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The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1.

Yang Z, Wang X, He Y, Qi L, Yu L, Xue B, Shi H.

PLoS One. 2012;7(11):e49935. doi: 10.1371/journal.pone.0049935. Epub 2012 Nov 21.


Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet.

Ka SO, Song MY, Bae EJ, Park BH.

J Endocrinol. 2015 Feb;224(2):109-18. doi: 10.1530/JOE-14-0527. Epub 2014 Oct 27.


Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.

Bergeron R, Previs SF, Cline GW, Perret P, Russell RR 3rd, Young LH, Shulman GI.

Diabetes. 2001 May;50(5):1076-82.


Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1.

Yang Z, Kahn BB, Shi H, Xue BZ.

J Biol Chem. 2010 Jun 18;285(25):19051-9. doi: 10.1074/jbc.M110.123620. Epub 2010 Apr 26.


AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats.

Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW.

Diabetes. 2002 Oct;51(10):2886-94. Erratum in: Diabetes 2003 Jan;52(1):223-4.


Activation of insulin signaling and energy sensing network by AICAR, an AMPK activator in insulin resistant rat tissues.

Radika MK, Anuradha CV.

J Basic Clin Physiol Pharmacol. 2015 Nov;26(6):563-74. doi: 10.1515/jbcpp-2014-0122.


Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1.

Dong J, Zhang X, Zhang L, Bian HX, Xu N, Bao B, Liu J.

J Lipid Res. 2014 Mar;55(3):363-74. doi: 10.1194/jlr.M038786. Epub 2014 Jan 24.


AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle.

Drake JC, Alway SE, Hollander JM, Williamson DL.

Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1546-54. doi: 10.1152/ajpregu.00337.2010. Epub 2010 Sep 15.


Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

Jørgensen SB, Viollet B, Andreelli F, Frøsig C, Birk JB, Schjerling P, Vaulont S, Richter EA, Wojtaszewski JF.

J Biol Chem. 2004 Jan 9;279(2):1070-9. Epub 2003 Oct 21.


Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome.

Buhl ES, Jessen N, Pold R, Ledet T, Flyvbjerg A, Pedersen SB, Pedersen O, Schmitz O, Lund S.

Diabetes. 2002 Jul;51(7):2199-206.


Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue.

Hui X, Zhang M, Gu P, Li K, Gao Y, Wu D, Wang Y, Xu A.

EMBO Rep. 2017 Apr;18(4):645-657. doi: 10.15252/embr.201643184. Epub 2017 Mar 7.


5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice.

Song XM, Fiedler M, Galuska D, Ryder JW, Fernström M, Chibalin AV, Wallberg-Henriksson H, Zierath JR.

Diabetologia. 2002 Jan;45(1):56-65.


Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose transport in skeletal muscle.

Ryder JW, Long YC, Nilsson E, Mahlapuu M, Zierath JR.

J Physiol. 2005 Sep 1;567(Pt 2):379-86. Epub 2005 Jun 23.


Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise.

Liu W, Zhai X, Li H, Ji L.

J Affect Disord. 2014 Mar;156:171-7. doi: 10.1016/j.jad.2013.11.025. Epub 2013 Dec 17.


Loss of regulator of G protein signaling 5 exacerbates obesity, hepatic steatosis, inflammation and insulin resistance.

Deng W, Wang X, Xiao J, Chen K, Zhou H, Shen D, Li H, Tang Q.

PLoS One. 2012;7(1):e30256. doi: 10.1371/journal.pone.0030256. Epub 2012 Jan 17.


Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.

Sun Y, Li J, Xiao N, Wang M, Kou J, Qi L, Huang F, Liu B, Liu K.

Pharmacol Res. 2014 Nov;89:19-28. doi: 10.1016/j.phrs.2014.07.006. Epub 2014 Aug 7.


Chronic treatment with the AMP-kinase activator AICAR increases glycogen storage and fatty acid oxidation in skeletal muscles but does not reduce hyperglucagonemia and hyperglycemia in insulin deficient rats.

Vitzel KF, Bikopoulos G, Hung S, Pistor KE, Patterson JD, Curi R, Ceddia RB.

PLoS One. 2013 Apr 19;8(4):e62190. doi: 10.1371/journal.pone.0062190. Print 2013.

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