Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 163


Phosphorylation of NLRC4 is critical for inflammasome activation.

Qu Y, Misaghi S, Izrael-Tomasevic A, Newton K, Gilmour LL, Lamkanfi M, Louie S, Kayagaki N, Liu J, Kömüves L, Cupp JE, Arnott D, Monack D, Dixit VM.

Nature. 2012 Oct 25;490(7421):539-42. doi: 10.1038/nature11429. Epub 2012 Aug 12.


Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5.

Matusiak M, Van Opdenbosch N, Vande Walle L, Sirard JC, Kanneganti TD, Lamkanfi M.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1541-6. doi: 10.1073/pnas.1417945112. Epub 2015 Jan 20.


The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

Zhao Y, Yang J, Shi J, Gong YN, Lu Q, Xu H, Liu L, Shao F.

Nature. 2011 Sep 14;477(7366):596-600. doi: 10.1038/nature10510.


Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.

Suzuki S, Franchi L, He Y, Muñoz-Planillo R, Mimuro H, Suzuki T, Sasakawa C, Núñez G.

PLoS Pathog. 2014 Feb 6;10(2):e1003926. doi: 10.1371/journal.ppat.1003926. eCollection 2014 Feb.


NLRP3 recruitment by NLRC4 during Salmonella infection.

Qu Y, Misaghi S, Newton K, Maltzman A, Izrael-Tomasevic A, Arnott D, Dixit VM.

J Exp Med. 2016 May 30;213(6):877-85. doi: 10.1084/jem.20132234. Epub 2016 May 2.


Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity.

Kofoed EM, Vance RE.

Nature. 2011 Aug 28;477(7366):592-5. doi: 10.1038/nature10394.


The CARD plays a critical role in ASC foci formation and inflammasome signalling.

Proell M, Gerlic M, Mace PD, Reed JC, Riedl SJ.

Biochem J. 2013 Feb 1;449(3):613-21. doi: 10.1042/BJ20121198.


Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes.

Wu J, Fernandes-Alnemri T, Alnemri ES.

J Clin Immunol. 2010 Sep;30(5):693-702. doi: 10.1007/s10875-010-9425-2. Epub 2010 May 20.


Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.

von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE.

Nature. 2012 Oct 4;490(7418):107-11. doi: 10.1038/nature11351. Epub 2012 Aug 19.


The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus.

Zhao Y, Shao F.

Immunol Rev. 2015 May;265(1):85-102. doi: 10.1111/imr.12293. Review.


Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection.

Gomes MT, Campos PC, Oliveira FS, Corsetti PP, Bortoluci KR, Cunha LD, Zamboni DS, Oliveira SC.

J Immunol. 2013 Apr 1;190(7):3629-38. doi: 10.4049/jimmunol.1202817. Epub 2013 Mar 4.


Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin.

Halff EF, Diebolder CA, Versteeg M, Schouten A, Brondijk TH, Huizinga EG.

J Biol Chem. 2012 Nov 9;287(46):38460-72. doi: 10.1074/jbc.M112.393512. Epub 2012 Sep 25.


Differential requirements for NAIP5 in activation of the NLRC4 inflammasome.

Lightfield KL, Persson J, Trinidad NJ, Brubaker SW, Kofoed EM, Sauer JD, Dunipace EA, Warren SE, Miao EA, Vance RE.

Infect Immun. 2011 Apr;79(4):1606-14. doi: 10.1128/IAI.01187-10. Epub 2011 Jan 31.


Novel role of PKR in inflammasome activation and HMGB1 release.

Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ.

Nature. 2012 Aug 30;488(7413):670-4. doi: 10.1038/nature11290.


Nlrc4/Ipaf/CLAN/CARD12: more than a flagellin sensor.

Abdelaziz DH, Amr K, Amer AO.

Int J Biochem Cell Biol. 2010 Jun;42(6):789-91. doi: 10.1016/j.biocel.2010.01.003. Epub 2010 Jan 11. Review.


The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge.

Chen KW, Groß CJ, Sotomayor FV, Stacey KJ, Tschopp J, Sweet MJ, Schroder K.

Cell Rep. 2014 Jul 24;8(2):570-82. doi: 10.1016/j.celrep.2014.06.028. Epub 2014 Jul 17.


Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation.

Zhao C, Gillette DD, Li X, Zhang Z, Wen H.

J Biol Chem. 2014 Jun 13;289(24):17020-9. doi: 10.1074/jbc.M114.563114. Epub 2014 May 5.


Caspase-11 activation in response to bacterial secretion systems that access the host cytosol.

Casson CN, Copenhaver AM, Zwack EE, Nguyen HT, Strowig T, Javdan B, Bradley WP, Fung TC, Flavell RA, Brodsky IE, Shin S.

PLoS Pathog. 2013;9(6):e1003400. doi: 10.1371/journal.ppat.1003400. Epub 2013 Jun 6.


Salmonella downregulates Nod-like receptor family CARD domain containing protein 4 expression to promote its survival in B cells by preventing inflammasome activation and cell death.

Perez-Lopez A, Rosales-Reyes R, Alpuche-Aranda CM, Ortiz-Navarrete V.

J Immunol. 2013 Feb 1;190(3):1201-9. doi: 10.4049/jimmunol.1200415. Epub 2013 Jan 2.


Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.

Man SM, Hopkins LJ, Nugent E, Cox S, Glück IM, Tourlomousis P, Wright JA, Cicuta P, Monie TP, Bryant CE.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7403-8. doi: 10.1073/pnas.1402911111. Epub 2014 May 6.

Supplemental Content

Support Center