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Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and Toll-like receptors in the adult prefrontal cortex.

Vetreno RP, Crews FT.

Neuroscience. 2012 Dec 13;226:475-88. doi: 10.1016/j.neuroscience.2012.08.046. Epub 2012 Sep 15.


Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking.

Vetreno RP, Qin L, Crews FT.

Neurobiol Dis. 2013 Nov;59:52-62. doi: 10.1016/j.nbd.2013.07.002. Epub 2013 Jul 15.


High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence.

Crews FT, Qin L, Sheedy D, Vetreno RP, Zou J.

Biol Psychiatry. 2013 Apr 1;73(7):602-12. doi: 10.1016/j.biopsych.2012.09.030. Epub 2012 Dec 1.


Oleoylethanolamide prevents neuroimmune HMGB1/TLR4/NF-kB danger signaling in rat frontal cortex and depressive-like behavior induced by ethanol binge administration.

Antón M, Alén F, Gómez de Heras R, Serrano A, Pavón FJ, Leza JC, García-Bueno B, Rodríguez de Fonseca F, Orio L.

Addict Biol. 2017 May;22(3):724-741. doi: 10.1111/adb.12365. Epub 2016 Feb 9.


Involvement of TLR4 in the long-term epigenetic changes, rewarding and anxiety effects induced by intermittent ethanol treatment in adolescence.

Montesinos J, Pascual M, Rodríguez-Arias M, Miñarro J, Guerri C.

Brain Behav Immun. 2016 Mar;53:159-171. doi: 10.1016/j.bbi.2015.12.006. Epub 2015 Dec 10.


Neuroimmune activation and myelin changes in adolescent rats exposed to high-dose alcohol and associated cognitive dysfunction: a review with reference to human adolescent drinking.

Pascual M, Pla A, Miñarro J, Guerri C.

Alcohol Alcohol. 2014 Mar-Apr;49(2):187-92. doi: 10.1093/alcalc/agt164. Epub 2013 Nov 10. Review.


Mechanisms of neuroimmune gene induction in alcoholism.

Crews FT, Vetreno RP.

Psychopharmacology (Berl). 2016 May;233(9):1543-57. doi: 10.1007/s00213-015-3906-1. Epub 2015 Mar 20. Review.


Adolescent intermittent ethanol exposure enhances ethanol activation of the nucleus accumbens while blunting the prefrontal cortex responses in adult rat.

Liu W, Crews FT.

Neuroscience. 2015 May 7;293:92-108. doi: 10.1016/j.neuroscience.2015.02.014. Epub 2015 Feb 26.


Adolescent, but not adult, binge ethanol exposure leads to persistent global reductions of choline acetyltransferase expressing neurons in brain.

Vetreno RP, Broadwater M, Liu W, Spear LP, Crews FT.

PLoS One. 2014 Nov 18;9(11):e113421. doi: 10.1371/journal.pone.0113421. eCollection 2014.


Alcohol binge drinking during adolescence or dependence during adulthood reduces prefrontal myelin in male rats.

Vargas WM, Bengston L, Gilpin NW, Whitcomb BW, Richardson HN.

J Neurosci. 2014 Oct 29;34(44):14777-82. doi: 10.1523/JNEUROSCI.3189-13.2014.


Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice.

Coleman LG Jr, He J, Lee J, Styner M, Crews FT.

Alcohol Clin Exp Res. 2011 Apr;35(4):671-88. doi: 10.1111/j.1530-0277.2010.01385.x. Epub 2011 Jan 11.


Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood.

Gass JT, Glen WB Jr, McGonigal JT, Trantham-Davidson H, Lopez MF, Randall PK, Yaxley R, Floresco SB, Chandler LJ.

Neuropsychopharmacology. 2014 Oct;39(11):2570-83. doi: 10.1038/npp.2014.109. Epub 2014 May 13.


ADX-47273, a mGlu5 receptor positive allosteric modulator, attenuates deficits in cognitive flexibility induced by withdrawal from 'binge-like' ethanol exposure in rats.

Marszalek-Grabska M, Gibula-Bruzda E, Bodzon-Kulakowska A, Suder P, Gawel K, Talarek S, Listos J, Kedzierska E, Danysz W, Kotlinska JH.

Behav Brain Res. 2018 Feb 15;338:9-16. doi: 10.1016/j.bbr.2017.10.007. Epub 2017 Oct 10.


Adolescent binge ethanol treatment alters adult brain regional volumes, cortical extracellular matrix protein and behavioral flexibility.

Coleman LG Jr, Liu W, Oguz I, Styner M, Crews FT.

Pharmacol Biochem Behav. 2014 Jan;116:142-51. doi: 10.1016/j.pbb.2013.11.021. Epub 2013 Nov 23.


Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment.

Vetreno RP, Yaxley R, Paniagua B, Johnson GA, Crews FT.

Addict Biol. 2017 May;22(3):712-723. doi: 10.1111/adb.12364. Epub 2016 Feb 1.


TLR4 elimination prevents synaptic and myelin alterations and long-term cognitive dysfunctions in adolescent mice with intermittent ethanol treatment.

Montesinos J, Pascual M, Pla A, Maldonado C, Rodríguez-Arias M, Miñarro J, Guerri C.

Brain Behav Immun. 2015 Mar;45:233-44. doi: 10.1016/j.bbi.2014.11.015. Epub 2014 Dec 5.


Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration.

Qin L, Crews FT.

J Neuroinflammation. 2012 Jun 18;9:130. doi: 10.1186/1742-2094-9-130.


Toll-like receptor signaling and stages of addiction.

Crews FT, Walter TJ, Coleman LG Jr, Vetreno RP.

Psychopharmacology (Berl). 2017 May;234(9-10):1483-1498. doi: 10.1007/s00213-017-4560-6. Epub 2017 Feb 17. Review.


Activated microglia are implicated in cognitive deficits, neuronal death, and successful recovery following intermittent ethanol exposure.

Zhao YN, Wang F, Fan YX, Ping GF, Yang JY, Wu CF.

Behav Brain Res. 2013 Jan 1;236(1):270-82. doi: 10.1016/j.bbr.2012.08.052. Epub 2012 Sep 5.


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