-yield generation of limb-innervating motor neurons from human stem cells.

Amoroso MW, Croft GF, Williams DJ, O'Keeffe S, Carrasco MA, Davis AR, Roybon L, Oakley DH, Maniatis T, Henderson CE, Wichterle H.

J Neurosci. 2013 Jan 9;33(2):574-86. doi: 10.1523/JNEUROSCI.0906-12.2013.


Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells.

Adams KL, Rousso DL, Umbach JA, Novitch BG.

Nat Commun. 2015 Apr 14;6:6778. doi: 10.1038/ncomms7778.


Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons.

Soundararajan P, Miles GB, Rubin LL, Brownstone RM, Rafuse VF.

J Neurosci. 2006 Mar 22;26(12):3256-68.


Detailed expression pattern of Foxp1 and its possible roles in neurons of the spinal cord during embryogenesis.

Morikawa Y, Komori T, Hisaoka T, Senba E.

Dev Neurosci. 2009;31(6):511-22. doi: 10.1159/000243715.


A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity.

Thaler JP, Koo SJ, Kania A, Lettieri K, Andrews S, Cox C, Jessell TM, Pfaff SL.

Neuron. 2004 Feb 5;41(3):337-50.


Regulation of motor neuron subtype identity by repressor activity of Mnx class homeodomain proteins.

William CM, Tanabe Y, Jessell TM.

Development. 2003 Apr;130(8):1523-36.


Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs.

Lee S, Cuvillier JM, Lee B, Shen R, Lee JW, Lee SK.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3383-8. doi: 10.1073/pnas.1114515109.


Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution.

Kim N, Park C, Jeong Y, Song MR.

PLoS Genet. 2015 Oct 8;11(10):e1005560. doi: 10.1371/journal.pgen.1005560.


Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity.

Arber S, Han B, Mendelsohn M, Smith M, Jessell TM, Sockanathan S.

Neuron. 1999 Aug;23(4):659-74.


Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling.

Palmesino E, Rousso DL, Kao TJ, Klar A, Laufer E, Uemura O, Okamoto H, Novitch BG, Kania A.

PLoS Biol. 2010 Aug 10;8(8):e1000446. doi: 10.1371/journal.pbio.1000446.


Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.

Dasen JS, De Camilli A, Wang B, Tucker PW, Jessell TM.

Cell. 2008 Jul 25;134(2):304-16. doi: 10.1016/j.cell.2008.06.019.


miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3.

Thiebes KP, Nam H, Cambronne XA, Shen R, Glasgow SM, Cho HH, Kwon JS, Goodman RH, Lee JW, Lee S, Lee SK.

Nat Commun. 2015 Jul 27;6:7718. doi: 10.1038/ncomms8718. Erratum in: Nat Commun. 2015;6:8227.


Global control of motor neuron topography mediated by the repressive actions of a single hox gene.

Jung H, Lacombe J, Mazzoni EO, Liem KF Jr, Grinstein J, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS.

Neuron. 2010 Sep 9;67(5):781-96. doi: 10.1016/j.neuron.2010.08.008.


Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb.

Luria V, Krawchuk D, Jessell TM, Laufer E, Kania A.

Neuron. 2008 Dec 26;60(6):1039-53. doi: 10.1016/j.neuron.2008.11.011.


Isl1 is required for multiple aspects of motor neuron development.

Liang X, Song MR, Xu Z, Lanuza GM, Liu Y, Zhuang T, Chen Y, Pfaff SL, Evans SM, Sun Y.

Mol Cell Neurosci. 2011 Jul;47(3):215-22. doi: 10.1016/j.mcn.2011.04.007.


LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons.

Sharma K, Sheng HZ, Lettieri K, Li H, Karavanov A, Potter S, Westphal H, Pfaff SL.

Cell. 1998 Dec 11;95(6):817-28.

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