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Items: 1 to 20 of 118

1.

Rational design of potent domain antibody inhibitors of amyloid fibril assembly.

Ladiwala AR, Bhattacharya M, Perchiacca JM, Cao P, Raleigh DP, Abedini A, Schmidt AM, Varkey J, Langen R, Tessier PM.

Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):19965-70. doi: 10.1073/pnas.1208797109. Epub 2012 Nov 15. Erratum in: Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1560.

2.

Structure-based design of conformation- and sequence-specific antibodies against amyloid β.

Perchiacca JM, Ladiwala AR, Bhattacharya M, Tessier PM.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):84-9. doi: 10.1073/pnas.1111232108. Epub 2011 Dec 14.

3.

Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid Polypeptide.

Lee CC, Julian MC, Tiller KE, Meng F, DuConge SE, Akter R, Raleigh DP, Tessier PM.

J Biol Chem. 2016 Feb 5;291(6):2858-73. doi: 10.1074/jbc.M115.682336. Epub 2015 Nov 24.

4.
5.

Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins.

Sormanni P, Aprile FA, Vendruscolo M.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9902-7. doi: 10.1073/pnas.1422401112. Epub 2015 Jul 27.

6.

Designed hairpin peptides interfere with amyloidogenesis pathways: fibril formation and cytotoxicity inhibition, interception of the preamyloid state.

Huggins KN, Bisaglia M, Bubacco L, Tatarek-Nossol M, Kapurniotu A, Andersen NH.

Biochemistry. 2011 Sep 27;50(38):8202-12. doi: 10.1021/bi200760h. Epub 2011 Aug 30.

7.

Molecular characterization of the hetero-assembly of β-amyloid peptide with islet amyloid polypeptide.

Yan LM, Velkova A, Kapurniotu A.

Curr Pharm Des. 2014;20(8):1182-91.

PMID:
23713771
8.

General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers.

Wang H, Raleigh DP.

PLoS One. 2014 Sep 26;9(9):e104023. doi: 10.1371/journal.pone.0104023. eCollection 2014.

9.

N-terminal domain of myelin basic protein inhibits amyloid beta-protein fibril assembly.

Liao MC, Hoos MD, Aucoin D, Ahmed M, Davis J, Smith SO, Van Nostrand WE.

J Biol Chem. 2010 Nov 12;285(46):35590-8. doi: 10.1074/jbc.M110.169599. Epub 2010 Aug 31.

10.

Defining the molecular basis of amyloid inhibitors: human islet amyloid polypeptide-insulin interactions.

Susa AC, Wu C, Bernstein SL, Dupuis NF, Wang H, Raleigh DP, Shea JE, Bowers MT.

J Am Chem Soc. 2014 Sep 17;136(37):12912-9. doi: 10.1021/ja504031d. Epub 2014 Sep 4.

11.

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.

Conway KA, Harper JD, Lansbury PT Jr.

Biochemistry. 2000 Mar 14;39(10):2552-63.

PMID:
10704204
12.

A β-hairpin-binding protein for three different disease-related amyloidogenic proteins.

Shaykhalishahi H, Mirecka EA, Gauhar A, Grüning CS, Willbold D, Härd T, Stoldt M, Hoyer W.

Chembiochem. 2015 Feb 9;16(3):411-4. doi: 10.1002/cbic.201402552. Epub 2014 Dec 30.

PMID:
25557164
13.

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.

Vaikath NN, Majbour NK, Paleologou KE, Ardah MT, van Dam E, van de Berg WD, Forrest SL, Parkkinen L, Gai WP, Hattori N, Takanashi M, Lee SJ, Mann DM, Imai Y, Halliday GM, Li JY, El-Agnaf OM.

Neurobiol Dis. 2015 Jul;79:81-99. doi: 10.1016/j.nbd.2015.04.009. Epub 2015 Apr 30.

PMID:
25937088
14.

Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis.

Jaikaran ET, Higham CE, Serpell LC, Zurdo J, Gross M, Clark A, Fraser PE.

J Mol Biol. 2001 May 4;308(3):515-25.

PMID:
11327784
15.

Pseudocatalytic Antiaggregation Activity of Antibodies: Immunoglobulins can Influence α-Synuclein Aggregation at Substoichiometric Concentrations.

Breydo L, Morgan D, Uversky VN.

Mol Neurobiol. 2016 Apr;53(3):1949-58. doi: 10.1007/s12035-015-9148-8. Epub 2015 Apr 2.

PMID:
25833100
16.

Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis.

Scrocchi LA, Chen Y, Waschuk S, Wang F, Cheung S, Darabie AA, McLaurin J, Fraser PE.

J Mol Biol. 2002 May 3;318(3):697-706.

PMID:
12054816
17.

Laminin inhibition of beta-amyloid protein (Abeta) fibrillogenesis and identification of an Abeta binding site localized to the globular domain repeats on the laminin a chain.

Castillo GM, Lukito W, Peskind E, Raskind M, Kirschner DA, Yee AG, Snow AD.

J Neurosci Res. 2000 Nov 1;62(3):451-62.

PMID:
11054814
18.

A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein.

Du HN, Tang L, Luo XY, Li HT, Hu J, Zhou JW, Hu HY.

Biochemistry. 2003 Jul 29;42(29):8870-8.

PMID:
12873148
19.

A Hot-Segment-Based Approach for the Design of Cross-Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self-Assembly.

Andreetto E, Malideli E, Yan LM, Kracklauer M, Farbiarz K, Tatarek-Nossol M, Rammes G, Prade E, Neumüller T, Caporale A, Spanopoulou A, Bakou M, Reif B, Kapurniotu A.

Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13095-100. doi: 10.1002/anie.201504973. Epub 2015 Sep 4.

PMID:
26336938
20.

Non-Amyloid-β Component of Human α-Synuclein Oligomers Induces Formation of New Aβ Oligomers: Insight into the Mechanisms That Link Parkinson's and Alzheimer's Diseases.

Atsmon-Raz Y, Miller Y.

ACS Chem Neurosci. 2016 Jan 20;7(1):46-55. doi: 10.1021/acschemneuro.5b00204. Epub 2015 Oct 29.

PMID:
26479553

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