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Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.

Larson ET, Kim JE, Napuli AJ, Verlinde CL, Fan E, Zucker FH, Van Voorhis WC, Buckner FS, Hol WG, Merritt EA.

Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1194-200. doi: 10.1107/S0907444912024699. Epub 2012 Aug 18.


A dual-specificity aminoacyl-tRNA synthetase in the deep-rooted eukaryote Giardia lamblia.

Bunjun S, Stathopoulos C, Graham D, Min B, Kitabatake M, Wang AL, Wang CC, Vivarès CP, Weiss LM, Söll D.

Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):12997-3002.


Pre-transfer editing by class II prolyl-tRNA synthetase: role of aminoacylation active site in "selective release" of noncognate amino acids.

Hati S, Ziervogel B, Sternjohn J, Wong FC, Nagan MC, Rosen AE, Siliciano PG, Chihade JW, Musier-Forsyth K.

J Biol Chem. 2006 Sep 22;281(38):27862-72. Epub 2006 Jul 24.


Methanococcus jannaschii prolyl-cysteinyl-tRNA synthetase possesses overlapping amino acid binding sites.

Stathopoulos C, Jacquin-Becker C, Becker HD, Li T, Ambrogelly A, Longman R, Söll D.

Biochemistry. 2001 Jan 9;40(1):46-52.


The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs.

Arakaki TL, Carter M, Napuli AJ, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG, Merritt EA.

J Struct Biol. 2010 Aug;171(2):238-43. doi: 10.1016/j.jsb.2010.04.010. Epub 2010 May 8.


One polypeptide with two aminoacyl-tRNA synthetase activities.

Stathopoulos C, Li T, Longman R, Vothknecht UC, Becker HD, Ibba M, Söll D.

Science. 2000 Jan 21;287(5452):479-82.


The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases.

Kamtekar S, Kennedy WD, Wang J, Stathopoulos C, Söll D, Steitz TA.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1673-8. Epub 2003 Feb 10.


Synthesis of cysteinyl-tRNA(Cys) by a genome that lacks the normal cysteine-tRNA synthetase.

Lipman RS, Sowers KR, Hou YM.

Biochemistry. 2000 Jul 4;39(26):7792-8.


Cysteinyl-tRNA formation and prolyl-tRNA synthetase.

Jacquin-Becker C, Ahel I, Ambrogelly A, Ruan B, Söll D, Stathopoulos C.

FEBS Lett. 2002 Mar 6;514(1):34-6. Review.


Substrate specificity of bacterial prolyl-tRNA synthetase editing domain is controlled by a tunable hydrophobic pocket.

Kumar S, Das M, Hadad CM, Musier-Forsyth K.

J Biol Chem. 2012 Jan 27;287(5):3175-84. doi: 10.1074/jbc.M111.313619. Epub 2011 Nov 29.


Transfer RNA modulates the editing mechanism used by class II prolyl-tRNA synthetase.

Splan KE, Ignatov ME, Musier-Forsyth K.

J Biol Chem. 2008 Mar 14;283(11):7128-34. doi: 10.1074/jbc.M709902200. Epub 2008 Jan 7.


tRNA(Pro) anticodon recognition by Thermus thermophilus prolyl-tRNA synthetase.

Cusack S, Yaremchuk A, Krikliviy I, Tukalo M.

Structure. 1998 Jan 15;6(1):101-8.


Chemical modification and site-directed mutagenesis of the single cysteine in motif 3 of class II Escherichia coli prolyl-tRNA synthetase.

Stehlin C, Heacock DH 2nd, Liu H, Musier-Forsyth K.

Biochemistry. 1997 Mar 11;36(10):2932-8.


Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline.

Adachi R, Okada K, Skene R, Ogawa K, Miwa M, Tsuchinaga K, Ohkubo S, Henta T, Kawamoto T.

Biochem Biophys Res Commun. 2017 Jun 24;488(2):393-399. doi: 10.1016/j.bbrc.2017.05.064. Epub 2017 May 10.


Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.

Son J, Lee EH, Park M, Kim JH, Kim J, Kim S, Jeon YH, Hwang KY.

Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2136-45. doi: 10.1107/S0907444913020556. Epub 2013 Sep 20.


Hydrolytic editing by a class II aminoacyl-tRNA synthetase.

Beuning PJ, Musier-Forsyth K.

Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8916-20.


Substrate and enzyme functional groups contribute to translational quality control by bacterial prolyl-tRNA synthetase.

Kumar S, Das M, Hadad CM, Musier-Forsyth K.

J Phys Chem B. 2012 Jun 14;116(23):6991-9. doi: 10.1021/jp300845h. Epub 2012 Apr 11.


Prevention of mis-aminoacylation of a dual-specificity aminoacyl-tRNA synthetase.

Lipman RS, Wang J, Sowers KR, Hou YM.

J Mol Biol. 2002 Feb 1;315(5):943-9.


Cys-tRNA(Pro) editing by Haemophilus influenzae YbaK via a novel synthetase.YbaK.tRNA ternary complex.

An S, Musier-Forsyth K.

J Biol Chem. 2005 Oct 14;280(41):34465-72. Epub 2005 Aug 8.

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