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Items: 1 to 20 of 91

1.

Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease.

Rousseaux MW, Marcogliese PC, Qu D, Hewitt SJ, Seang S, Kim RH, Slack RS, Schlossmacher MG, Lagace DC, Mak TW, Park DS.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15918-23. Epub 2012 Sep 10. Erratum in: Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11212.

2.

Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra.

Corradini BR, Iamashita P, Tampellini E, Farfel JM, Grinberg LT, Moreira-Filho CA.

Biomed Res Int. 2014;2014:543673. doi: 10.1155/2014/543673. Epub 2014 Nov 26.

3.

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation.

Liu G, Yu J, Ding J, Xie C, Sun L, Rudenko I, Zheng W, Sastry N, Luo J, Rudow G, Troncoso JC, Cai H.

J Clin Invest. 2014 Jul;124(7):3032-46. doi: 10.1172/JCI72176. Epub 2014 May 27.

4.

Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms.

Perier C, Bender A, García-Arumí E, Melià MJ, Bové J, Laub C, Klopstock T, Elstner M, Mounsey RB, Teismann P, Prolla T, Andreu AL, Vila M.

Brain. 2013 Aug;136(Pt 8):2369-78. doi: 10.1093/brain/awt196.

PMID:
23884809
5.

Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease.

Korecka JA, Moloney EB, Eggers R, Hobo B, Scheffer S, Ras-Verloop N, Pasterkamp RJ, Swaab DF, Smit AB, van Kesteren RE, Bossers K, Verhaagen J.

J Neurosci. 2017 Sep 27;37(39):9361-9379. doi: 10.1523/JNEUROSCI.0084-17.2017. Epub 2017 Aug 21.

PMID:
28842419
6.

Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1(-/-) mice.

Nguyen TA, Frank-Cannon T, Martinez TN, Ruhn KA, Marvin M, Casey B, Treviño I, Hong JJ, Goldberg MS, Tansey MG.

J Neuroinflammation. 2013 Apr 28;10:50. doi: 10.1186/1742-2094-10-50.

7.

Thiol Oxidation by Diamide Leads to Dopaminergic Degeneration and Parkinsonism Phenotype in Mice: A Model for Parkinson's Disease.

Ray A, Kambali M, Ravindranath V.

Antioxid Redox Signal. 2016 Aug 10;25(5):252-67. doi: 10.1089/ars.2015.6602. Epub 2016 Jun 13.

PMID:
27121974
8.

Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease.

Sasaki M, Shibata E, Tohyama K, Takahashi J, Otsuka K, Tsuchiya K, Takahashi S, Ehara S, Terayama Y, Sakai A.

Neuroreport. 2006 Jul 31;17(11):1215-8.

PMID:
16837857
9.

Transduced Tat-DJ-1 protein protects against oxidative stress-induced SH-SY5Y cell death and Parkinson disease in a mouse model.

Jeong HJ, Kim DW, Woo SJ, Kim HR, Kim SM, Jo HS, Park M, Kim DS, Kwon OS, Hwang IK, Han KH, Park J, Eum WS, Choi SY.

Mol Cells. 2012 May;33(5):471-8. doi: 10.1007/s10059-012-2255-8. Epub 2012 Apr 17.

10.

Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice.

Kitada T, Tong Y, Gautier CA, Shen J.

J Neurochem. 2009 Nov;111(3):696-702. doi: 10.1111/j.1471-4159.2009.06350.x. Epub 2009 Aug 19.

11.

Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease.

Branch SY, Chen C, Sharma R, Lechleiter JD, Li S, Beckstead MJ.

J Neurosci. 2016 Apr 6;36(14):4026-37. doi: 10.1523/JNEUROSCI.1395-15.2016.

12.

DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease.

Takahashi-Niki K, Inafune A, Michitani N, Hatakeyama Y, Suzuki K, Sasaki M, Kitamura Y, Niki T, Iguchi-Ariga SM, Ariga H.

J Pharmacol Sci. 2015 Mar;127(3):305-10. doi: 10.1016/j.jphs.2015.01.010. Epub 2015 Feb 20.

13.

LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila.

Marcogliese PC, Abuaish S, Kabbach G, Abdel-Messih E, Seang S, Li G, Slack RS, Haque ME, Venderova K, Park DS.

Hum Mol Genet. 2017 Apr 1;26(7):1247-1257. doi: 10.1093/hmg/ddx030.

PMID:
28158614
14.

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice.

Zhang J, Götz S, Vogt Weisenhorn DM, Simeone A, Wurst W, Prakash N.

Neurobiol Dis. 2015 Oct;82:32-45. doi: 10.1016/j.nbd.2015.05.015. Epub 2015 Jun 3.

PMID:
26049140
15.

Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.

Lu XH, Fleming SM, Meurers B, Ackerson LC, Mortazavi F, Lo V, Hernandez D, Sulzer D, Jackson GR, Maidment NT, Chesselet MF, Yang XW.

J Neurosci. 2009 Feb 18;29(7):1962-76. doi: 10.1523/JNEUROSCI.5351-08.2009.

16.

Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson's disease.

Sugama S, Sekiyama K, Kodama T, Takamatsu Y, Takenouchi T, Hashimoto M, Bruno C, Kakinuma Y.

Brain Behav Immun. 2016 Jan;51:39-46. doi: 10.1016/j.bbi.2015.08.015. Epub 2015 Aug 17.

17.

The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease.

Ghosh A, Saminathan H, Kanthasamy A, Anantharam V, Jin H, Sondarva G, Harischandra DS, Qian Z, Rana A, Kanthasamy AG.

J Biol Chem. 2013 Jul 26;288(30):21955-71. doi: 10.1074/jbc.M112.444224. Epub 2013 Jun 10.

18.

Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease.

Barzilai A, Melamed E.

Trends Mol Med. 2003 Mar;9(3):126-32. Review.

PMID:
12657434
19.

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.

Recasens A, Dehay B, Bové J, Carballo-Carbajal I, Dovero S, Pérez-Villalba A, Fernagut PO, Blesa J, Parent A, Perier C, Fariñas I, Obeso JA, Bezard E, Vila M.

Ann Neurol. 2014 Mar;75(3):351-62. doi: 10.1002/ana.24066. Epub 2014 Feb 18.

PMID:
24243558
20.

Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of dopaminergic neurons during Parkinson's disease.

González H, Contreras F, Prado C, Elgueta D, Franz D, Bernales S, Pacheco R.

J Immunol. 2013 May 15;190(10):5048-56. doi: 10.4049/jimmunol.1203121. Epub 2013 Apr 15.

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