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Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak.

Melarangi T, Zhuang J, Lin K, Rockliffe N, Bosanquet AG, Oates M, Slupsky JR, Pettitt AR.

Cell Death Dis. 2012 Aug 16;3:e372. doi: 10.1038/cddis.2012.102.


BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells.

Sharma A, Singh K, Mazumder S, Hill BT, Kalaycio M, Almasan A.

Cell Death Dis. 2013 May 16;4:e628. doi: 10.1038/cddis.2013.155.


Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa.

Inoue S, Riley J, Gant TW, Dyer MJ, Cohen GM.

Leukemia. 2007 Aug;21(8):1773-82.


AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts.

González-Gironès DM, Moncunill-Massaguer C, Iglesias-Serret D, Cosialls AM, Pérez-Perarnau A, Palmeri CM, Rubio-Patiño C, Villunger A, Pons G, Gil J.

Apoptosis. 2013 Aug;18(8):1008-16. doi: 10.1007/s10495-013-0850-6.


The BH3-only protein Puma plays an essential role in p53-mediated apoptosis of chronic lymphocytic leukemia cells.

Zhu HJ, Liu L, Fan L, Zhang LN, Fang C, Zou ZJ, Li JY, Xu W.

Leuk Lymphoma. 2013 Dec;54(12):2712-9. doi: 10.3109/10428194.2013.787613.


MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.

Pei XY, Dai Y, Tenorio S, Lu J, Harada H, Dent P, Grant S.

Blood. 2007 Sep 15;110(6):2092-101.


Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia.

Bellosillo B, Villamor N, López-Guillermo A, Marcé S, Bosch F, Campo E, Montserrat E, Colomer D.

Blood. 2002 Sep 1;100(5):1810-6.


Regulation of bim in glucocorticoid-mediated osteoblast apoptosis.

Espina B, Liang M, Russell RG, Hulley PA.

J Cell Physiol. 2008 May;215(2):488-96.


The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.

Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM.

J Biol Chem. 2011 Mar 18;286(11):9382-92. doi: 10.1074/jbc.M110.203638.


Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection.

Hallaert DY, Spijker R, Jak M, Derks IA, Alves NL, Wensveen FM, de Boer JP, de Jong D, Green SR, van Oers MH, Eldering E.

Cell Death Differ. 2007 Nov;14(11):1958-67.


Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor.

Miller AV, Hicks MA, Nakajima W, Richardson AC, Windle JJ, Harada H.

PLoS One. 2013;8(4):e60685. doi: 10.1371/journal.pone.0060685.


P53, MDM-2, BAX and BCL-2 and drug resistance in chronic lymphocytic leukemia.

Johnston JB, Daeninck P, Verburg L, Lee K, Williams G, Israels LG, Mowat MR, Begleiter A.

Leuk Lymphoma. 1997 Aug;26(5-6):435-49.


Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells.

Heidari N, Miller AV, Hicks MA, Marking CB, Harada H.

Cell Death Dis. 2012 Jul 19;3:e349. doi: 10.1038/cddis.2012.89.


MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM.

Rambal AA, Panaguiton ZL, Kramer L, Grant S, Harada H.

Leukemia. 2009 Oct;23(10):1744-54. doi: 10.1038/leu.2009.80.


Phenylarsine oxide induces apoptosis in Bax- and Bak-deficient cells through upregulation of Bim.

Ni B, Ma Q, Li B, Zhao L, Liu Y, Zhu Y, Chen Q.

Clin Cancer Res. 2012 Jan 1;18(1):140-51. doi: 10.1158/1078-0432.CCR-10-3450.


AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.

Santidrián AF, González-Gironès DM, Iglesias-Serret D, Coll-Mulet L, Cosialls AM, de Frias M, Campàs C, González-Barca E, Alonso E, Labi V, Viollet B, Benito A, Pons G, Villunger A, Gil J.

Blood. 2010 Oct 21;116(16):3023-32. doi: 10.1182/blood-2010-05-283960.


Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM.

Alonso R, López-Guerra M, Upshaw R, Bantia S, Smal C, Bontemps F, Manz C, Mehrling T, Villamor N, Campo E, Montserrat E, Colomer D.

Blood. 2009 Aug 20;114(8):1563-75. doi: 10.1182/blood-2009-02-207654.


Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.

Mol Cell. 2009 Nov 13;36(3):487-99. doi: 10.1016/j.molcel.2009.09.030.


Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S.

Cancer Res. 2013 Feb 15;73(4):1340-51. doi: 10.1158/0008-5472.CAN-12-1365.

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