Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 100

1.

Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation.

Ke W, Pattanaik P, Bethel CR, Sheri A, Buynak JD, Bonomo RA, van den Akker F.

PLoS One. 2012;7(11):e49035. doi: 10.1371/journal.pone.0049035. Epub 2012 Nov 8.

2.

Crystal structures of KPC-2 β-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226.

Ke W, Bethel CR, Papp-Wallace KM, Pagadala SR, Nottingham M, Fernandez D, Buynak JD, Bonomo RA, van den Akker F.

Antimicrob Agents Chemother. 2012 May;56(5):2713-8. doi: 10.1128/AAC.06099-11. Epub 2012 Feb 13.

3.

Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone.

Padayatti PS, Sheri A, Totir MA, Helfand MS, Carey MP, Anderson VE, Carey PR, Bethel CR, Bonomo RA, Buynak JD, van den Akker F.

J Am Chem Soc. 2006 Oct 11;128(40):13235-42.

4.

Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition.

Rodkey EA, Winkler ML, Bethel CR, Pagadala SR, Buynak JD, Bonomo RA, van den Akker F.

PLoS One. 2014 Jan 16;9(1):e85892. doi: 10.1371/journal.pone.0085892. eCollection 2014.

5.

Inhibition of OXA-1 beta-lactamase by penems.

Bethel CR, Distler AM, Ruszczycky MW, Carey MP, Carey PR, Hujer AM, Taracila M, Helfand MS, Thomson JM, Kalp M, Anderson VE, Leonard DA, Hujer KM, Abe T, Venkatesan AM, Mansour TS, Bonomo RA.

Antimicrob Agents Chemother. 2008 Sep;52(9):3135-43. doi: 10.1128/AAC.01677-07. Epub 2008 Jun 16.

6.

Inhibition of class A beta-lactamases by carbapenems: crystallographic observation of two conformations of meropenem in SHV-1.

Nukaga M, Bethel CR, Thomson JM, Hujer AM, Distler A, Anderson VE, Knox JR, Bonomo RA.

J Am Chem Soc. 2008 Sep 24;130(38):12656-62. doi: 10.1021/ja7111146. Epub 2008 Aug 30.

7.

Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.

Helfand MS, Taracila MA, Totir MA, Bonomo RA, Buynak JD, van den Akker F, Carey PR.

Biochemistry. 2007 Jul 24;46(29):8689-99. Epub 2007 Jun 27.

PMID:
17595114
8.

Penicillin sulfone inhibitors of class D beta-lactamases.

Drawz SM, Bethel CR, Doppalapudi VR, Sheri A, Pagadala SR, Hujer AM, Skalweit MJ, Anderson VE, Chen SG, Buynak JD, Bonomo RA.

Antimicrob Agents Chemother. 2010 Apr;54(4):1414-24. doi: 10.1128/AAC.00743-09. Epub 2010 Jan 19.

9.

Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.

Bou G, Santillana E, Sheri A, Beceiro A, Sampson JM, Kalp M, Bethel CR, Distler AM, Drawz SM, Pagadala SR, van den Akker F, Bonomo RA, Romero A, Buynak JD.

J Am Chem Soc. 2010 Sep 29;132(38):13320-31. doi: 10.1021/ja104092z.

10.

Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.

Papp-Wallace KM, Bethel CR, Distler AM, Kasuboski C, Taracila M, Bonomo RA.

Antimicrob Agents Chemother. 2010 Feb;54(2):890-7. doi: 10.1128/AAC.00693-09. Epub 2009 Dec 14.

11.

Synthesis and biological evaluation of penam sulfones as inhibitors of beta-lactamases.

Phillips OA, Reddy AV, Setti EL, Spevak P, Czajkowski DP, Atwal H, Salama S, Micetich RG, Maiti SN.

Bioorg Med Chem. 2005 Apr 15;13(8):2847-58. Erratum in: Bioorg Med Chem. 2005 Nov 15;13(22):6276.

PMID:
15781395
12.

Inactivation of the RTEM beta-lactamase from Escherichia coli. Interaction of penam sulfones with enzyme.

Fisher J, Charnas RL, Bradley SM, Knowles JR.

Biochemistry. 1981 May 12;20(10):2726-31.

PMID:
7018564
13.

Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam.

Kuzin AP, Nukaga M, Nukaga Y, Hujer A, Bonomo RA, Knox JR.

Biochemistry. 2001 Feb 13;40(6):1861-6.

PMID:
11327849
14.

Crystal Structures of KPC-2 and SHV-1 β-Lactamases in Complex with the Boronic Acid Transition State Analog S02030.

Nguyen NQ, Krishnan NP, Rojas LJ, Prati F, Caselli E, Romagnoli C, Bonomo RA, van den Akker F.

Antimicrob Agents Chemother. 2016 Jan 4;60(3):1760-6. doi: 10.1128/AAC.02643-15.

15.

High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase.

Padayatti PS, Helfand MS, Totir MA, Carey MP, Carey PR, Bonomo RA, van den Akker F.

J Biol Chem. 2005 Oct 14;280(41):34900-7. Epub 2005 Jul 29.

16.

Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone.

Pattanaik P, Bethel CR, Hujer AM, Hujer KM, Distler AM, Taracila M, Anderson VE, Fritsche TR, Jones RN, Pagadala SR, van den Akker F, Buynak JD, Bonomo RA.

J Biol Chem. 2009 Jan 9;284(2):945-53. doi: 10.1074/jbc.M806833200. Epub 2008 Oct 27.

17.
18.

Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems.

Bethel CR, Taracila M, Shyr T, Thomson JM, Distler AM, Hujer KM, Hujer AM, Endimiani A, Papp-Wallace K, Bonnet R, Bonomo RA.

Antimicrob Agents Chemother. 2011 Jul;55(7):3465-75. doi: 10.1128/AAC.00089-11. Epub 2011 May 9.

19.

Crystal structures of the class D beta-lactamase OXA-13 in the native form and in complex with meropenem.

Pernot L, Frénois F, Rybkine T, L'Hermite G, Petrella S, Delettré J, Jarlier V, Collatz E, Sougakoff W.

J Mol Biol. 2001 Jul 20;310(4):859-74.

PMID:
11453693
20.

Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.

Sandanayaka VP, Feigelson GB, Prashad AS, Yang Y, Petersen PJ.

Bioorg Med Chem Lett. 2001 Apr 23;11(8):997-1000. Erratum in: Bioorg Med Chem Lett 2001 Jul 23;11(14):1963.

PMID:
11327608

Supplemental Content

Support Center