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C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex.

Mauxion F, Prève B, Séraphin B.

RNA Biol. 2013 Feb;10(2):267-76. doi: 10.4161/rna.23065. Epub 2012 Dec 11.


NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain.

Bawankar P, Loh B, Wohlbold L, Schmidt S, Izaurralde E.

RNA Biol. 2013 Feb;10(2):228-44. doi: 10.4161/rna.23018. Epub 2013 Jan 9.


The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.

Maryati M, Airhihen B, Winkler GS.

Biochem J. 2015 Jul 1;469(1):169-76. doi: 10.1042/BJ20150304. Epub 2015 May 6.


Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction.

Basquin J, Roudko VV, Rode M, Basquin C, Séraphin B, Conti E.

Mol Cell. 2012 Oct 26;48(2):207-18. doi: 10.1016/j.molcel.2012.08.014. Epub 2012 Sep 6.


The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability.

Ito K, Takahashi A, Morita M, Suzuki T, Yamamoto T.

Protein Cell. 2011 Sep;2(9):755-63. doi: 10.1007/s13238-011-1092-4. Epub 2011 Oct 6.


CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells.

Piao X, Zhang X, Wu L, Belasco JG.

Mol Cell Biol. 2010 Mar;30(6):1486-94. doi: 10.1128/MCB.01481-09. Epub 2010 Jan 11.


Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression.

Bhandari D, Raisch T, Weichenrieder O, Jonas S, Izaurralde E.

Genes Dev. 2014 Apr 15;28(8):888-901. doi: 10.1101/gad.237289.113.


mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes.

Behm-Ansmant I, Rehwinkel J, Doerks T, Stark A, Bork P, Izaurralde E.

Genes Dev. 2006 Jul 15;20(14):1885-98. Epub 2006 Jun 30.


Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAs.

Färber V, Erben E, Sharma S, Stoecklin G, Clayton C.

Nucleic Acids Res. 2013 Jan;41(2):1211-22. doi: 10.1093/nar/gks1133. Epub 2012 Dec 4.


Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes.

Cui Y, Ramnarain DB, Chiang YC, Ding LH, McMahon JS, Denis CL.

Mol Genet Genomics. 2008 Apr;279(4):323-37. doi: 10.1007/s00438-007-0314-1. Epub 2008 Jan 23.


Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.

Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT.

Nucleic Acids Res. 2000 Feb 1;28(3):809-17.


The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.

Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O.

Nucleic Acids Res. 2012 Nov;40(21):11058-72. doi: 10.1093/nar/gks883. Epub 2012 Sep 12.


The Not3/5 subunit of the Ccr4-Not complex: a central regulator of gene expression that integrates signals between the cytoplasm and the nucleus in eukaryotic cells.

Collart MA, Panasenko OO, Nikolaev SI.

Cell Signal. 2013 Apr;25(4):743-51. doi: 10.1016/j.cellsig.2012.12.018. Epub 2012 Dec 29. Review.


Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression.

Mathys H, Basquin J, Ozgur S, Czarnocki-Cieciura M, Bonneau F, Aartse A, Dziembowski A, Nowotny M, Conti E, Filipowicz W.

Mol Cell. 2014 Jun 5;54(5):751-65. doi: 10.1016/j.molcel.2014.03.036. Epub 2014 Apr 24.


Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation.

Ezzeddine N, Chang TC, Zhu W, Yamashita A, Chen CY, Zhong Z, Yamashita Y, Zheng D, Shyu AB.

Mol Cell Biol. 2007 Nov;27(22):7791-801. Epub 2007 Sep 4.


miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.

Fabian MR, Cieplak MK, Frank F, Morita M, Green J, Srikumar T, Nagar B, Yamamoto T, Raught B, Duchaine TF, Sonenberg N.

Nat Struct Mol Biol. 2011 Oct 7;18(11):1211-7. doi: 10.1038/nsmb.2149. Erratum in: Nat Struct Mol Biol. 2012 Mar;19(3):364.


CAF1 plays an important role in mRNA deadenylation separate from its contact to CCR4.

Ohn T, Chiang YC, Lee DJ, Yao G, Zhang C, Denis CL.

Nucleic Acids Res. 2007;35(9):3002-15. Epub 2007 Apr 16.


The structural basis for deadenylation by the CCR4-NOT complex.

Bartlam M, Yamamoto T.

Protein Cell. 2010 May;1(5):443-52. doi: 10.1007/s13238-010-0060-8. Epub 2010 Jun 4. Review.

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