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Items: 1 to 20 of 104


The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche.

Zou Y, Niu W, Qin S, Downes M, Burns DK, Zhang CL.

Mol Cell Biol. 2012 Dec;32(23):4811-20. doi: 10.1128/MCB.01122-12. Epub 2012 Oct 1.


The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation.

Liu HK, Wang Y, Belz T, Bock D, Takacs A, Radlwimmer B, Barbus S, Reifenberger G, Lichter P, Schütz G.

Genes Dev. 2010 Apr 1;24(7):683-95. doi: 10.1101/gad.560310.


The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells.

Park HJ, Kim JK, Jeon HM, Oh SY, Kim SH, Nam DH, Kim H.

Mol Cells. 2010 Nov;30(5):403-8. doi: 10.1007/s10059-010-0122-z. Epub 2010 Aug 31. Erratum in: Mol Cells. 2011 Feb ;31(2):199. Park, Myung-Jin [removed]; Soeda, Akio [removed].


Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes.

Wu D, Yu S, Jia L, Zou C, Xu Z, Xiao L, Wong KB, Ng CF, Chan FL.

J Pathol. 2015 May;236(1):103-15. doi: 10.1002/path.4505. Epub 2015 Feb 2.


Activation of postnatal neural stem cells requires nuclear receptor TLX.

Niu W, Zou Y, Shen C, Zhang CL.

J Neurosci. 2011 Sep 28;31(39):13816-28. doi: 10.1523/JNEUROSCI.1038-11.2011.


Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation.

Sun G, Yu RT, Evans RM, Shi Y.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15282-7. Epub 2007 Sep 14.


p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.

Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA.

Nature. 2008 Oct 23;455(7216):1129-33. doi: 10.1038/nature07443.


The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.

Murai K, Sun G, Ye P, Tian E, Yang S, Cui Q, Sun G, Trinh D, Sun O, Hong T, Wen Z, Kalkum M, Riggs AD, Song H, Ming GL, Shi Y.

Nat Commun. 2016 Mar 11;7:10965. doi: 10.1038/ncomms10965.


Histone demethylase LSD1 regulates neural stem cell proliferation.

Sun G, Alzayady K, Stewart R, Ye P, Yang S, Li W, Shi Y.

Mol Cell Biol. 2010 Apr;30(8):1997-2005. doi: 10.1128/MCB.01116-09. Epub 2010 Feb 1.


MicroRNA-378 regulates neural stem cell proliferation and differentiation in vitro by modulating Tailless expression.

Huang Y, Liu X, Wang Y.

Biochem Biophys Res Commun. 2015 Oct 16;466(2):214-20. doi: 10.1016/j.bbrc.2015.09.011. Epub 2015 Sep 7.


Gliomagenesis arising from Pten- and Ink4a/Arf-deficient neural progenitor cells is mediated by the p53-Fbxw7/Cdc4 pathway, which controls c-Myc.

Kim HS, Woolard K, Lai C, Bauer PO, Maric D, Song H, Li A, Kotliarova S, Zhang W, Fine HA.

Cancer Res. 2012 Nov 15;72(22):6065-75. doi: 10.1158/0008-5472.CAN-12-2594. Epub 2012 Sep 17.


A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes.

Giachino C, Boulay JL, Ivanek R, Alvarado A, Tostado C, Lugert S, Tchorz J, Coban M, Mariani L, Bettler B, Lathia J, Frank S, Pfister S, Kool M, Taylor V.

Cancer Cell. 2015 Dec 14;28(6):730-42. doi: 10.1016/j.ccell.2015.10.008. Epub 2015 Dec 5.


Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal.

Qu Q, Sun G, Li W, Yang S, Ye P, Zhao C, Yu RT, Gage FH, Evans RM, Shi Y.

Nat Cell Biol. 2010 Jan;12(1):31-40; sup pp 1-9. doi: 10.1038/ncb2001. Epub 2009 Dec 13.


Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain.

Li W, Sun G, Yang S, Qu Q, Nakashima K, Shi Y.

Mol Endocrinol. 2008 Jan;22(1):56-64. Epub 2007 Sep 27.


MEF promotes stemness in the pathogenesis of gliomas.

Bazzoli E, Pulvirenti T, Oberstadt MC, Perna F, Wee B, Schultz N, Huse JT, Fomchenko EI, Voza F, Tabar V, Brennan CW, DeAngelis LM, Nimer SD, Holland EC, Squatrito M.

Cell Stem Cell. 2012 Dec 7;11(6):836-44. doi: 10.1016/j.stem.2012.09.012.


MicroRNA-146a inhibits glioma development by targeting Notch1.

Mei J, Bachoo R, Zhang CL.

Mol Cell Biol. 2011 Sep;31(17):3584-92. doi: 10.1128/MCB.05821-11. Epub 2011 Jul 5.


Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner.

Muñoz DM, Tung T, Agnihotri S, Singh S, Guha A, Zadeh G, Hawkins C.

Glia. 2013 Nov;61(11):1862-72. doi: 10.1002/glia.22563. Epub 2013 Aug 30.


Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21.

Dai B, Hu Z, Huang H, Zhu G, Xiao Z, Wan W, Zhang P, Jia W, Zhang L.

Biochem Biophys Res Commun. 2014 Nov 7;454(1):221-7. doi: 10.1016/j.bbrc.2014.10.078. Epub 2014 Oct 22.


Expression of Tlx in both stem cells and transit amplifying progenitors regulates stem cell activation and differentiation in the neonatal lateral subependymal zone.

Obernier K, Simeonova I, Fila T, Mandl C, Hölzl-Wenig G, Monaghan-Nichols P, Ciccolini F.

Stem Cells. 2011 Sep;29(9):1415-26. doi: 10.1002/stem.682.

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