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Items: 1 to 20 of 91

1.

Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules.

Guo Y, Partch CL, Key J, Card PB, Pashkov V, Patel A, Bruick RK, Wurdak H, Gardner KH.

ACS Chem Biol. 2013 Mar 15;8(3):626-35. doi: 10.1021/cb300604u. Epub 2012 Dec 26.

2.

Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization.

Guo Y, Scheuermann TH, Partch CL, Tomchick DR, Gardner KH.

J Biol Chem. 2015 Mar 20;290(12):7707-21. doi: 10.1074/jbc.M114.632786. Epub 2015 Jan 27.

3.

Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B.

Partch CL, Gardner KH.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7739-44. doi: 10.1073/pnas.1101357108. Epub 2011 Apr 21.

4.

Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction.

Cardoso R, Love R, Nilsson CL, Bergqvist S, Nowlin D, Yan J, Liu KK, Zhu J, Chen P, Deng YL, Dyson HJ, Greig MJ, Brooun A.

Protein Sci. 2012 Dec;21(12):1885-96. doi: 10.1002/pro.2172. Epub 2012 Nov 9.

5.

NcoA2-Dependent Inhibition of HIF-1α Activation Is Regulated via AhR.

Tsai CH, Li CH, Liao PL, Cheng YW, Lin CH, Huang SH, Kang JJ.

Toxicol Sci. 2015 Dec;148(2):517-30. doi: 10.1093/toxsci/kfv199. Epub 2015 Sep 8.

PMID:
26350169
6.

Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor.

Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK.

J Med Chem. 2013 Feb 28;56(4):1739-47. doi: 10.1021/jm301847z. Epub 2013 Feb 18.

8.

Targeting the PAS-A domain of HIF-1alpha for development of small molecule inhibitors of HIF-1.

Park EJ, Kong D, Fisher R, Cardellina J, Shoemaker RH, Melillo G.

Cell Cycle. 2006 Aug;5(16):1847-53. Epub 2006 Aug 15.

PMID:
16861921
9.

A cell-penetrating peptide suppresses the hypoxia inducible factor-1 function by binding to the helix-loop-helix domain of the aryl hydrocarbon receptor nuclear translocator.

Wang Y, Thompson JD, Chan WK.

Chem Biol Interact. 2013 Apr 25;203(2):401-11. doi: 10.1016/j.cbi.2013.02.003. Epub 2013 Feb 27.

11.

Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT).

Partch CL, Card PB, Amezcua CA, Gardner KH.

J Biol Chem. 2009 May 29;284(22):15184-92. doi: 10.1074/jbc.M808479200. Epub 2009 Mar 26.

12.

Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor.

Kallio PJ, Pongratz I, Gradin K, McGuire J, Poellinger L.

Proc Natl Acad Sci U S A. 1997 May 27;94(11):5667-72.

13.

Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.

Scheuermann TH, Tomchick DR, Machius M, Guo Y, Bruick RK, Gardner KH.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):450-5. doi: 10.1073/pnas.0808092106. Epub 2009 Jan 7.

14.

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT.

Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, Cohen B.

EMBO J. 1998 Sep 1;17(17):5085-94.

16.

Inhibition of TACC3 by a small molecule inhibitor in breast cancer.

Campo L, Breuer EK.

Biochem Biophys Res Commun. 2018 Apr 15;498(4):1085-1092. doi: 10.1016/j.bbrc.2018.03.125. Epub 2018 Mar 19.

PMID:
29555478
17.
18.

The Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT/HIF-1β) is influenced by hypoxia and hypoxia-mimetics.

Wolff M, Jelkmann W, Dunst J, Depping R.

Cell Physiol Biochem. 2013;32(4):849-58. doi: 10.1159/000354487. Epub 2013 Sep 20.

19.

Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway.

Ohoka N, Nagai K, Hattori T, Okuhira K, Shibata N, Cho N, Naito M.

Cell Death Dis. 2014 Nov 6;5:e1513. doi: 10.1038/cddis.2014.471.

20.

Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators.

Chapman-Smith A, Lutwyche JK, Whitelaw ML.

J Biol Chem. 2004 Feb 13;279(7):5353-62. Epub 2003 Nov 24.

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