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Items: 1 to 20 of 96


Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.

Mitchell PS, Patzina C, Emerman M, Haller O, Malik HS, Kochs G.

Cell Host Microbe. 2012 Oct 18;12(4):598-604. doi: 10.1016/j.chom.2012.09.005.


Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influenza A virus.

Patzina C, Haller O, Kochs G.

J Biol Chem. 2014 Feb 28;289(9):6020-7. doi: 10.1074/jbc.M113.543892.


Role of nucleotide binding and GTPase domain dimerization in dynamin-like myxovirus resistance protein A for GTPase activation and antiviral activity.

Dick A, Graf L, Olal D, von der Malsburg A, Gao S, Kochs G, Daumke O.

J Biol Chem. 2015 May 15;290(20):12779-92. doi: 10.1074/jbc.M115.650325.


Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses.

Verhelst J, Spitaels J, N├╝rnberger C, De Vlieger D, Ysenbaert T, Staeheli P, Fiers W, Saelens X.

J Virol. 2015 Nov;89(21):10879-90. doi: 10.1128/JVI.01744-15.


Mx GTPases: dynamin-like antiviral machines of innate immunity.

Haller O, Staeheli P, Schwemmle M, Kochs G.

Trends Microbiol. 2015 Mar;23(3):154-63. doi: 10.1016/j.tim.2014.12.003. Review.


Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity.

Haller O, Kochs G.

J Interferon Cytokine Res. 2011 Jan;31(1):79-87. doi: 10.1089/jir.2010.0076. Review.


Oligomerization and GTP-binding Requirements of MxA for Viral Target Recognition and Antiviral Activity against Influenza A Virus.

Nigg PE, Pavlovic J.

J Biol Chem. 2015 Dec 11;290(50):29893-906. doi: 10.1074/jbc.M115.681494.


Myxovirus resistance gene A (MxA) expression suppresses influenza A virus replication in alpha interferon-treated primate cells.

Matzinger SR, Carroll TD, Dutra JC, Ma ZM, Miller CJ.

J Virol. 2013 Jan;87(2):1150-8. doi: 10.1128/JVI.02271-12.


Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction.

Mitchell PS, Young JM, Emerman M, Malik HS.

PLoS Pathog. 2015 Dec 10;11(12):e1005304. doi: 10.1371/journal.ppat.1005304.


An evolutionary perspective on the broad antiviral specificity of MxA.

Mitchell PS, Emerman M, Malik HS.

Curr Opin Microbiol. 2013 Aug;16(4):493-9. doi: 10.1016/j.mib.2013.04.005. Review.


Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity.

Haller O, Gao S, von der Malsburg A, Daumke O, Kochs G.

J Biol Chem. 2010 Sep 10;285(37):28419-24. doi: 10.1074/jbc.R110.145839. Review.


Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus.

Frese M, Kochs G, Meier-Dieter U, Siebler J, Haller O.

J Virol. 1995 Jun;69(6):3904-9.


Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections.

Hefti HP, Frese M, Landis H, Di Paolo C, Aguzzi A, Haller O, Pavlovic J.

J Virol. 1999 Aug;73(8):6984-91.


The cytoplasmic location of chicken mx is not the determining factor for its lack of antiviral activity.

Benfield CT, Lyall JW, Tiley LS.

PLoS One. 2010 Aug 16;5(8):e12151. doi: 10.1371/journal.pone.0012151.


Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids.

Kochs G, Haller O.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2082-6.


Human/bovine chimeric MxA-like GTPases reveal a contribution of N-terminal domains to the magnitude of anti-influenza A activity.

Garigliany MM, Cornet A, Desmecht D.

J Interferon Cytokine Res. 2012 Jul;32(7):326-31. doi: 10.1089/jir.2011.0106.


A monomeric GTPase-negative MxA mutant with antiviral activity.

Janzen C, Kochs G, Haller O.

J Virol. 2000 Sep;74(17):8202-6.


Mx1 but not MxA confers resistance against tick-borne Dhori virus in mice.

Thimme R, Frese M, Kochs G, Haller O.

Virology. 1995 Aug 1;211(1):296-301.

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