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Items: 1 to 20 of 86

1.

Short-term akt activation in cardiac muscle cells improves contractile function in failing hearts.

Shiojima I, Schiekofer S, Schneider JG, Belisle K, Sato K, Andrassy M, Galasso G, Walsh K.

Am J Pathol. 2012 Dec;181(6):1969-76. doi: 10.1016/j.ajpath.2012.08.020. Epub 2012 Sep 30.

2.

Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure.

Schiekofer S, Shiojima I, Sato K, Galasso G, Oshima Y, Walsh K.

Physiol Genomics. 2006 Oct 11;27(2):156-70. Epub 2006 Aug 1.

3.

RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.

Lauriol J, Keith K, Jaffré F, Couvillon A, Saci A, Goonasekera SA, McCarthy JR, Kessinger CW, Wang J, Ke Q, Kang PM, Molkentin JD, Carpenter C, Kontaridis MI.

Sci Signal. 2014 Oct 21;7(348):ra100. doi: 10.1126/scisignal.2005262.

4.

Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy.

Kemi OJ, Ceci M, Wisloff U, Grimaldi S, Gallo P, Smith GL, Condorelli G, Ellingsen O.

J Cell Physiol. 2008 Feb;214(2):316-21.

PMID:
17941081
5.

The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure.

Xu N, Guan S, Chen Z, Yu Y, Xie J, Pan FY, Zhao NW, Liu L, Yang ZZ, Gao X, Xu B, Li CJ.

J Pathol. 2015 Apr;235(5):672-85. doi: 10.1002/path.4480. Epub 2015 Jan 7.

PMID:
25385233
6.

Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure.

Shiojima I, Sato K, Izumiya Y, Schiekofer S, Ito M, Liao R, Colucci WS, Walsh K.

J Clin Invest. 2005 Aug;115(8):2108-18.

7.

In vivo cardiac role of migfilin during experimental pressure overload.

Haubner BJ, Moik D, Schuetz T, Reiner MF, Voelkl JG, Streil K, Bader K, Zhao L, Scheu C, Mair J, Pachinger O, Metzler B.

Cardiovasc Res. 2015 Jun 1;106(3):398-407. doi: 10.1093/cvr/cvv125. Epub 2015 Apr 7.

PMID:
25852081
8.

Transcriptional effects of chronic Akt activation in the heart.

Cook SA, Matsui T, Li L, Rosenzweig A.

J Biol Chem. 2002 Jun 21;277(25):22528-33. Epub 2002 Apr 15.

9.

NFAT transcription factor regulation by urocortin II in cardiac myocytes and heart failure.

Walther S, Awad S, Lonchyna VA, Blatter LA.

Am J Physiol Heart Circ Physiol. 2014 Mar;306(6):H856-66. doi: 10.1152/ajpheart.00353.2013. Epub 2014 Jan 17.

10.

Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes.

Gao MH, Tang T, Guo T, Miyanohara A, Yajima T, Pestonjamasp K, Feramisco JR, Hammond HK.

J Biol Chem. 2008 Nov 28;283(48):33527-35. doi: 10.1074/jbc.M805825200. Epub 2008 Oct 5.

11.

Manipulation of cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates cardiomyocyte death during doxorubicin-induced cardiomyopathy.

Kitamura Y, Koide M, Akakabe Y, Matsuo K, Shimoda Y, Soma Y, Ogata T, Ueyama T, Matoba S, Yamada H, Ikeda K.

J Biol Chem. 2014 Jan 31;289(5):2788-800. doi: 10.1074/jbc.M113.508143. Epub 2013 Dec 13.

12.

Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes.

Liu L, Zhao X, Pierre SV, Askari A.

Am J Physiol Cell Physiol. 2007 Nov;293(5):C1489-97. Epub 2007 Aug 29.

13.

Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure.

Nakamura TY, Iwata Y, Arai Y, Komamura K, Wakabayashi S.

Circ Res. 2008 Oct 10;103(8):891-9. doi: 10.1161/CIRCRESAHA.108.175141. Epub 2008 Sep 5.

14.

Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation.

Zhu Y, Pereira RO, O'Neill BT, Riehle C, Ilkun O, Wende AR, Rawlings TA, Zhang YC, Zhang Q, Klip A, Shiojima I, Walsh K, Abel ED.

Mol Endocrinol. 2013 Jan;27(1):172-84. doi: 10.1210/me.2012-1210. Epub 2012 Nov 30.

15.

Exercise training and PI3Kα-induced electrical remodeling is independent of cellular hypertrophy and Akt signaling.

Yang KC, Tseng YT, Nerbonne JM.

J Mol Cell Cardiol. 2012 Oct;53(4):532-41. doi: 10.1016/j.yjmcc.2012.07.004. Epub 2012 Jul 21.

16.

Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice.

Oliveira RS, Ferreira JC, Gomes ER, Paixão NA, Rolim NP, Medeiros A, Guatimosim S, Brum PC.

J Physiol. 2009 Aug 1;587(Pt 15):3899-910. doi: 10.1113/jphysiol.2009.173948. Epub 2009 Jun 8.

17.

Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes.

Shiraishi I, Melendez J, Ahn Y, Skavdahl M, Murphy E, Welch S, Schaefer E, Walsh K, Rosenzweig A, Torella D, Nurzynska D, Kajstura J, Leri A, Anversa P, Sussman MA.

Circ Res. 2004 Apr 16;94(7):884-91. Epub 2004 Feb 26.

18.

Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.

Guo D, Kassiri Z, Basu R, Chow FL, Kandalam V, Damilano F, Liang W, Izumo S, Hirsch E, Penninger JM, Backx PH, Oudit GY.

Circ Res. 2010 Nov 12;107(10):1275-89. doi: 10.1161/CIRCRESAHA.110.229054. Epub 2010 Sep 16.

19.

Positive inotropic effect of insulin-like growth factor-1 on normal and failing cardiac myocytes.

Kinugawa S, Tsutsui H, Ide T, Nakamura R, Arimura K, Egashira K, Takeshita A.

Cardiovasc Res. 1999 Jul;43(1):157-64.

PMID:
10536700
20.

AKT signalling in the failing heart.

Chaanine AH, Hajjar RJ.

Eur J Heart Fail. 2011 Aug;13(8):825-9. doi: 10.1093/eurjhf/hfr080. Epub 2011 Jun 30. Review.

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