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Items: 1 to 20 of 117

1.

A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.

Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe J.

Circulation. 2013 Jan 29;127(4):486-99. doi: 10.1161/CIRCULATIONAHA.112.116988. Epub 2012 Dec 14.

2.

p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.

Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J.

Circ Res. 2012 Feb 17;110(4):536-50. doi: 10.1161/CIRCRESAHA.111.254730. Epub 2012 Jan 19.

3.

Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells.

Woo CH, Shishido T, McClain C, Lim JH, Li JD, Yang J, Yan C, Abe J.

Circ Res. 2008 Mar 14;102(5):538-45. doi: 10.1161/CIRCRESAHA.107.156877. Epub 2008 Jan 24.

4.

Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.

Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J.

J Clin Invest. 2015 Mar 2;125(3):1299-310. doi: 10.1172/JCI76453. Epub 2015 Feb 17.

5.

De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis.

Heo KS, Chang E, Le NT, Cushman H, Yeh ET, Fujiwara K, Abe J.

Circ Res. 2013 Mar 15;112(6):911-23. doi: 10.1161/CIRCRESAHA.111.300179. Epub 2013 Feb 4.

6.

Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents.

Le NT, Takei Y, Izawa-Ishizawa Y, Heo KS, Lee H, Smrcka AV, Miller BL, Ko KA, Ture S, Morrell C, Fujiwara K, Akaike M, Abe J.

J Immunol. 2014 Oct 1;193(7):3803-15. doi: 10.4049/jimmunol.1400571. Epub 2014 Sep 3.

7.

Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation.

Kim M, Kim S, Lim JH, Lee C, Choi HC, Woo CH.

J Biol Chem. 2012 Nov 23;287(48):40722-31. doi: 10.1074/jbc.M112.381509. Epub 2012 Oct 5.

8.

Ionizing Radiation Induces Endothelial Inflammation and Apoptosis via p90RSK-Mediated ERK5 S496 Phosphorylation.

Vu HT, Kotla S, Ko KA, Fujii Y, Tao Y, Medina J, Thomas T, Hada M, Sood AK, Singh PK, Milgrom SA, Krishnan S, Fujiwara K, Le NT, Abe JI.

Front Cardiovasc Med. 2018 Mar 14;5:23. doi: 10.3389/fcvm.2018.00023. eCollection 2018.

9.

PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.

Nigro P, Abe J, Woo CH, Satoh K, McClain C, O'Dell MR, Lee H, Lim JH, Li JD, Heo KS, Fujiwara K, Berk BC.

Blood. 2010 Sep 16;116(11):1971-9. doi: 10.1182/blood-2010-02-269134. Epub 2010 Jun 10.

10.

Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice.

Lu J, Xiang G, Liu M, Mei W, Xiang L, Dong J.

Atherosclerosis. 2015 Dec;243(2):438-48. doi: 10.1016/j.atherosclerosis.2015.10.020. Epub 2015 Oct 19.

PMID:
26520898
11.

Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction.

Shishido T, Woo CH, Ding B, McClain C, Molina CA, Yan C, Yang J, Abe J.

Circ Res. 2008 Jun 6;102(11):1416-25. doi: 10.1161/CIRCRESAHA.107.168138. Epub 2008 May 8.

12.

Erk5 inhibits endothelial migration via KLF2-dependent down-regulation of PAK1.

Komaravolu RK, Adam C, Moonen JR, Harmsen MC, Goebeler M, Schmidt M.

Cardiovasc Res. 2015 Jan 1;105(1):86-95. doi: 10.1093/cvr/cvu236. Epub 2014 Nov 10.

PMID:
25388666
13.

Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.

Itoh S, Ding B, Shishido T, Lerner-Marmarosh N, Wang N, Maekawa N, Berk BC, Takeishi Y, Yan C, Blaxall BC, Abe J.

Circulation. 2006 Apr 11;113(14):1787-98. Epub 2006 Apr 3.

14.

BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis.

Singh KK, Shukla PC, Quan A, Al-Omran M, Lovren F, Pan Y, Brezden-Masley C, Ingram AJ, Stanford WL, Teoh H, Verma S.

J Thorac Cardiovasc Surg. 2013 Oct;146(4):949-960.e4. doi: 10.1016/j.jtcvs.2012.12.064. Epub 2013 Feb 14.

15.

Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPK-p90RSK, and Rho-kinase pathway.

Kobayashi N, Hara K, Tojo A, Onozato ML, Honda T, Yoshida K, Mita S, Nakano S, Tsubokou Y, Matsuoka H.

Hypertension. 2005 Apr;45(4):538-44. Epub 2005 Feb 14.

16.

Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.

Wang XQ, Nigro P, World C, Fujiwara K, Yan C, Berk BC.

Circ Res. 2012 Feb 17;110(4):560-8. doi: 10.1161/CIRCRESAHA.111.256362. Epub 2012 Jan 19.

17.

Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic rats.

Wu Y, Feng B, Chen S, Zuo Y, Chakrabarti S.

Can J Physiol Pharmacol. 2010 Jun;88(6):607-15. doi: 10.1139/Y10-033.

18.

Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity.

Lu Z, Abe J, Taunton J, Lu Y, Shishido T, McClain C, Yan C, Xu SP, Spangenberg TM, Xu H.

Circ Res. 2008 Aug 1;103(3):269-78. doi: 10.1161/CIRCRESAHA.107.166678. Epub 2008 Jul 3. Erratum in: Circ Res.2008 Sep 12;103(6):e80.

19.

Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis.

Lovren F, Pan Y, Shukla PC, Quan A, Teoh H, Szmitko PE, Peterson MD, Gupta M, Al-Omran M, Verma S.

Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1440-9. doi: 10.1152/ajpendo.90780.2008. Epub 2009 Apr 7.

20.

Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis.

Pi X, Yan C, Berk BC.

Circ Res. 2004 Feb 20;94(3):362-9. Epub 2003 Dec 11.

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