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Items: 1 to 20 of 102

1.

Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment.

Xu S, Butkevich AN, Yamada R, Zhou Y, Debnath B, Duncan R, Zandi E, Petasis NA, Neamati N.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16348-53. doi: 10.1073/pnas.1205226109. Epub 2012 Sep 17.

2.

Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase.

Ge J, Zhang CJ, Li L, Chong LM, Wu X, Hao P, Sze SK, Yao SQ.

ACS Chem Biol. 2013 Nov 15;8(11):2577-85. doi: 10.1021/cb4002602. Epub 2013 Sep 26.

PMID:
24070012
3.
4.

Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase.

Carbone DL, Doorn JA, Kiebler Z, Petersen DR.

Chem Res Toxicol. 2005 Aug;18(8):1324-31.

PMID:
16097806
5.
6.
7.

Peptide binding to protein disulfide isomerase occurs at a site distinct from the active sites.

Noiva R, Freedman RB, Lennarz WJ.

J Biol Chem. 1993 Sep 15;268(26):19210-7.

8.

Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma.

Vatolin S, Phillips JG, Jha BK, Govindgari S, Hu J, Grabowski D, Parker Y, Lindner DJ, Zhong F, Distelhorst CW, Smith MR, Cotta C, Xu Y, Chilakala S, Kuang RR, Tall S, Reu FJ.

Cancer Res. 2016 Jun 1;76(11):3340-50. doi: 10.1158/0008-5472.CAN-15-3099. Epub 2016 Apr 6.

9.

Bacitracin inhibits the reductive activity of protein disulfide isomerase by disulfide bond formation with free cysteines in the substrate-binding domain.

Dickerhof N, Kleffmann T, Jack R, McCormick S.

FEBS J. 2011 Jun;278(12):2034-43. doi: 10.1111/j.1742-4658.2011.08119.x. Epub 2011 May 17.

10.

Protein disulfide isomerase: a promising target for cancer therapy.

Xu S, Sankar S, Neamati N.

Drug Discov Today. 2014 Mar;19(3):222-40. doi: 10.1016/j.drudis.2013.10.017. Epub 2013 Oct 31. Review.

PMID:
24184531
11.

Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs).

Yamada R, Cao X, Butkevich AN, Millard M, Odde S, Mordwinkin N, Gundla R, Zandi E, Louie SG, Petasis NA, Neamati N.

J Med Chem. 2011 Apr 28;54(8):2902-14. doi: 10.1021/jm101655d. Epub 2011 Mar 28.

PMID:
21443194
12.

Zinc-dependent dimerization of the folding catalyst, protein disulfide isomerase.

Solovyov A, Gilbert HF.

Protein Sci. 2004 Jul;13(7):1902-7. Epub 2004 May 28.

13.

Catalytic activity and chaperone function of human protein-disulfide isomerase are required for the efficient refolding of proinsulin.

Winter J, Klappa P, Freedman RB, Lilie H, Rudolph R.

J Biol Chem. 2002 Jan 4;277(1):310-7. Epub 2001 Nov 1.

14.

Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells.

Janiszewski M, Lopes LR, Carmo AO, Pedro MA, Brandes RP, Santos CX, Laurindo FR.

J Biol Chem. 2005 Dec 9;280(49):40813-9. Epub 2005 Sep 8.

15.

A 21-kDa C-terminal fragment of protein-disulfide isomerase has isomerase, chaperone, and anti-chaperone activities.

Puig A, Primm TP, Surendran R, Lee JC, Ballard KD, Orkiszewski RS, Makarov V, Gilbert HF.

J Biol Chem. 1997 Dec 26;272(52):32988-94.

16.

Modulation of an active-site cysteine pKa allows PDI to act as a catalyst of both disulfide bond formation and isomerization.

Karala AR, Lappi AK, Ruddock LW.

J Mol Biol. 2010 Mar 5;396(4):883-92. doi: 10.1016/j.jmb.2009.12.014. Epub 2009 Dec 21.

PMID:
20026073
17.

Gene sequencing, modelling and immunolocalization of the protein disulfide isomerase from Plasmodium chabaudi.

Novo C, Martins TM, Prata S, Lopes A, Armada A.

Int J Biol Macromol. 2009 Nov 1;45(4):399-406. doi: 10.1016/j.ijbiomac.2009.07.001. Epub 2009 Jul 15.

PMID:
19615402
19.

Nitroxide 4-hydroxy-2,2',6,6'-tetramethylpiperidine 1-oxyl (Tempol) inhibits the reductase activity of protein disulfide isomerase via covalent binding to the Cys400 residue on CXXC redox motif at the a'active site.

Santos GB, Gonzalez-Perilli L, Mastrogiovanni M, Aicardo A, Cerdeira CD, Trostchansky A, Brigag√£o MRPL.

Chem Biol Interact. 2017 Jun 25;272:117-124. doi: 10.1016/j.cbi.2017.05.015. Epub 2017 May 19.

PMID:
28532685
20.

Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response.

Townsend DM, Manevich Y, He L, Xiong Y, Bowers RR Jr, Hutchens S, Tew KD.

Cancer Res. 2009 Oct 1;69(19):7626-34. doi: 10.1158/0008-5472.CAN-09-0493. Epub 2009 Sep 22.

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