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Items: 1 to 20 of 151

1.

Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.

Li J, Kanekiyo T, Shinohara M, Zhang Y, LaDu MJ, Xu H, Bu G.

J Biol Chem. 2012 Dec 28;287(53):44593-601. doi: 10.1074/jbc.M112.420224. Epub 2012 Nov 6.

2.

Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels.

Lee CY, Tse W, Smith JD, Landreth GE.

J Biol Chem. 2012 Jan 13;287(3):2032-44. doi: 10.1074/jbc.M111.295451. Epub 2011 Nov 30.

3.

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.

Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV.

J Clin Invest. 2008 Dec;118(12):4002-13. doi: 10.1172/JCI36663. Epub 2008 Nov 13.

4.

Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide.

Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT.

J Neurosci. 2012 Oct 24;32(43):15181-92. doi: 10.1523/JNEUROSCI.1542-12.2012.

5.

Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits.

Belinson H, Lev D, Masliah E, Michaelson DM.

J Neurosci. 2008 Apr 30;28(18):4690-701. doi: 10.1523/JNEUROSCI.5633-07.2008.

6.

Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice.

Xu F, Vitek MP, Colton CA, Previti ML, Gharkholonarehe N, Davis J, Van Nostrand WE.

J Neurosci. 2008 May 14;28(20):5312-20. doi: 10.1523/JNEUROSCI.1042-08.2008.

7.

Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.

Fitz NF, Cronican AA, Saleem M, Fauq AH, Chapman R, Lefterov I, Koldamova R.

J Neurosci. 2012 Sep 19;32(38):13125-36.

8.

Regulation of angiotensin II type 1A receptor intracellular retention, degradation, and recycling by Rab5, Rab7, and Rab11 GTPases.

Dale LB, Seachrist JL, Babwah AV, Ferguson SS.

J Biol Chem. 2004 Mar 26;279(13):13110-8. Epub 2004 Jan 7.

9.

Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex.

Arold S, Sullivan P, Bilousova T, Teng E, Miller CA, Poon WW, Vinters HV, Cornwell LB, Saing T, Cole GM, Gylys KH.

Acta Neuropathol. 2012 Jan;123(1):39-52. doi: 10.1007/s00401-011-0892-1. Epub 2011 Oct 22.

10.

Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation.

Levi O, Dolev I, Belinson H, Michaelson DM.

J Neurochem. 2007 Nov;103(3):1031-40. Epub 2007 Jul 31.

11.
12.

Inhibition of β-amyloid1-42 internalization attenuates neuronal death by stabilizing the endosomal-lysosomal system in rat cortical cultured neurons.

Song MS, Baker GB, Todd KG, Kar S.

Neuroscience. 2011 Mar 31;178:181-8. doi: 10.1016/j.neuroscience.2010.12.055. Epub 2011 Jan 21.

PMID:
21262324
13.

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.

Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM.

Sci Transl Med. 2011 Jun 29;3(89):89ra57. doi: 10.1126/scitranslmed.3002156.

14.
15.

High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.

Cerf E, Gustot A, Goormaghtigh E, Ruysschaert JM, Raussens V.

FASEB J. 2011 May;25(5):1585-95. doi: 10.1096/fj.10-175976. Epub 2011 Jan 25.

PMID:
21266538
16.

APOE modulates the effect of estrogen therapy on Aβ accumulation EFAD-Tg mice.

Kunzler J, Youmans KL, Yu C, Ladu MJ, Tai LM.

Neurosci Lett. 2014 Feb 7;560:131-6. doi: 10.1016/j.neulet.2013.12.032. Epub 2013 Dec 22.

17.

Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples.

Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, Ladu MJ.

J Biol Chem. 2013 Feb 22;288(8):5914-26. doi: 10.1074/jbc.M112.442103. Epub 2013 Jan 4.

18.
19.

Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration.

Belinson H, Kariv-Inbal Z, Kayed R, Masliah E, Michaelson DM.

J Alzheimers Dis. 2010;22(3):959-70. doi: 10.3233/JAD-2010-101008.

20.

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