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Items: 1 to 20 of 199

1.

Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility.

Jakab RL, Collaco AM, Ameen NA.

Dig Dis Sci. 2012 Nov;57(11):2826-45. doi: 10.1007/s10620-012-2352-8. Epub 2012 Aug 25.

2.

Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine.

Jakab RL, Collaco AM, Ameen NA.

Am J Physiol Gastrointest Liver Physiol. 2011 Jan;300(1):G82-98. doi: 10.1152/ajpgi.00245.2010. Epub 2010 Oct 28.

3.

Cell-specific effects of luminal acid, bicarbonate, cAMP, and carbachol on transporter trafficking in the intestine.

Jakab RL, Collaco AM, Ameen NA.

Am J Physiol Gastrointest Liver Physiol. 2012 Oct 15;303(8):G937-50. doi: 10.1152/ajpgi.00452.2011. Epub 2012 Aug 30.

4.

Lubiprostone prevents nonsteroidal anti-inflammatory drug-induced small intestinal damage by suppressing the expression of inflammatory mediators via EP4 receptors.

Hayashi S, Kurata N, Yamaguchi A, Amagase K, Takeuchi K.

J Pharmacol Exp Ther. 2014 Jun;349(3):470-9. doi: 10.1124/jpet.114.213991. Epub 2014 Apr 8.

5.

May the truth be with you: lubiprostone as EP receptor agonist/ClC-2 internalizing "inhibitor".

Akiba Y, Kaunitz JD.

Dig Dis Sci. 2012 Nov;57(11):2740-2. doi: 10.1007/s10620-012-2410-2. No abstract available.

PMID:
23001408
6.

Characterization of CFTR High Expresser cells in the intestine.

Jakab RL, Collaco AM, Ameen NA.

Am J Physiol Gastrointest Liver Physiol. 2013 Sep 15;305(6):G453-65. doi: 10.1152/ajpgi.00094.2013. Epub 2013 Jul 18.

7.

Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator.

Bijvelds MJ, Bot AG, Escher JC, De Jonge HR.

Gastroenterology. 2009 Sep;137(3):976-85. doi: 10.1053/j.gastro.2009.05.037. Epub 2009 May 18.

PMID:
19454284
8.

Electroneutral sodium absorption and electrogenic anion secretion across murine small intestine are regulated in parallel.

Gawenis LR, Hut H, Bot AG, Shull GE, de Jonge HR, Stien X, Miller ML, Clarke LL.

Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287(6):G1140-9. Epub 2004 Jul 29.

9.

cAMP inhibition of murine intestinal Na/H exchange requires CFTR-mediated cell shrinkage of villus epithelium.

Gawenis LR, Franklin CL, Simpson JE, Palmer BA, Walker NM, Wiggins TM, Clarke LL.

Gastroenterology. 2003 Oct;125(4):1148-63.

PMID:
14517798
10.

Ion transport mechanisms linked to bicarbonate secretion in the esophageal submucosal glands.

Abdulnour-Nakhoul S, Nakhoul HN, Kalliny MI, Gyftopoulos A, Rabon E, Doetjes R, Brown K, Nakhoul NL.

Am J Physiol Regul Integr Comp Physiol. 2011 Jul;301(1):R83-96. doi: 10.1152/ajpregu.00648.2010. Epub 2011 Apr 6.

11.

Lubiprostone targets prostanoid EP₄ receptors in ovine airways.

Cuthbert AW.

Br J Pharmacol. 2011 Jan;162(2):508-20. doi: 10.1111/j.1476-5381.2010.01058.x.

13.

Identification of the fatty acid activation site on human ClC-2.

Cuppoletti J, Tewari KP, Chakrabarti J, Malinowska DH.

Am J Physiol Cell Physiol. 2017 Jun 1;312(6):C707-C723. doi: 10.1152/ajpcell.00267.2016. Epub 2017 Apr 19.

PMID:
28424169
14.

Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport.

Collaco AM, Jakab RL, Hoekstra NE, Mitchell KA, Brooks A, Ameen NA.

Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1;305(3):G258-75. doi: 10.1152/ajpgi.00485.2012. Epub 2013 Jun 6.

15.

Lubiprostone activates CFTR, but not ClC-2, via the prostaglandin receptor (EP(4)).

Norimatsu Y, Moran AR, MacDonald KD.

Biochem Biophys Res Commun. 2012 Sep 28;426(3):374-9. doi: 10.1016/j.bbrc.2012.08.097. Epub 2012 Aug 29.

16.

Carbachol-induced colonic mucus formation requires transport via NKCC1, K⁺ channels and CFTR.

Gustafsson JK, Lindén SK, Alwan AH, Scholte BJ, Hansson GC, Sjövall H.

Pflugers Arch. 2015 Jul;467(7):1403-1415. doi: 10.1007/s00424-014-1595-y. Epub 2014 Aug 21.

18.

Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo.

Singh AK, Liu Y, Riederer B, Engelhardt R, Thakur BK, Soleimani M, Seidler U.

J Physiol. 2013 Nov 1;591(21):5377-91. doi: 10.1113/jphysiol.2013.254854. Epub 2013 Sep 9.

19.

Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota.

Musch MW, Wang Y, Claud EC, Chang EB.

Dig Dis Sci. 2013 Mar;58(3):668-77. doi: 10.1007/s10620-012-2509-5. Epub 2013 Jan 18.

20.

Lubiprostone activates Cl- secretion via cAMP signaling and increases membrane CFTR in the human colon carcinoma cell line, T84.

Ao M, Venkatasubramanian J, Boonkaewwan C, Ganesan N, Syed A, Benya RV, Rao MC.

Dig Dis Sci. 2011 Feb;56(2):339-51. doi: 10.1007/s10620-010-1495-8. Epub 2010 Dec 8.

PMID:
21140215

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