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Items: 1 to 20 of 144

1.

Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates.

Radić Z, Sit RK, Garcia E, Zhang L, Berend S, Kovarik Z, Amitai G, Fokin VV, Barry Sharpless K, Taylor P.

Chem Biol Interact. 2013 Mar 25;203(1):67-71. doi: 10.1016/j.cbi.2012.08.014. Epub 2012 Sep 4.

2.

Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.

Kovarik Z, Maček N, Sit RK, Radić Z, Fokin VV, Barry Sharpless K, Taylor P.

Chem Biol Interact. 2013 Mar 25;203(1):77-80. doi: 10.1016/j.cbi.2012.08.019. Epub 2012 Sep 7.

3.

Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.

Radić Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2012 Apr 6;287(15):11798-809. doi: 10.1074/jbc.M111.333732. Epub 2012 Feb 16. Erratum in: J Biol Chem. 2012 Jun 1;287(23):19337.

4.

Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes.

Worek F, Wille T, Koller M, Thiermann H.

Chem Biol Interact. 2013 Mar 25;203(1):125-8. doi: 10.1016/j.cbi.2012.07.003. Epub 2012 Jul 22.

PMID:
22827894
5.

Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase.

Winter M, Wille T, Musilek K, Kuca K, Thiermann H, Worek F.

Toxicol Lett. 2016 Feb 26;244:136-42. doi: 10.1016/j.toxlet.2015.07.007. Epub 2015 Jul 22.

PMID:
26210933
6.

A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds.

Maxwell DM, Brecht KM, Sweeney RE.

Chem Biol Interact. 2013 Mar 25;203(1):72-6. doi: 10.1016/j.cbi.2012.08.024. Epub 2012 Sep 12.

PMID:
22982773
7.

Interactions between xylene-linked carbamoyl bis-pyridinium mono-oximes and organophosphates inhibited-AChE: a kinetic study.

Sharma R, Gupta B, Acharya J, Kaushik MP, Ghosh KK.

Toxicology. 2014 Feb 28;316:1-8. doi: 10.1016/j.tox.2013.11.011. Epub 2013 Dec 15.

PMID:
24345352
8.

New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.

Sit RK, Radić Z, Gerardi V, Zhang L, Garcia E, Katalinić M, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2011 Jun 3;286(22):19422-30. doi: 10.1074/jbc.M111.230656. Epub 2011 Apr 4.

9.

Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.

Renou J, Mercey G, Verdelet T, Păunescu E, Gillon E, Arboléas M, Loiodice M, Kliachyna M, Baati R, Nachon F, Jean L, Renard PY.

Chem Biol Interact. 2013 Mar 25;203(1):81-4. doi: 10.1016/j.cbi.2012.09.023. Epub 2012 Oct 27.

PMID:
23111374
10.

Synthesis and in vitro kinetic study of novel mono-pyridinium oximes as reactivators of organophosphorus (OP) inhibited human acetylcholinesterase (hAChE).

Valiveti AK, Bhalerao UM, Acharya J, Karade HN, Gundapu R, Halve AK, Kaushik MP.

Chem Biol Interact. 2015 Jul 25;237:125-32. doi: 10.1016/j.cbi.2015.06.007. Epub 2015 Jun 10.

PMID:
26070418
11.

Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor.

Rosenberg YJ, Mao L, Jiang X, Lees J, Zhang L, Radic Z, Taylor P.

Chem Biol Interact. 2017 Aug 25;274:50-57. doi: 10.1016/j.cbi.2017.07.003. Epub 2017 Jul 8.

PMID:
28693885
12.

In vitro reactivation of sarin-inhibited human acetylcholinesterase (AChE) by bis-pyridinium oximes connected by xylene linkers.

Acharya J, Dubey DK, Srivastava AK, Raza SK.

Toxicol In Vitro. 2011 Feb;25(1):251-6. doi: 10.1016/j.tiv.2010.07.024. Epub 2010 Aug 3.

PMID:
20688148
13.

Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase.

Worek F, von der Wellen J, Musilek K, Kuca K, Thiermann H.

Arch Toxicol. 2012 Sep;86(9):1379-86. doi: 10.1007/s00204-012-0842-2. Epub 2012 Mar 22.

PMID:
22437842
14.

In vitro investigation of efficacy of new reactivators on OPC inhibited rat brain acetylcholinesterase.

Atanasov VN, Petrova I, Dishovsky C.

Chem Biol Interact. 2013 Mar 25;203(1):139-43. doi: 10.1016/j.cbi.2012.11.020. Epub 2012 Dec 7.

PMID:
23220589
15.

Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates.

Chambers JE, Chambers HW, Meek EC, Pringle RB.

Chem Biol Interact. 2013 Mar 25;203(1):135-8. doi: 10.1016/j.cbi.2012.10.017. Epub 2012 Nov 2.

PMID:
23123249
16.

Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE).

Valiveti AK, Bhalerao UM, Acharya J, Karade HN, Acharya BN, Raviraju G, Halve AK, Kaushik MP.

Bioorg Med Chem. 2015 Aug 1;23(15):4899-910. doi: 10.1016/j.bmc.2015.05.027. Epub 2015 May 22.

PMID:
26043948
17.

Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds.

Wille T, Ekström F, Lee JC, Pang YP, Thiermann H, Worek F.

Biochem Pharmacol. 2010 Sep 15;80(6):941-6. doi: 10.1016/j.bcp.2010.05.022. Epub 2010 May 26.

PMID:
20510679
18.

Synthesis and in-vitro reactivation screening of imidazolium aldoximes as reactivators of sarin and VX-inhibited human acetylcholinesterase (hAChE).

Sharma R, Gupta B, Sahu AK, Acharya J, Satnami ML, Ghosh KK.

Chem Biol Interact. 2016 Nov 25;259(Pt B):85-92. doi: 10.1016/j.cbi.2016.04.034. Epub 2016 Apr 29.

PMID:
27138243
19.

Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE).

Karade HN, Raviraju G, Acharya BN, Valiveti AK, Bhalerao U, Acharya J.

Bioorg Med Chem. 2016 Sep 15;24(18):4171-4176. doi: 10.1016/j.bmc.2016.07.005. Epub 2016 Jul 6.

PMID:
27450532
20.

Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase.

Sahu AK, Sharma R, Gupta B, Musilek K, Kuca K, Acharya J, Ghosh KK.

Toxicol Mech Methods. 2016 Jun;26(5):319-26. doi: 10.3109/15376516.2016.1143070. Epub 2016 Apr 21.

PMID:
27101948

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