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Items: 1 to 20 of 107

1.

RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor.

Rana R, Coulter S, Kinyamu H, Goldstein JA.

Drug Metab Dispos. 2013 Feb;41(2):398-405. doi: 10.1124/dmd.112.048728. Epub 2012 Nov 15.

2.

Threonine-408 Regulates the Stability of Human Pregnane X Receptor through Its Phosphorylation and the CHIP/Chaperone-Autophagy Pathway.

Sugatani J, Noguchi Y, Hattori Y, Yamaguchi M, Yamazaki Y, Ikari A.

Drug Metab Dispos. 2016 Jan;44(1):137-50. doi: 10.1124/dmd.115.066308. Epub 2015 Nov 3.

3.

Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.

Ong SS, Goktug AN, Elias A, Wu J, Saunders D, Chen T.

Biochem J. 2014 Apr 1;459(1):193-203. doi: 10.1042/BJ20130558.

4.

The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor.

Ding X, Lichti K, Staudinger JL.

Toxicol Sci. 2006 Jun;91(2):448-55. Epub 2006 Mar 17.

5.

Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta.

Tatematsu K, Yoshimoto N, Okajima T, Tanizawa K, Kuroda S.

J Biol Chem. 2008 Apr 25;283(17):11575-85. doi: 10.1074/jbc.M706961200. Epub 2008 Feb 25.

6.

Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein.

Sugatani J, Uchida T, Kurosawa M, Yamaguchi M, Yamazaki Y, Ikari A, Miwa M.

Drug Metab Dispos. 2012 Oct;40(10):2031-40. doi: 10.1124/dmd.112.046748. Epub 2012 Jul 24.

7.

3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition.

Antolino-Lobo I, Meulenbelt J, Nijmeijer SM, Maas-Bakker RF, Meijerman I, van den Berg M, van Duursen MB.

Toxicol Lett. 2011 May 30;203(1):82-91. doi: 10.1016/j.toxlet.2011.03.007. Epub 2011 Mar 22.

PMID:
21402137
8.

Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides.

Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TK.

J Pharmacol Exp Ther. 2010 Dec;335(3):771-80. doi: 10.1124/jpet.110.172338. Epub 2010 Aug 25.

9.

Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor.

Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TK.

J Pharmacol Exp Ther. 2011 Mar;336(3):816-26. doi: 10.1124/jpet.110.175927. Epub 2010 Dec 2.

10.

Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents.

Mani S, Huang H, Sundarababu S, Liu W, Kalpana G, Smith AB, Horwitz SB.

Clin Cancer Res. 2005 Sep 1;11(17):6359-69.

11.

U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.

Smutny T, Bitman M, Urban M, Dubecka M, Vrzal R, Dvorak Z, Pavek P.

Arch Toxicol. 2014 Dec;88(12):2243-59. doi: 10.1007/s00204-014-1254-2. Epub 2014 May 14.

PMID:
24819614
12.

Nigramide C is a natural agonist of human pregnane x receptor.

Kanno Y, Yatsu T, Li W, Koike K, Inouye Y.

Drug Metab Dispos. 2014 Jun;42(6):1084-9. doi: 10.1124/dmd.114.057810. Epub 2014 Apr 4.

13.

The E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 targets pancreas transcription factor 1a for proteasomal degradation.

Hanoun N, Fritsch S, Gayet O, Gigoux V, Cordelier P, Dusetti N, Torrisani J, Dufresne M.

J Biol Chem. 2014 Dec 19;289(51):35593-604. doi: 10.1074/jbc.M114.620104. Epub 2014 Oct 29.

15.

Estrogen receptor-α, RBCK1, and protein kinase C β 1 cooperate to regulate estrogen receptor-α gene expression.

Gustafsson Sheppard N, Heldring N, Dahlman-Wright K.

J Mol Endocrinol. 2012 Oct 30;49(3):277-87. doi: 10.1530/JME-12-0073. Print 2012 Dec.

PMID:
23042805
16.

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.

Berndt JD, Aoyagi A, Yang P, Anastas JN, Tang L, Moon RT.

J Cell Biol. 2011 Sep 5;194(5):737-50. doi: 10.1083/jcb.201107021. Epub 2011 Aug 29.

17.

SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes.

Cui W, Sun M, Galeva N, Williams TD, Azuma Y, Staudinger JL.

Drug Metab Dispos. 2015 Sep;43(9):1316-25. doi: 10.1124/dmd.115.065201. Epub 2015 Jun 10.

18.

Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes.

Kojima K, Nagata K, Matsubara T, Yamazoe Y.

Drug Metab Pharmacokinet. 2007 Aug;22(4):276-86.

20.

Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor.

Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O.

Biochem Pharmacol. 2017 Jul 15;136:122-135. doi: 10.1016/j.bcp.2017.04.013. Epub 2017 Apr 13.

PMID:
28414139

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