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Items: 1 to 20 of 90

1.

TAp63 is a master transcriptional regulator of lipid and glucose metabolism.

Su X, Gi YJ, Chakravarti D, Chan IL, Zhang A, Xia X, Tsai KY, Flores ER.

Cell Metab. 2012 Oct 3;16(4):511-25. doi: 10.1016/j.cmet.2012.09.006.

2.

SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.

Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M.

J Biol Chem. 2008 Jul 18;283(29):20015-26. doi: 10.1074/jbc.M802187200.

3.

α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase.

Chen WL, Kang CH, Wang SG, Lee HM.

Diabetologia. 2012 Jun;55(6):1824-35. doi: 10.1007/s00125-012-2530-4.

PMID:
22456698
4.

Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice.

Lee J, Hong SW, Chae SW, Kim DH, Choi JH, Bae JC, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Kim SW, Lee WY.

PLoS One. 2012;7(2):e31394. doi: 10.1371/journal.pone.0031394.

5.

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway.

Chau MD, Gao J, Yang Q, Wu Z, Gromada J.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12553-8. doi: 10.1073/pnas.1006962107.

6.

3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent pathway.

Pil Hwang Y, Gyun Kim H, Choi JH, Truong Do M, Tran TP, Chun HK, Chung YC, Jeong TC, Jeong HG.

Mol Nutr Food Res. 2013 Mar;57(3):471-82. doi: 10.1002/mnfr.201200529.

PMID:
23349077
7.

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.

Cantó C, Jiang LQ, Deshmukh AS, Mataki C, Coste A, Lagouge M, Zierath JR, Auwerx J.

Cell Metab. 2010 Mar 3;11(3):213-9. doi: 10.1016/j.cmet.2010.02.006.

8.

LKB1 regulates lipid oxidation during exercise independently of AMPK.

Jeppesen J, Maarbjerg SJ, Jordy AB, Fritzen AM, Pehmøller C, Sylow L, Serup AK, Jessen N, Thorsen K, Prats C, Qvortrup K, Dyck JR, Hunter RW, Sakamoto K, Thomson DM, Schjerling P, Wojtaszewski JF, Richter EA, Kiens B.

Diabetes. 2013 May;62(5):1490-9. doi: 10.2337/db12-1160.

9.

Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.

Li Y, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M.

Gastroenterology. 2014 Feb;146(2):539-49.e7. doi: 10.1053/j.gastro.2013.10.059.

10.

Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice.

Noda K, Nakajima S, Godo S, Saito H, Ikeda S, Shimizu T, Enkhjargal B, Fukumoto Y, Tsukita S, Yamada T, Katagiri H, Shimokawa H.

PLoS One. 2014 Nov 3;9(11):e110446. doi: 10.1371/journal.pone.0110446.

11.

Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice.

Fu L, Bruckbauer A, Li F, Cao Q, Cui X, Wu R, Shi H, Zemel MB, Xue B.

Metabolism. 2015 Jul;64(7):845-56. doi: 10.1016/j.metabol.2015.03.007.

PMID:
25858853
12.

Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1-AMPK signaling pathway.

Yu JW, Sun LJ, Liu W, Zhao YH, Kang P, Yan BZ.

Int J Infect Dis. 2013 Jul;17(7):e539-45. doi: 10.1016/j.ijid.2013.01.027.

13.

Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.

Rodgers JT, Puigserver P.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12861-6.

14.

Does LKB1 mediate activation of hepatic AMP-protein kinase (AMPK) and sirtuin1 (SIRT1) after Roux-en-Y gastric bypass in obese rats?

Peng Y, Rideout DA, Rakita SS, Gower WR Jr, You M, Murr MM.

J Gastrointest Surg. 2010 Feb;14(2):221-8. doi: 10.1007/s11605-009-1102-5.

PMID:
19937189
15.

SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells.

Zu Y, Liu L, Lee MY, Xu C, Liang Y, Man RY, Vanhoutte PM, Wang Y.

Circ Res. 2010 Apr 30;106(8):1384-93. doi: 10.1161/CIRCRESAHA.109.215483.

16.

Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex.

Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P.

J Biol Chem. 2013 Mar 8;288(10):7117-26. doi: 10.1074/jbc.M112.415729.

17.

Muscle-selective knockout of AMPKα2 does not exacerbate diet-induced obesity probably related to altered myokines expression.

Chen T, Li Z, Zhang Y, Feng F, Wang X, Wang X, Shen QW.

Biochem Biophys Res Commun. 2015 Mar 13;458(3):449-55. doi: 10.1016/j.bbrc.2015.01.075.

PMID:
25637528
18.

AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation.

Zhang YL, Guo H, Zhang CS, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC.

Cell Metab. 2013 Oct 1;18(4):546-55. doi: 10.1016/j.cmet.2013.09.005.

19.

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1α axis in db/db mice.

Kim MY, Lim JH, Youn HH, Hong YA, Yang KS, Park HS, Chung S, Ko SH, Shin SJ, Choi BS, Kim HW, Kim YS, Lee JH, Chang YS, Park CW.

Diabetologia. 2013 Jan;56(1):204-17. doi: 10.1007/s00125-012-2747-2. Erratum in: Diabetologia. 2013 Mar;56(3):681. Koh, S H [corrected to Ko, S H].

PMID:
23090186
20.

Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling.

Miller RA, Chu Q, Le Lay J, Scherer PE, Ahima RS, Kaestner KH, Foretz M, Viollet B, Birnbaum MJ.

J Clin Invest. 2011 Jun;121(6):2518-28. doi: 10.1172/JCI45942.

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