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Items: 1 to 20 of 90

1.

Targeting the TGFβ signalling pathway in disease.

Akhurst RJ, Hata A.

Nat Rev Drug Discov. 2012 Oct;11(10):790-811. doi: 10.1038/nrd3810. Epub 2012 Sep 24. Review.

2.

Targeting the TGFβ pathway for cancer therapy.

Neuzillet C, Tijeras-Raballand A, Cohen R, Cros J, Faivre S, Raymond E, de Gramont A.

Pharmacol Ther. 2015 Mar;147:22-31. doi: 10.1016/j.pharmthera.2014.11.001. Epub 2014 Nov 6. Review.

3.

Large- and small-molecule inhibitors of transforming growth factor-beta signaling.

Akhurst RJ.

Curr Opin Investig Drugs. 2006 Jun;7(6):513-21. Review.

PMID:
16784021
4.

The TGFBeta pathway as a therapeutic target in cancer.

Seoane J.

Clin Transl Oncol. 2008 Jan;10(1):14-9. Review.

PMID:
18208788
5.

Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling.

Beyer C, Zenzmaier C, Palumbo-Zerr K, Mancuso R, Distler A, Dees C, Zerr P, Huang J, Maier C, Pachowsky ML, Friebe A, Sandner P, Distler O, Schett G, Berger P, Distler JH.

Ann Rheum Dis. 2015 Jul;74(7):1408-16. doi: 10.1136/annrheumdis-2013-204508. Epub 2014 Feb 23.

PMID:
24567525
6.

Targeting TGFbeta-mediated processes in cancer.

Romano MF.

Curr Opin Drug Discov Devel. 2009 Mar;12(2):253-63. Review.

PMID:
19333871
7.

TGF beta inhibition for cancer therapy.

Saunier EF, Akhurst RJ.

Curr Cancer Drug Targets. 2006 Nov;6(7):565-78. Review.

PMID:
17100564
8.

Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts.

Mori Y, Ishida W, Bhattacharyya S, Li Y, Platanias LC, Varga J.

Arthritis Rheum. 2004 Dec;50(12):4008-21.

9.

Transforming the TGFbeta pathway: convergence of distinct lead generation strategies on a novel kinase pharmacophore for TbetaRI (ALK5).

Singh J, Ling LE, Sawyer JS, Lee WC, Zhang F, Yingling JM.

Curr Opin Drug Discov Devel. 2004 Jul;7(4):437-45. Review.

PMID:
15338953
10.

Inhibition of TGFβ signaling and its implications in anticancer treatments.

Calone I, Souchelnytskyi S.

Exp Oncol. 2012;34(1):9-16. Review.

PMID:
22453142
11.

Selective inhibitors of type I receptor kinase block cellular transforming growth factor-beta signaling.

Ge R, Rajeev V, Subramanian G, Reiss KA, Liu D, Higgins L, Joly A, Dugar S, Chakravarty J, Henson M, McEnroe G, Schreiner G, Reiss M.

Biochem Pharmacol. 2004 Jul 1;68(1):41-50.

PMID:
15183116
12.
13.

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.

Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA Jr, Wrana JL, Falb D.

Cell. 1997 Jun 27;89(7):1165-73.

14.

TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.

Liu IM, Schilling SH, Knouse KA, Choy L, Derynck R, Wang XF.

EMBO J. 2009 Jan 21;28(2):88-98. doi: 10.1038/emboj.2008.266. Epub 2008 Dec 18.

15.

MicroRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway.

Tu X, Zhang H, Zhang J, Zhao S, Zheng X, Zhang Z, Zhu J, Chen J, Dong L, Zang Y, Zhang J.

J Pathol. 2014 Sep;234(1):46-59. doi: 10.1002/path.4373. Epub 2014 Jun 17.

PMID:
24817606
16.

Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness.

Gaspar NJ, Li L, Kapoun AM, Medicherla S, Reddy M, Li G, O'Young G, Quon D, Henson M, Damm DL, Muiru GT, Murphy A, Higgins LS, Chakravarty S, Wong DH.

Mol Pharmacol. 2007 Jul;72(1):152-61. Epub 2007 Mar 30.

17.

Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway.

de Figueiredo-Pontes LL, Assis PA, Santana-Lemos BA, Jácomo RH, Lima AS, Garcia AB, Thomé CH, Araújo AG, Panepucci RA, Zago MA, Nagler A, Falcão RP, Rego EM.

PLoS One. 2011;6(10):e26713. doi: 10.1371/journal.pone.0026713. Epub 2011 Oct 28.

18.

Tgf-beta type I receptor (Alk5) kinase inhibitors in oncology.

Ling LE, Lee WC.

Curr Pharm Biotechnol. 2011 Dec;12(12):2190-202. Review.

PMID:
21619541
19.

TGFbeta, cardiac fibroblasts, and the fibrotic response.

Leask A.

Cardiovasc Res. 2007 May 1;74(2):207-12. Epub 2006 Jul 21. Review.

PMID:
16919613
20.

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