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Alzheimer's disease in a dish: promises and challenges of human stem cell models.

Young JE, Goldstein LS.

Hum Mol Genet. 2012 Oct 15;21(R1):R82-9. Epub 2012 Aug 2. Review.


Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.

Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS.

Nature. 2012 Jan 25;482(7384):216-20. doi: 10.1038/nature10821.


A human stem cell model of early Alzheimer's disease pathology in Down syndrome.

Shi Y, Kirwan P, Smith J, MacLean G, Orkin SH, Livesey FJ.

Sci Transl Med. 2012 Mar 7;4(124):124ra29. doi: 10.1126/scitranslmed.3003771. Epub 2012 Feb 15.


N-butylidenephthalide attenuates Alzheimer's disease-like cytopathy in Down syndrome induced pluripotent stem cell-derived neurons.

Chang CY, Chen SM, Lu HE, Lai SM, Lai PS, Shen PW, Chen PY, Shen CI, Harn HJ, Lin SZ, Hwang SM, Su HL.

Sci Rep. 2015 Mar 4;5:8744. doi: 10.1038/srep08744.


The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons.

Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL.

Hum Mol Genet. 2014 Jul 1;23(13):3523-36. doi: 10.1093/hmg/ddu064. Epub 2014 Feb 12.


Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks.

Hossini AM, Megges M, Prigione A, Lichtner B, Toliat MR, Wruck W, Schröter F, Nuernberg P, Kroll H, Makrantonaki E, Zouboulis CC, Adjaye J.

BMC Genomics. 2015 Feb 14;16:84. doi: 10.1186/s12864-015-1262-5. Erratum in: BMC Genomics. 2015;16:433. Zoubouliss, Christos C [corrected to Zouboulis, Christos C].


Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease.

Brownjohn PW, Smith J, Portelius E, Serneels L, Kvartsberg H, De Strooper B, Blennow K, Zetterberg H, Livesey FJ.

Stem Cell Reports. 2017 Apr 11;8(4):870-882. doi: 10.1016/j.stemcr.2017.02.006. Epub 2017 Mar 9.


[Cellular models for individualized medicine in Alzheimer's disease using patient-derived induced pluripotent stem cells].

Asai M, Shirotani K, Kondo T, Inoue H, Iwata N.

Nihon Yakurigaku Zasshi. 2014 Jan;143(1):23-6. Review. Japanese. No abstract available.


Alzheimer's disease-related amyloid-β induces synaptotoxicity in human iPS cell-derived neurons.

Nieweg K, Andreyeva A, van Stegen B, Tanriöver G, Gottmann K.

Cell Death Dis. 2015 Apr 2;6:e1709. doi: 10.1038/cddis.2015.72.


Role of tau protein in neuronal damage in Alzheimer's disease and Down syndrome.

Cárdenas AM, Ardiles AO, Barraza N, Baéz-Matus X, Caviedes P.

Arch Med Res. 2012 Nov;43(8):645-54. doi: 10.1016/j.arcmed.2012.10.012. Epub 2012 Nov 7. Review.


Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP.

Granic A, Padmanabhan J, Norden M, Potter H.

Mol Biol Cell. 2010 Feb 15;21(4):511-20. doi: 10.1091/mbc.E09-10-0850. Epub 2009 Dec 23.


Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer's disease.

Ooi L, Sidhu K, Poljak A, Sutherland G, O'Connor MD, Sachdev P, Münch G.

J Neural Transm (Vienna). 2013 Jan;120(1):103-11. doi: 10.1007/s00702-012-0839-2. Epub 2012 Jun 13. Review.


Alzheimer's disease.

De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV.

Subcell Biochem. 2012;65:329-52. doi: 10.1007/978-94-007-5416-4_14. Review.


Exploring Alzheimer molecular pathology in Down's syndrome cerebrospinal fluid.

Portelius E, Soininen H, Andreasson U, Zetterberg H, Persson R, Karlsson G, Blennow K, Herukka SK, Mattsson N.

Neurodegener Dis. 2014;14(2):98-106. doi: 10.1159/000358800. Epub 2014 Jun 27.


Cortical Differentiation of Human Pluripotent Cells for In Vitro Modeling of Alzheimer's Disease.

Saurat NG, Livesey FJ, Moore S.

Methods Mol Biol. 2016;1303:267-78. doi: 10.1007/978-1-4939-2627-5_16.


Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol.

Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I.

J Neurosci. 2003 Sep 17;23(24):8513-25.


APP metabolism regulates tau proteostasis in human cerebral cortex neurons.

Moore S, Evans LD, Andersson T, Portelius E, Smith J, Dias TB, Saurat N, McGlade A, Kirwan P, Blennow K, Hardy J, Zetterberg H, Livesey FJ.

Cell Rep. 2015 May 5;11(5):689-96. doi: 10.1016/j.celrep.2015.03.068. Epub 2015 Apr 23.

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