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Items: 1 to 20 of 84

1.

Enhancement of gene silencing effect and membrane permeability by Peptide-conjugated 27-nucleotide small interfering RNA.

Kubo T, Yanagihara K, Sato Y, Morita Y, Seyama T.

Molecules. 2012 Sep 14;17(9):11089-102. doi: 10.3390/molecules170911089.

2.

Amino-modified and lipid-conjugated dicer-substrate siRNA enhances RNAi efficacy.

Kubo T, Takei Y, Mihara K, Yanagihara K, Seyama T.

Bioconjug Chem. 2012 Feb 15;23(2):164-73. doi: 10.1021/bc200333w. Epub 2012 Jan 26.

PMID:
22236254
3.

Palmitic acid-conjugated 21-nucleotide siRNA enhances gene-silencing activity.

Kubo T, Yanagihara K, Takei Y, Mihara K, Morita Y, Seyama T.

Mol Pharm. 2011 Dec 5;8(6):2193-203. doi: 10.1021/mp200250f. Epub 2011 Oct 24.

PMID:
21985606
4.

Gene-silencing potency of symmetric and asymmetric lipid-conjugated siRNAs and its correlation with dicer recognition.

Kubo T, Yanagihara K, Sato Y, Nishimura Y, Kondo S, Seyama T.

Bioconjug Chem. 2013 Dec 18;24(12):2045-57. doi: 10.1021/bc400391n. Epub 2013 Dec 9.

PMID:
24274056
5.

SiRNAs conjugated with aromatic compounds induce RISC-mediated antisense strand selection and strong gene-silencing activity.

Kubo T, Yanagihara K, Takei Y, Mihara K, Sato Y, Seyama T.

Biochem Biophys Res Commun. 2012 Oct 5;426(4):571-7. doi: 10.1016/j.bbrc.2012.08.128. Epub 2012 Sep 7.

PMID:
22982308
6.

Lipid-conjugated 27-nucleotide double-stranded RNAs with dicer-substrate potency enhance RNAi-mediated gene silencing.

Kubo T, Yanagihara K, Takei Y, Mihara K, Sato Y, Seyama T.

Mol Pharm. 2012 May 7;9(5):1374-83. doi: 10.1021/mp2006278. Epub 2012 Apr 24.

PMID:
22494497
7.

Potent RNAi by short RNA triggers.

Chu CY, Rana TM.

RNA. 2008 Sep;14(9):1714-9. doi: 10.1261/rna.1161908. Epub 2008 Jul 24.

8.

Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells.

Chiu YL, Ali A, Chu CY, Cao H, Rana TM.

Chem Biol. 2004 Aug;11(8):1165-75.

9.

Phosphorylatable short peptide conjugated low molecular weight chitosan for efficient siRNA delivery and target gene silencing.

Kong F, Liu G, Sun B, Zhou S, Zuo A, Zhao R, Liang D.

Int J Pharm. 2012 Jan 17;422(1-2):445-53. doi: 10.1016/j.ijpharm.2011.10.041. Epub 2011 Oct 28.

PMID:
22067703
10.

Modified 27-nt dsRNAs with dramatically enhanced stability in serum and long-term RNAi activity.

Kubo T, Zhelev Z, Ohba H, Bakalova R.

Oligonucleotides. 2007 Winter;17(4):445-64.

PMID:
17894530
11.
12.

Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection.

Sano M, Sierant M, Miyagishi M, Nakanishi M, Takagi Y, Sutou S.

Nucleic Acids Res. 2008 Oct;36(18):5812-21. doi: 10.1093/nar/gkn584. Epub 2008 Sep 9.

13.

Rational design and in vitro and in vivo delivery of Dicer substrate siRNA.

Amarzguioui M, Lundberg P, Cantin E, Hagstrom J, Behlke MA, Rossi JJ.

Nat Protoc. 2006;1(2):508-17.

PMID:
17406276
14.

Competition potency of siRNA is specified by the 5'-half sequence of the guide strand.

Yoo JW, Kim S, Lee DK.

Biochem Biophys Res Commun. 2008 Feb 29;367(1):78-83. doi: 10.1016/j.bbrc.2007.12.099. Epub 2007 Dec 27.

PMID:
18164261
15.

Dicer-labile PEG conjugates for siRNA delivery.

Kow SC, McCarroll J, Valade D, Boyer C, Dwarte T, Davis TP, Kavallaris M, Bulmus V.

Biomacromolecules. 2011 Dec 12;12(12):4301-10. doi: 10.1021/bm201199c. Epub 2011 Nov 21.

PMID:
22053777
16.

Effect of nanoparticle conjugation on gene silencing by RNA interference.

Singh N, Agrawal A, Leung AK, Sharp PA, Bhatia SN.

J Am Chem Soc. 2010 Jun 23;132(24):8241-3. doi: 10.1021/ja102132e.

17.

Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates.

Vengut-Climent E, Terrazas M, Lucas R, Arévalo-Ruiz M, Eritja R, Morales JC.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4048-51. doi: 10.1016/j.bmcl.2013.05.065. Epub 2013 May 28.

PMID:
23764303
18.

Development of peptide-oligonucleotide conjugates for regulation of small RNA function.

Yamayoshi A, Momokawa D, Kobori A, Murakami A.

Nucleic Acids Symp Ser (Oxf). 2009;(53):53-4. doi: 10.1093/nass/nrp027.

PMID:
19749256
19.

RNA interference: the molecular immune system.

Bagasra O, Prilliman KR.

J Mol Histol. 2004 Aug;35(6):545-53. Review.

PMID:
15614608
20.

The design, selection, and evaluation of highly specific and functional siRNA incorporating unlocked nucleobase analogs.

Vaish N, Agarwal P.

Methods Mol Biol. 2013;942:111-34. doi: 10.1007/978-1-62703-119-6_6.

PMID:
23027048

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