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The PARN deadenylase targets a discrete set of mRNAs for decay and regulates cell motility in mouse myoblasts.

Lee JE, Lee JY, Trembly J, Wilusz J, Tian B, Wilusz CJ.

PLoS Genet. 2012;8(8):e1002901. doi: 10.1371/journal.pgen.1002901. Epub 2012 Aug 30.


PolyA-specific ribonuclease (PARN-1) function in stage-specific mRNA turnover in Trypanosoma brucei.

Utter CJ, Garcia SA, Milone J, Bellofatto V.

Eukaryot Cell. 2011 Sep;10(9):1230-40. doi: 10.1128/EC.05097-11. Epub 2011 Jul 8.


Depletion of poly(A)-specific ribonuclease (PARN) inhibits proliferation of human gastric cancer cells by blocking cell cycle progression.

Zhang LN, Yan YB.

Biochim Biophys Acta. 2015 Feb;1853(2):522-34. doi: 10.1016/j.bbamcr.2014.12.004. Epub 2014 Dec 11.


Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells.

Lee JE, Lee JY, Wilusz J, Tian B, Wilusz CJ.

PLoS One. 2010 Jun 21;5(6):e11201. doi: 10.1371/journal.pone.0011201.


PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells.

Zhang X, Devany E, Murphy MR, Glazman G, Persaud M, Kleiman FE.

Nucleic Acids Res. 2015 Dec 15;43(22):10925-38. doi: 10.1093/nar/gkv959. Epub 2015 Sep 22.


Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment.

Clement SL, Scheckel C, Stoecklin G, Lykke-Andersen J.

Mol Cell Biol. 2011 Jan;31(2):256-66. doi: 10.1128/MCB.00717-10. Epub 2010 Nov 15.


Poly(A)-specific ribonuclease (PARN): an allosterically regulated, processive and mRNA cap-interacting deadenylase.

Virtanen A, Henriksson N, Nilsson P, Nissbeck M.

Crit Rev Biochem Mol Biol. 2013 Mar-Apr;48(2):192-209. doi: 10.3109/10409238.2013.771132. Epub 2013 Mar 15. Review.


A unique system for regulating mitochondrial mRNA poly(A) status and stability in plants.

Hirayama T.

Plant Signal Behav. 2014;9(10):e973809. doi: 10.4161/15592324.2014.973809.


Modulation of poly(A)-specific ribonuclease (PARN): current knowledge and perspectives.

Balatsos NA, Maragozidis P, Anastasakis D, Stathopoulos C.

Curr Med Chem. 2012;19(28):4838-49. Review.


Kiss your tail goodbye: the role of PARN, Nocturnin, and Angel deadenylases in mRNA biology.

Godwin AR, Kojima S, Green CB, Wilusz J.

Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):571-9. doi: 10.1016/j.bbagrm.2012.12.004. Epub 2012 Dec 26. Review.


Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action.

Brooks SA, Blackshear PJ.

Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):666-79. doi: 10.1016/j.bbagrm.2013.02.003. Epub 2013 Feb 18. Review.


Serum-deprivation stimulates cap-binding by PARN at the expense of eIF4E, consistent with the observed decrease in mRNA stability.

Seal R, Temperley R, Wilusz J, Lightowlers RN, Chrzanowska-Lightowlers ZM.

Nucleic Acids Res. 2005 Jan 14;33(1):376-87. Print 2005.


Coordinated expression of tristetraprolin post-transcriptionally attenuates mitogenic induction of the oncogenic Ser/Thr kinase Pim-1.

Mahat DB, Brennan-Laun SE, Fialcowitz-White EJ, Kishor A, Ross CR, Pozharskaya T, Rawn JD, Blackshear PJ, Hassel BA, Wilson GM.

PLoS One. 2012;7(3):e33194. doi: 10.1371/journal.pone.0033194. Epub 2012 Mar 8.


Identification of tristetraprolin as a factor that modulates the stability of the TAFI transcript through binding to the 3'-untranslated region.

Novakovic D, Kuo AC, Lin JH, Koschinsky ML, Boffa MB.

J Thromb Haemost. 2012 May;10(5):887-94. doi: 10.1111/j.1538-7836.2012.04689.x.


mRNA deadenylation by PARN is essential for embryogenesis in higher plants.

Reverdatto SV, Dutko JA, Chekanova JA, Hamilton DA, Belostotsky DA.

RNA. 2004 Aug;10(8):1200-14. Epub 2004 Jul 9.


CUG-BP binds to RNA substrates and recruits PARN deadenylase.

Moraes KC, Wilusz CJ, Wilusz J.

RNA. 2006 Jun;12(6):1084-91. Epub 2006 Apr 6.


Tristetraprolin regulates CXCL1 (KC) mRNA stability.

Datta S, Biswas R, Novotny M, Pavicic PG Jr, Herjan T, Mandal P, Hamilton TA.

J Immunol. 2008 Feb 15;180(4):2545-52.


Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU.

Tran H, Schilling M, Wirbelauer C, Hess D, Nagamine Y.

Mol Cell. 2004 Jan 16;13(1):101-11.


Genome-wide assessment of AU-rich elements by the AREScore algorithm.

Spasic M, Friedel CC, Schott J, Kreth J, Leppek K, Hofmann S, Ozgur S, Stoecklin G.

PLoS Genet. 2012 Jan;8(1):e1002433. doi: 10.1371/journal.pgen.1002433. Epub 2012 Jan 5.


The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins.

Krishnan N, Titus MA, Thapar R.

PLoS One. 2014 Jan 9;9(1):e85427. doi: 10.1371/journal.pone.0085427. eCollection 2014.

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