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A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells.

Xie L, Gazin C, Park SM, Zhu LJ, Debily MA, Kittler EL, Zapp ML, Lapointe D, Gobeil S, Virbasius CM, Green MR.

PLoS Genet. 2012;8(12):e1003151. doi: 10.1371/journal.pgen.1003151. Epub 2012 Dec 20.


Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.

Demidova AR, Aau MY, Zhuang L, Yu Q.

J Biol Chem. 2009 Feb 13;284(7):4132-9. doi: 10.1074/jbc.M808118200. Epub 2008 Dec 7.


ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.

Pabla N, Huang S, Mi QS, Daniel R, Dong Z.

J Biol Chem. 2008 Mar 7;283(10):6572-83. Epub 2007 Dec 27. Erratum in: J Biol Chem. 2008 May 30;283(22):15512.


The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function.

Lo PK, Lee JS, Sukumar S.

Cell Signal. 2012 Jan;24(1):316-24. doi: 10.1016/j.cellsig.2011.09.017. Epub 2011 Sep 22.


Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells.

Knobel PA, Kotov IN, Felley-Bosco E, Stahel RA, Marti TM.

Neoplasia. 2011 Oct;13(10):961-70.


p53-dependent down-regulation of telomerase is mediated by p21waf1.

Shats I, Milyavsky M, Tang X, Stambolsky P, Erez N, Brosh R, Kogan I, Braunstein I, Tzukerman M, Ginsberg D, Rotter V.

J Biol Chem. 2004 Dec 3;279(49):50976-85. Epub 2004 Sep 15.


S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.

Wong VC, Cash HL, Morse JL, Lu S, Zhitkovich A.

Cell Cycle. 2012 Jul 1;11(13):2526-37. doi: 10.4161/cc.20905. Epub 2012 Jul 1.


ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.

Sirbu BM, Lachmayer SJ, W├╝lfing V, Marten LM, Clarkson KE, Lee LW, Gheorghiu L, Zou L, Powell SN, Dahm-Daphi J, Willers H.

PLoS One. 2011;6(8):e23053. doi: 10.1371/journal.pone.0023053. Epub 2011 Aug 12.


The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA.

Gewandter JS, Bambara RA, O'Reilly MA.

Cell Cycle. 2011 Aug 1;10(15):2561-7. Epub 2011 Aug 1.


Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

Reaper PM, Griffiths MR, Long JM, Charrier JD, Maccormick S, Charlton PA, Golec JM, Pollard JR.

Nat Chem Biol. 2011 Apr 13;7(7):428-30. doi: 10.1038/nchembio.573.


Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation.

Blackford AN, Patel RN, Forrester NA, Theil K, Groitl P, Stewart GS, Taylor AM, Morgan IM, Dobner T, Grand RJ, Turnell AS.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12251-6. doi: 10.1073/pnas.0914605107. Epub 2010 Jun 21.


Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis.

Teoh N, Pyakurel P, Dan YY, Swisshelm K, Hou J, Mitchell C, Fausto N, Gu Y, Farrell G.

Gastroenterology. 2010 Mar;138(3):1155-65.e1-2. doi: 10.1053/j.gastro.2009.11.008. Epub 2009 Nov 14.


hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage.

Moumen A, Masterson P, O'Connor MJ, Jackson SP.

Cell. 2005 Dec 16;123(6):1065-78.


Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation.

Kulkarni A, Das KC.

Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L998-L1006. doi: 10.1152/ajplung.00004.2008. Epub 2008 Mar 14.


Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.

Das KC, Dashnamoorthy R.

Am J Physiol Lung Cell Mol Physiol. 2004 Jan;286(1):L87-97. Epub 2003 Sep 5.


UVB-Induced p21 degradation promotes apoptosis of human keratinocytes.

Lei X, Liu B, Han W, Ming M, He YY.

Photochem Photobiol Sci. 2010 Dec;9(12):1640-8. doi: 10.1039/c0pp00244e. Epub 2010 Oct 8.


DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair.

Serrano MA, Li Z, Dangeti M, Musich PR, Patrick S, Roginskaya M, Cartwright B, Zou Y.

Oncogene. 2013 May 9;32(19):2452-62. doi: 10.1038/onc.2012.257. Epub 2012 Jul 16.


Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells.

Rankin AM, Sarkar S, Faller DV.

J Cell Physiol. 2012 Jun;227(6):2586-94. doi: 10.1002/jcp.22997.

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