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Items: 1 to 20 of 89

1.

Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2.

Shi K, Kurahashi K, Gao R, Tsutakawa SE, Tainer JA, Pommier Y, Aihara H.

Nat Struct Mol Biol. 2012 Dec;19(12):1372-7. doi: 10.1038/nsmb.2423. Epub 2012 Oct 28.

2.

Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.

Schellenberg MJ, Perera L, Strom CN, Waters CA, Monian B, Appel CD, Vilas CK, Williams JG, Ramsden DA, Williams RS.

Nucleic Acids Res. 2016 May 5;44(8):3829-44. doi: 10.1093/nar/gkw228. Epub 2016 Apr 8.

3.
4.

Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage.

Rao T, Gao R, Takada S, Al Abo M, Chen X, Walters KJ, Pommier Y, Aihara H.

Nucleic Acids Res. 2016 Dec 1;44(21):10201-10215. Epub 2016 Aug 19.

5.

Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2┬ĚDNA and Top2┬ĚRNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).

Gao R, Schellenberg MJ, Huang SY, Abdelmalak M, Marchand C, Nitiss KC, Nitiss JL, Williams RS, Pommier Y.

J Biol Chem. 2014 Jun 27;289(26):17960-9. doi: 10.1074/jbc.M114.565374. Epub 2014 May 7.

6.

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).

Pommier Y, Huang SY, Gao R, Das BB, Murai J, Marchand C.

DNA Repair (Amst). 2014 Jul;19:114-29. doi: 10.1016/j.dnarep.2014.03.020. Epub 2014 May 22. Review.

7.

Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.

Marchand C, Abdelmalak M, Kankanala J, Huang SY, Kiselev E, Fesen K, Kurahashi K, Sasanuma H, Takeda S, Aihara H, Wang Z, Pommier Y.

ACS Chem Biol. 2016 Jul 15;11(7):1925-33. doi: 10.1021/acschembio.5b01047. Epub 2016 May 11.

PMID:
27128689
8.

Pleiotropic functions of EAPII/TTRAP/TDP2: cancer development, chemoresistance and beyond.

Li C, Sun SY, Khuri FR, Li R.

Cell Cycle. 2011 Oct 1;10(19):3274-83. doi: 10.4161/cc.10.19.17763. Epub 2011 Oct 1. Review.

9.

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW, El-Khamisy SF.

Nucleic Acids Res. 2012 Sep 1;40(17):8371-80. Epub 2012 Jun 26.

10.

Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.

Schellenberg MJ, Appel CD, Adhikari S, Robertson PD, Ramsden DA, Williams RS.

Nat Struct Mol Biol. 2012 Dec;19(12):1363-71. doi: 10.1038/nsmb.2418. Epub 2012 Oct 28.

11.

VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization and proteolytic cleavage.

Maciejewski S, Ullmer W, Semler BL.

Virology. 2018 Mar;516:139-146. doi: 10.1016/j.virol.2018.01.010. Epub 2018 Jan 30.

PMID:
29353210
12.

An RNA virus hijacks an incognito function of a DNA repair enzyme.

Virgen-Slane R, Rozovics JM, Fitzgerald KD, Ngo T, Chou W, van der Heden van Noort GJ, Filippov DV, Gershon PD, Semler BL.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14634-9. doi: 10.1073/pnas.1208096109. Epub 2012 Aug 20.

13.

Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft.

Kossmann BR, Abdelmalak M, Lopez S, Tender G, Yan C, Pommier Y, Marchand C, Ivanov I.

Bioorg Med Chem Lett. 2016 Jul 15;26(14):3232-3236. doi: 10.1016/j.bmcl.2016.05.065. Epub 2016 May 24.

14.

Development of a novel assay for human tyrosyl DNA phosphodiesterase 2.

Adhikari S, Karmahapatra SK, Elias H, Dhopeshwarkar P, Williams RS, Byers S, Uren A, Roy R.

Anal Biochem. 2011 Sep 1;416(1):112-6. doi: 10.1016/j.ab.2011.05.008. Epub 2011 May 12.

15.

Synthesis and structure-activity relationship of furoquinolinediones as inhibitors of Tyrosyl-DNA phosphodiesterase 2 (TDP2).

Yu LM, Hu Z, Chen Y, Ravji A, Lopez S, Plescia CB, Yu Q, Yang H, Abdelmalak M, Saha S, Agama K, Kiselev E, Marchand C, Pommier Y, An LK.

Eur J Med Chem. 2018 May 10;151:777-796. doi: 10.1016/j.ejmech.2018.04.024. Epub 2018 Apr 12.

PMID:
29677635
16.

Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose.

Caldecott KW.

Nat Struct Mol Biol. 2012 Dec;19(12):1212-3. doi: 10.1038/nsmb.2455. No abstract available.

PMID:
23211766
17.

ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells.

Bian K, Muppani NR, Elkhadragy L, Wang W, Zhang C, Chen T, Jung S, Seternes OM, Long W.

Oncotarget. 2016 Feb 9;7(6):6665-75. doi: 10.18632/oncotarget.6682.

18.

Crystal structure of the human Fe65-PTB1 domain.

Radzimanowski J, Ravaud S, Schlesinger S, Koch J, Beyreuther K, Sinning I, Wild K.

J Biol Chem. 2008 Aug 22;283(34):23113-20. doi: 10.1074/jbc.M800861200. Epub 2008 Jun 11.

19.

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.

Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett NC, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, Caldecott KW, Oliver AW.

Biochem J. 2016 Jul 1;473(13):1869-79. doi: 10.1042/BCJ20160180. Epub 2016 Apr 20.

20.

Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2).

Kankanala J, Marchand C, Abdelmalak M, Aihara H, Pommier Y, Wang Z.

J Med Chem. 2016 Mar 24;59(6):2734-46. doi: 10.1021/acs.jmedchem.5b01973. Epub 2016 Mar 7.

PMID:
26910725

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