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Structural insight into HIV-1 capsid recognition by rhesus TRIM5α.

Yang H, Ji X, Zhao G, Ning J, Zhao Q, Aiken C, Gronenborn AM, Zhang P, Xiong Y.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18372-7. doi: 10.1073/pnas.1210903109. Epub 2012 Oct 22.


Structure of the rhesus monkey TRIM5α PRYSPRY domain, the HIV capsid recognition module.

Biris N, Yang Y, Taylor AB, Tomashevski A, Guo M, Hart PJ, Diaz-Griffero F, Ivanov DN.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13278-83. doi: 10.1073/pnas.1203536109. Epub 2012 Jul 30.


Rhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfaces.

Zhao G, Ke D, Vu T, Ahn J, Shah VB, Yang R, Aiken C, Charlton LM, Gronenborn AM, Zhang P.

PLoS Pathog. 2011 Mar;7(3):e1002009. doi: 10.1371/journal.ppat.1002009. Epub 2011 Mar 24.


Rhesus monkey TRIM5α SPRY domain recognizes multiple epitopes that span several capsid monomers on the surface of the HIV-1 mature viral core.

Biris N, Tomashevski A, Bhattacharya A, Diaz-Griffero F, Ivanov DN.

J Mol Biol. 2013 Dec 13;425(24):5032-44. doi: 10.1016/j.jmb.2013.07.025. Epub 2013 Jul 23.


Hexagonal assembly of a restricting TRIM5alpha protein.

Ganser-Pornillos BK, Chandrasekaran V, Pornillos O, Sodroski JG, Sundquist WI, Yeager M.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):534-9. doi: 10.1073/pnas.1013426108. Epub 2010 Dec 27.


CryoEM analysis of capsid assembly and structural changes upon interactions with a host restriction factor, TRIM5α.

Zhao G, Zhang P.

Methods Mol Biol. 2014;1087:13-28. doi: 10.1007/978-1-62703-670-2_2.


Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α.

Wagner JM, Roganowicz MD, Skorupka K, Alam SL, Christensen D, Doss G, Wan Y, Frank GA, Ganser-Pornillos BK, Sundquist WI, Pornillos O.

Elife. 2016 Jun 2;5. pii: e16309. doi: 10.7554/eLife.16309.


The TRIM5alpha B-box 2 domain promotes cooperative binding to the retroviral capsid by mediating higher-order self-association.

Li X, Sodroski J.

J Virol. 2008 Dec;82(23):11495-502. doi: 10.1128/JVI.01548-08. Epub 2008 Sep 17.


Virus-specific effects of TRIM5α(rh) RING domain functions on restriction of retroviruses.

Li X, Kim J, Song B, Finzi A, Pacheco B, Sodroski J.

J Virol. 2013 Jul;87(13):7234-45. doi: 10.1128/JVI.00620-13. Epub 2013 May 1.


Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction.

Yang Y, Brandariz-Nuñez A, Fricke T, Ivanov DN, Sarnak Z, Diaz-Griffero F.

Virology. 2014 Jan 5;448:217-28. doi: 10.1016/j.virol.2013.10.012. Epub 2013 Oct 31.


Retroviral restriction factors TRIM5α: therapeutic strategy to inhibit HIV-1 replication.

Zhang J, Ge W, Zhan P, De Clercq E, Liu X.

Curr Med Chem. 2011;18(17):2649-54. Review.


Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region.

Sastri J, Johnsen L, Smolin N, Imam S, Mukherjee S, Lukic Z, Brandariz-Nuñez A, Robia SL, Diaz-Griffero F, Wiethoff C, Campbell EM.

J Virol. 2014 Aug;88(16):8911-23. doi: 10.1128/JVI.01134-14. Epub 2014 May 28.


A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction.

Diaz-Griffero F, Qin XR, Hayashi F, Kigawa T, Finzi A, Sarnak Z, Lienlaf M, Yokoyama S, Sodroski J.

J Virol. 2009 Oct;83(20):10737-51. doi: 10.1128/JVI.01307-09. Epub 2009 Aug 5.


Functional interplay between the B-box 2 and the B30.2(SPRY) domains of TRIM5alpha.

Li X, Song B, Xiang SH, Sodroski J.

Virology. 2007 Sep 30;366(2):234-44. Epub 2007 May 31.


Recognition of the HIV capsid by the TRIM5α restriction factor is mediated by a subset of pre-existing conformations of the TRIM5α SPRY domain.

Kovalskyy DB, Ivanov DN.

Biochemistry. 2014 Mar 11;53(9):1466-76. doi: 10.1021/bi4014962. Epub 2014 Feb 24.


Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor.

Stremlau M, Perron M, Lee M, Li Y, Song B, Javanbakht H, Diaz-Griffero F, Anderson DJ, Sundquist WI, Sodroski J.

Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5514-9. Epub 2006 Mar 15.


TRIM5α Degradation via Autophagy Is Not Required for Retroviral Restriction.

Imam S, Talley S, Nelson RS, Dharan A, O'Connor C, Hope TJ, Campbell EM.

J Virol. 2016 Jan 13;90(7):3400-10. doi: 10.1128/JVI.03033-15.


Characterization of TRIM5alpha trimerization and its contribution to human immunodeficiency virus capsid binding.

Javanbakht H, Yuan W, Yeung DF, Song B, Diaz-Griffero F, Li Y, Li X, Stremlau M, Sodroski J.

Virology. 2006 Sep 15;353(1):234-46. Epub 2006 Jun 30.

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