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Items: 1 to 20 of 199

1.

Protein kinase C-β contributes to impaired endothelial insulin signaling in humans with diabetes mellitus.

Tabit CE, Shenouda SM, Holbrook M, Fetterman JL, Kiani S, Frame AA, Kluge MA, Held A, Dohadwala MM, Gokce N, Farb MG, Rosenzweig J, Ruderman N, Vita JA, Hamburg NM.

Circulation. 2013 Jan 1;127(1):86-95. doi: 10.1161/CIRCULATIONAHA.112.127514. Epub 2012 Nov 30.

2.

Endothelial Dysfunction in Human Diabetes Is Mediated by Wnt5a-JNK Signaling.

Bretón-Romero R, Feng B, Holbrook M, Farb MG, Fetterman JL, Linder EA, Berk BD, Masaki N, Weisbrod RM, Inagaki E, Gokce N, Fuster JJ, Walsh K, Hamburg NM.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):561-9. doi: 10.1161/ATVBAHA.115.306578. Epub 2016 Jan 21.

3.

Apolipoprotein CIII links hyperlipidemia with vascular endothelial cell dysfunction.

Kawakami A, Osaka M, Tani M, Azuma H, Sacks FM, Shimokado K, Yoshida M.

Circulation. 2008 Aug 12;118(7):731-42. doi: 10.1161/CIRCULATIONAHA.108.784785. Epub 2008 Jul 28. Retraction in: Circulation. 2012 Feb 14;125(6):e362.

4.

Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling.

Fetterman JL, Holbrook M, Flint N, Feng B, Bretón-Romero R, Linder EA, Berk BD, Duess MA, Farb MG, Gokce N, Shirihai OS, Hamburg NM, Vita JA.

Atherosclerosis. 2016 Apr;247:207-17. doi: 10.1016/j.atherosclerosis.2016.01.043. Epub 2016 Feb 13.

5.

Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.

Kuboki K, Jiang ZY, Takahara N, Ha SW, Igarashi M, Yamauchi T, Feener EP, Herbert TP, Rhodes CJ, King GL.

Circulation. 2000 Feb 15;101(6):676-81.

6.

Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice.

Lu J, Xiang G, Liu M, Mei W, Xiang L, Dong J.

Atherosclerosis. 2015 Dec;243(2):438-48. doi: 10.1016/j.atherosclerosis.2015.10.020. Epub 2015 Oct 19.

PMID:
26520898
7.

Feed-forward signaling of TNF-alpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice.

Yang J, Park Y, Zhang H, Xu X, Laine GA, Dellsperger KC, Zhang C.

Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1850-8. doi: 10.1152/ajpheart.01199.2008. Epub 2009 Apr 10.

8.

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes.

Paneni F, Costantino S, Castello L, Battista R, Capretti G, Chiandotto S, D'Amario D, Scavone G, Villano A, Rustighi A, Crea F, Pitocco D, Lanza G, Volpe M, Del Sal G, Lüscher TF, Cosentino F.

Eur Heart J. 2015 Apr 1;36(13):817-28. doi: 10.1093/eurheartj/ehu179. Epub 2014 May 5.

PMID:
24801072
9.

PPARβ activation restores the high glucose-induced impairment of insulin signalling in endothelial cells.

Quintela AM, Jiménez R, Piqueras L, Gómez-Guzmán M, Haro J, Zarzuelo MJ, Cogolludo A, Sanz MJ, Toral M, Romero M, Pérez-Vizcaíno F, Duarte J.

Br J Pharmacol. 2014 Jun;171(12):3089-102. doi: 10.1111/bph.12646.

10.

β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia.

Karimi Galougahi K, Liu CC, Garcia A, Gentile C, Fry NA, Hamilton EJ, Hawkins CL, Figtree GA.

J Am Heart Assoc. 2016 Feb 19;5(2). pii: e002824. doi: 10.1161/JAHA.115.002824.

11.

Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta.

Kim F, Tysseling KA, Rice J, Pham M, Haji L, Gallis BM, Baas AS, Paramsothy P, Giachelli CM, Corson MA, Raines EW.

Arterioscler Thromb Vasc Biol. 2005 May;25(5):989-94. Epub 2005 Feb 24.

12.

Glimepiride upregulates eNOS activity and inhibits cytokine-induced NF-kappaB activation through a phosphoinoside 3-kinase-Akt-dependent pathway.

Jojima T, Suzuki K, Hirama N, Uchida K, Hattori Y.

Diabetes Obes Metab. 2009 Feb;11(2):143-9. doi: 10.1111/j.1463-1326.2008.00923.x. Epub 2008 Jun 16.

PMID:
18564176
13.

Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity.

Mima A, Ohshiro Y, Kitada M, Matsumoto M, Geraldes P, Li C, Li Q, White GS, Cahill C, Rask-Madsen C, King GL.

Kidney Int. 2011 Apr;79(8):883-96. doi: 10.1038/ki.2010.526. Epub 2011 Jan 12.

14.

Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats.

Nemoto S, Kobayashi T, Taguchi K, Matsumoto T, Kamata K.

Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2383-94. doi: 10.1152/ajpheart.00178.2011. Epub 2011 Sep 16.

15.

Inhibitor-κB kinase attenuates Hsp90-dependent endothelial nitric oxide synthase function in vascular endothelial cells.

Natarajan M, Konopinski R, Krishnan M, Roman L, Bera A, Hongying Z, Habib SL, Mohan S.

Am J Physiol Cell Physiol. 2015 Apr 15;308(8):C673-83. doi: 10.1152/ajpcell.00367.2014. Epub 2015 Feb 4.

16.

Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase.

Soro-Paavonen A, Zhang WZ, Venardos K, Coughlan MT, Harris E, Tong DC, Brasacchio D, Paavonen K, Chin-Dusting J, Cooper ME, Kaye D, Thomas MC, Forbes JM.

J Hypertens. 2010 Apr;28(4):780-8. doi: 10.1097/HJH.0b013e328335043e.

PMID:
20186099
17.

Targeting vascular endothelial cell insulin resistance in type 2 diabetes mellitus: is protein kinase cβ the bullseye for reducing vascular risk in diabetes?

Pierce GL.

Circulation. 2013 Jan 1;127(1):16-8. doi: 10.1161/CIRCULATIONAHA.112.150813. Epub 2012 Nov 30. No abstract available.

18.

Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells.

Andreozzi F, Laratta E, Procopio C, Hribal ML, Sciacqua A, Perticone M, Miele C, Perticone F, Sesti G.

Mol Cell Biol. 2007 Mar;27(6):2372-83. Epub 2007 Jan 22.

19.

Protein kinase CbetaII-mediated phosphorylation of endothelial nitric oxide synthase threonine 495 mediates the endothelial dysfunction induced by FK506 (tacrolimus).

Chiasson VL, Quinn MA, Young KJ, Mitchell BM.

J Pharmacol Exp Ther. 2011 Jun;337(3):718-23. doi: 10.1124/jpet.110.178095. Epub 2011 Mar 7.

20.

Direct Endothelial Nitric Oxide Synthase Activation Provides Atheroprotection in Diabetes-Accelerated Atherosclerosis.

Sharma A, Sellers S, Stefanovic N, Leung C, Tan SM, Huet O, Granville DJ, Cooper ME, de Haan JB, Bernatchez P.

Diabetes. 2015 Nov;64(11):3937-50. doi: 10.2337/db15-0472. Epub 2015 Jun 26.

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