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Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts.

Gassman NR, Stefanick DF, Kedar PS, Horton JK, Wilson SH.

PLoS One. 2012;7(11):e49301. doi: 10.1371/journal.pone.0049301. Epub 2012 Nov 7.


Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses.

Horton JK, Stefanick DF, Gassman NR, Williams JG, Gabel SA, Cuneo MJ, Prasad R, Kedar PS, Derose EF, Hou EW, London RE, Wilson SH.

DNA Repair (Amst). 2013 Sep;12(9):774-85. doi: 10.1016/j.dnarep.2013.06.004. Epub 2013 Jul 18.


PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways.

Wang M, Wu W, Wu W, Rosidi B, Zhang L, Wang H, Iliakis G.

Nucleic Acids Res. 2006;34(21):6170-82. Epub 2006 Nov 6.


PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks.

Couto CA, Wang HY, Green JC, Kiely R, Siddaway R, Borer C, Pears CJ, Lakin ND.

J Cell Biol. 2011 Aug 8;194(3):367-75. doi: 10.1083/jcb.201012132. Epub 2011 Aug 1.


DNA polymerase β-dependent cell survival independent of XRCC1 expression.

Horton JK, Gassman NR, Dunigan BD, Stefanick DF, Wilson SH.

DNA Repair (Amst). 2015 Feb;26:23-9. doi: 10.1016/j.dnarep.2014.11.008. Epub 2014 Dec 3.


Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation.

Mitchell J, Smith GC, Curtin NJ.

Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1520-7. doi: 10.1016/j.ijrobp.2009.07.1722.


P21-PARP-1 pathway is involved in cigarette smoke-induced lung DNA damage and cellular senescence.

Yao H, Sundar IK, Gorbunova V, Rahman I.

PLoS One. 2013 Nov 11;8(11):e80007. doi: 10.1371/journal.pone.0080007. eCollection 2013.


Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair.

Löser DA, Shibata A, Shibata AK, Woodbine LJ, Jeggo PA, Chalmers AJ.

Mol Cancer Ther. 2010 Jun;9(6):1775-87. doi: 10.1158/1535-7163.MCT-09-1027. Epub 2010 Jun 8.


PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks.

Krietsch J, Caron MC, Gagné JP, Ethier C, Vignard J, Vincent M, Rouleau M, Hendzel MJ, Poirier GG, Masson JY.

Nucleic Acids Res. 2012 Nov 1;40(20):10287-301. doi: 10.1093/nar/gks798. Epub 2012 Aug 31.


Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.

Idogawa M, Masutani M, Shitashige M, Honda K, Tokino T, Shinomura Y, Imai K, Hirohashi S, Yamada T.

Cancer Res. 2007 Feb 1;67(3):911-8.


Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks.

Cheng Q, Barboule N, Frit P, Gomez D, Bombarde O, Couderc B, Ren GS, Salles B, Calsou P.

Nucleic Acids Res. 2011 Dec;39(22):9605-19. doi: 10.1093/nar/gkr656. Epub 2011 Aug 31.


DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining.

Howard SM, Yanez DA, Stark JM.

PLoS Genet. 2015 Jan 28;11(1):e1004943. doi: 10.1371/journal.pgen.1004943. eCollection 2015 Jan.


Histone H2AX is a critical factor for cellular protection against DNA alkylating agents.

Meador JA, Zhao M, Su Y, Narayan G, Geard CR, Balajee AS.

Oncogene. 2008 Sep 25;27(43):5662-71. doi: 10.1038/onc.2008.187. Epub 2008 Jun 9.


Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation.

Hossain MB, Ji P, Anish R, Jacobson RH, Takada S.

J Biol Chem. 2009 Mar 27;284(13):8621-32. doi: 10.1074/jbc.M807198200. Epub 2009 Jan 30.


Changes in expression of the DNA repair protein complex DNA-dependent protein kinase after ischemia and reperfusion.

Shackelford DA, Tobaru T, Zhang S, Zivin JA.

J Neurosci. 1999 Jun 15;19(12):4727-38.


Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.

Dregalla RC, Zhou J, Idate RR, Battaglia CL, Liber HL, Bailey SM.

Aging (Albany NY). 2010 Oct;2(10):691-708.


Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase.

Gao H, Coyle DL, Meyer-Ficca ML, Meyer RG, Jacobson EL, Wang ZQ, Jacobson MK.

Exp Cell Res. 2007 Mar 10;313(5):984-96. Epub 2007 Jan 10.


Topoisomerase IIβ associates with Ku70 and PARP-1 during double strand break repair of DNA in neurons.

Mandraju R, Chekuri A, Bhaskar C, Duning K, Kremerskothen J, Kondapi AK.

Arch Biochem Biophys. 2011 Dec 15;516(2):128-37. doi: 10.1016/ Epub 2011 Oct 10.


Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.

Schreiber V, Amé JC, Dollé P, Schultz I, Rinaldi B, Fraulob V, Ménissier-de Murcia J, de Murcia G.

J Biol Chem. 2002 Jun 21;277(25):23028-36. Epub 2002 Apr 10.

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