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Items: 1 to 20 of 126

1.

Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children.

Tandon R, Giret MT, Sengupta D, York VA, Wiznia AA, Rosenberg MG, Kallas EG, Ndhlovu LC, Nixon DF.

PLoS One. 2012;7(9):e45733. doi: 10.1371/journal.pone.0045733. Epub 2012 Sep 24.

2.

HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression.

Vali B, Jones RB, Sakhdari A, Sheth PM, Clayton K, Yue FY, Gyenes G, Wong D, Klein MB, Saeed S, Benko E, Kovacs C, Kaul R, Ostrowski MA.

Eur J Immunol. 2010 Sep;40(9):2493-505. doi: 10.1002/eji.201040340.

3.

Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection.

Sakhdari A, Mujib S, Vali B, Yue FY, MacParland S, Clayton K, Jones RB, Liu J, Lee EY, Benko E, Kovacs C, Gommerman J, Kaul R, Ostrowski MA.

PLoS One. 2012;7(7):e40146. doi: 10.1371/journal.pone.0040146. Epub 2012 Jul 5.

4.

TIM-3 does not act as a receptor for galectin-9.

Leitner J, Rieger A, Pickl WF, Zlabinger G, Grabmeier-Pfistershammer K, Steinberger P.

PLoS Pathog. 2013 Mar;9(3):e1003253. doi: 10.1371/journal.ppat.1003253. Epub 2013 Mar 21.

5.

Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection.

Hoffmann M, Pantazis N, Martin GE, Hickling S, Hurst J, Meyerowitz J, Willberg CB, Robinson N, Brown H, Fisher M, Kinloch S, Babiker A, Weber J, Nwokolo N, Fox J, Fidler S, Phillips R, Frater J; SPARTAC and CHERUB Investigators.

PLoS Pathog. 2016 Jul 14;12(7):e1005661. doi: 10.1371/journal.ppat.1005661. eCollection 2016 Jul.

6.

Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression.

Clayton KL, Douglas-Vail MB, Nur-ur Rahman AK, Medcalf KE, Xie IY, Chew GM, Tandon R, Lanteri MC, Norris PJ, Deeks SG, Ndhlovu LC, Ostrowski MA.

J Virol. 2015 Apr;89(7):3723-36. doi: 10.1128/JVI.00006-15. Epub 2015 Jan 21.

7.

Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques.

Fujita T, Burwitz BJ, Chew GM, Reed JS, Pathak R, Seger E, Clayton KL, Rini JM, Ostrowski MA, Ishii N, Kuroda MJ, Hansen SG, Sacha JB, Ndhlovu LC.

J Immunol. 2014 Dec 1;193(11):5576-83. doi: 10.4049/jimmunol.1400961. Epub 2014 Oct 27.

8.

PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia.

Tendeiro R, Foxall RB, Baptista AP, Pinto F, Soares RS, Cavaleiro R, Valadas E, Gomes P, Victorino RM, Sousa AE.

AIDS. 2012 Jun 1;26(9):1065-71. doi: 10.1097/QAD.0b013e32835374db.

PMID:
22441249
9.

Tim-3 blocking rescue macrophage and T cell function against Mycobacterium tuberculosis infection in HIV+ patients.

Sada-Ovalle I, Ocaña-Guzman R, Pérez-Patrigeón S, Chávez-Galán L, Sierra-Madero J, Torre-Bouscoulet L, Addo MM.

J Int AIDS Soc. 2015 Oct 19;18:20078. doi: 10.7448/IAS.18.1.20078. eCollection 2015.

10.

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.

Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, Long BR, Wong JC, Satkunarajah M, Schweneker M, Chapman JM, Gyenes G, Vali B, Hyrcza MD, Yue FY, Kovacs C, Sassi A, Loutfy M, Halpenny R, Persad D, Spotts G, Hecht FM, Chun TW, McCune JM, Kaul R, Rini JM, Nixon DF, Ostrowski MA.

J Exp Med. 2008 Nov 24;205(12):2763-79. doi: 10.1084/jem.20081398. Epub 2008 Nov 10.

11.

Detectable viral load aggravates immunosenescence features of CD8 T-cell subsets in vertically HIV-infected children.

Díaz L, Méndez-Lagares G, Correa-Rocha R, Pacheco YM, Ferrando-Martínez S, Ruiz-Mateos E, del Mar del Pozo-Balado M, León JA, Gurbindo MD, Isabel de José M, Leal M, Muñoz-Fernández MÁ.

J Acquir Immune Defic Syndr. 2012 Aug 15;60(5):447-54.

PMID:
22549383
12.

Specific patterns of CD4-associated immunosenescence in vertically HIV-infected subjects.

Méndez-Lagares G, Díaz L, Correa-Rocha R, León Leal JA, Ferrando-Martínez S, Ruiz-Mateos E, Pozo-Balado MM, Gurbindo MD, de José MI, Muñoz-Fernández MA, Leal M, Pacheco YM.

Clin Microbiol Infect. 2013 Jun;19(6):558-65. doi: 10.1111/j.1469-0691.2012.03934.x. Epub 2012 Jun 27.

13.

Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells.

Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, McMahon BJ, Castelblanco N, Kuchroo V, Gretch DR, Rosen HR.

J Virol. 2009 Sep;83(18):9122-30. doi: 10.1128/JVI.00639-09. Epub 2009 Jul 8.

14.

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.

Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, Araki K, Freeman GJ, Kuchroo VK, Ahmed R.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14733-8. doi: 10.1073/pnas.1009731107. Epub 2010 Aug 2.

15.

Levels of CD56+TIM-3- effector CD8 T cells distinguish HIV natural virus suppressors from patients receiving antiretroviral therapy.

Poonia B, Pauza CD.

PLoS One. 2014 Feb 10;9(2):e88884. doi: 10.1371/journal.pone.0088884. eCollection 2014.

16.

Elevation of Tim-3 and PD-1 expression on T cells appears early in HIV infection, and differential Tim-3 and PD-1 expression patterns can be induced by common γ -chain cytokines.

Zhang ZN, Zhu ML, Chen YH, Fu YJ, Zhang TW, Jiang YJ, Chu ZX, Shang H.

Biomed Res Int. 2015;2015:916936. doi: 10.1155/2015/916936. Epub 2015 Jan 22.

17.

Characterization of age-associated exhausted CD8⁺ T cells defined by increased expression of Tim-3 and PD-1.

Lee KA, Shin KS, Kim GY, Song YC, Bae EA, Kim IK, Koh CH, Kang CY.

Aging Cell. 2016 Apr;15(2):291-300. doi: 10.1111/acel.12435. Epub 2016 Jan 10.

18.

Revisiting immune exhaustion during HIV infection.

Khaitan A, Unutmaz D.

Curr HIV/AIDS Rep. 2011 Mar;8(1):4-11. doi: 10.1007/s11904-010-0066-0. Review.

19.

The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults.

Sainz T, Serrano-Villar S, Díaz L, González Tomé MI, Gurbindo MD, de José MI, Mellado MJ, Ramos JT, Zamora J, Moreno S, Muñoz-Fernández MA.

AIDS. 2013 Jun 1;27(9):1513-6. doi: 10.1097/QAD.0b013e32835faa72.

PMID:
23435292
20.

Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection.

Elahi S, Niki T, Hirashima M, Horton H.

Blood. 2012 May 3;119(18):4192-204. doi: 10.1182/blood-2011-11-389585. Epub 2012 Mar 21.

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