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Items: 1 to 20 of 79

1.

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase.

Talukdar S, Oh DY, Bandyopadhyay G, Li D, Xu J, McNelis J, Lu M, Li P, Yan Q, Zhu Y, Ofrecio J, Lin M, Brenner MB, Olefsky JM.

Nat Med. 2012 Sep;18(9):1407-12.

2.

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance.

Lee BC, Lee J.

Biochim Biophys Acta. 2014 Mar;1842(3):446-62. doi: 10.1016/j.bbadis.2013.05.017. Epub 2013 May 22. Review.

3.

Macrophage migration inhibitory factor deficiency ameliorates high-fat diet induced insulin resistance in mice with reduced adipose inflammation and hepatic steatosis.

Finucane OM, Reynolds CM, McGillicuddy FC, Harford KA, Morrison M, Baugh J, Roche HM.

PLoS One. 2014 Nov 20;9(11):e113369. doi: 10.1371/journal.pone.0113369. eCollection 2014.

4.

Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance.

Priceman SJ, Kujawski M, Shen S, Cherryholmes GA, Lee H, Zhang C, Kruper L, Mortimer J, Jove R, Riggs AD, Yu H.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13079-84. doi: 10.1073/pnas.1311557110. Epub 2013 Jul 22.

5.

Long-acting glucose-dependent insulinotropic polypeptide ameliorates obesity-induced adipose tissue inflammation.

Varol C, Zvibel I, Spektor L, Mantelmacher FD, Vugman M, Thurm T, Khatib M, Elmaliah E, Halpern Z, Fishman S.

J Immunol. 2014 Oct 15;193(8):4002-9. doi: 10.4049/jimmunol.1401149. Epub 2014 Sep 12.

6.

Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice.

Hussaarts L, García-Tardón N, van Beek L, Heemskerk MM, Haeberlein S, van der Zon GC, Ozir-Fazalalikhan A, Berbée JF, Willems van Dijk K, van Harmelen V, Yazdanbakhsh M, Guigas B.

FASEB J. 2015 Jul;29(7):3027-39. doi: 10.1096/fj.14-266239. Epub 2015 Apr 7.

7.

From neutrophils to macrophages: differences in regional adipose tissue depots.

Dam V, Sikder T, Santosa S.

Obes Rev. 2016 Jan;17(1):1-17. doi: 10.1111/obr.12335. Epub 2015 Dec 14. Review.

PMID:
26667065
8.

Thrombospondin1 deficiency reduces obesity-associated inflammation and improves insulin sensitivity in a diet-induced obese mouse model.

Li Y, Tong X, Rumala C, Clemons K, Wang S.

PLoS One. 2011;6(10):e26656. doi: 10.1371/journal.pone.0026656. Epub 2011 Oct 24.

9.

Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue.

Harford KA, Reynolds CM, McGillicuddy FC, Roche HM.

Proc Nutr Soc. 2011 Nov;70(4):408-17. doi: 10.1017/S0029665111000565. Epub 2011 Aug 12. Review.

PMID:
21835098
10.

γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice.

Mehta P, Nuotio-Antar AM, Smith CW.

J Leukoc Biol. 2015 Jan;97(1):121-34. doi: 10.1189/jlb.3A0414-211RR. Epub 2014 Nov 13.

11.

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance.

Jia L, Vianna CR, Fukuda M, Berglund ED, Liu C, Tao C, Sun K, Liu T, Harper MJ, Lee CE, Lee S, Scherer PE, Elmquist JK.

Nat Commun. 2014 May 12;5:3878. doi: 10.1038/ncomms4878.

12.

IL-21 is a major negative regulator of IRF4-dependent lipolysis affecting Tregs in adipose tissue and systemic insulin sensitivity.

Fabrizi M, Marchetti V, Mavilio M, Marino A, Casagrande V, Cavalera M, Moreno-Navarrete JM, Mezza T, Sorice GP, Fiorentino L, Menghini R, Lauro R, Monteleone G, Giaccari A, Fernandez Real JM, Federici M.

Diabetes. 2014 Jun;63(6):2086-96. doi: 10.2337/db13-0939. Epub 2014 Jan 15.

13.

MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.

Ballak DB, van Essen P, van Diepen JA, Jansen H, Hijmans A, Matsuguchi T, Sparrer H, Tack CJ, Netea MG, Joosten LA, Stienstra R.

PLoS One. 2014 Feb 24;9(2):e89615. doi: 10.1371/journal.pone.0089615. eCollection 2014.

14.

Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance.

Wang Q, Xie Z, Zhang W, Zhou J, Wu Y, Zhang M, Zhu H, Zou MH.

Diabetes. 2014 Dec;63(12):4172-85. doi: 10.2337/db14-0026. Epub 2014 Jul 14.

15.

A novel benzenediamine derivative FC98 reduces insulin resistance in high fat diet-induced obese mice by suppression of metaflammation.

Chen C, Zhang W, Shi H, Zhuo Y, Yang G, Zhang A, Hou Y, Xiang Tan R, Li E.

Eur J Pharmacol. 2015 Aug 15;761:298-308. doi: 10.1016/j.ejphar.2015.06.021. Epub 2015 Jun 16.

PMID:
26086863
16.

Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice.

Nomiyama T, Perez-Tilve D, Ogawa D, Gizard F, Zhao Y, Heywood EB, Jones KL, Kawamori R, Cassis LA, Tschöp MH, Bruemmer D.

J Clin Invest. 2007 Oct;117(10):2877-88.

17.

Valsartan protects pancreatic islets and adipose tissue from the inflammatory and metabolic consequences of a high-fat diet in mice.

Cole BK, Keller SR, Wu R, Carter JD, Nadler JL, Nunemaker CS.

Hypertension. 2010 Mar;55(3):715-21. doi: 10.1161/HYPERTENSIONAHA.109.148049. Epub 2010 Jan 25.

18.

T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans.

McLaughlin T, Liu LF, Lamendola C, Shen L, Morton J, Rivas H, Winer D, Tolentino L, Choi O, Zhang H, Hui Yen Chng M, Engleman E.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2637-43. doi: 10.1161/ATVBAHA.114.304636. Epub 2014 Oct 23.

19.

Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance.

Kim F, Pham M, Maloney E, Rizzo NO, Morton GJ, Wisse BE, Kirk EA, Chait A, Schwartz MW.

Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1982-8. doi: 10.1161/ATVBAHA.108.169722. Epub 2008 Sep 4.

20.

The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1.

Yang Z, Wang X, He Y, Qi L, Yu L, Xue B, Shi H.

PLoS One. 2012;7(11):e49935. doi: 10.1371/journal.pone.0049935. Epub 2012 Nov 21.

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