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Items: 1 to 20 of 94

1.

Comparative oncogenomics implicates the neurofibromin 1 gene (NF1) as a breast cancer driver.

Wallace MD, Pfefferle AD, Shen L, McNairn AJ, Cerami EG, Fallon BL, Rinaldi VD, Southard TL, Perou CM, Schimenti JC.

Genetics. 2012 Oct;192(2):385-96. doi: 10.1534/genetics.112.142802. Epub 2012 Jul 30.

2.

Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells.

Herschkowitz JI, Zhao W, Zhang M, Usary J, Murrow G, Edwards D, Knezevic J, Greene SB, Darr D, Troester MA, Hilsenbeck SG, Medina D, Perou CM, Rosen JM.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2778-83. doi: 10.1073/pnas.1018862108. Epub 2011 Jun 1.

3.

Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients.

Ronowicz A, Janaszak-Jasiecka A, Skokowski J, Madanecki P, Bartoszewski R, Bałut M, Seroczyńska B, Kochan K, Bogdan A, Butkus M, Pęksa R, Ratajska M, Kuźniacka A, Wasąg B, Gucwa M, Krzyżanowski M, Jaśkiewicz J, Jankowski Z, Forsberg L, Ochocka JR, Limon J, Crowley MR, Buckley PG, Messiaen L, Dumanski JP, Piotrowski A.

Hum Mutat. 2015 Nov;36(11):1088-99. doi: 10.1002/humu.22845. Epub 2015 Aug 14.

PMID:
26219265
5.

Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurofibromin-deficient mice.

Sharma R, Wu X, Rhodes SD, Chen S, He Y, Yuan J, Li J, Yang X, Li X, Jiang L, Kim ET, Stevenson DA, Viskochil D, Xu M, Yang FC.

Hum Mol Genet. 2013 Dec 1;22(23):4818-28. doi: 10.1093/hmg/ddt333. Epub 2013 Jul 17.

6.

Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations.

Sangha N, Wu R, Kuick R, Powers S, Mu D, Fiander D, Yuen K, Katabuchi H, Tashiro H, Fearon ER, Cho KR.

Neoplasia. 2008 Dec;10(12):1362-72, following 1372.

7.

The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways.

Shapira S, Barkan B, Friedman E, Kloog Y, Stein R.

Cell Death Differ. 2007 May;14(5):895-906. Epub 2006 Nov 10. Erratum in: Cell Death Differ. 2007 May;14(5):1070. Fridman, E [corrected to Friedman, E].

8.

Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer.

Treekitkarnmongkol W, Katayama H, Kai K, Sasai K, Jones JC, Wang J, Shen L, Sahin AA, Gagea M, Ueno NT, Creighton CJ, Sen S.

Carcinogenesis. 2016 Dec;37(12):1180-1189. Epub 2016 Sep 13.

PMID:
27624071
9.

Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers.

Holstege H, van Beers E, Velds A, Liu X, Joosse SA, Klarenbeek S, Schut E, Kerkhoven R, Klijn CN, Wessels LF, Nederlof PM, Jonkers J.

BMC Cancer. 2010 Aug 24;10:455. doi: 10.1186/1471-2407-10-455.

10.

Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras.

Hollstein PE, Cichowski K.

Cancer Discov. 2013 Aug;3(8):880-93. doi: 10.1158/2159-8290.CD-13-0146. Epub 2013 May 9.

11.

Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer.

Warmoes M, Jaspers JE, Pham TV, Piersma SR, Oudgenoeg G, Massink MP, Waisfisz Q, Rottenberg S, Boven E, Jonkers J, Jimenez CR.

Mol Cell Proteomics. 2012 Jul;11(7):M111.013334. doi: 10.1074/mcp.M111.013334. Epub 2012 Feb 24.

12.

NF1 deficiency causes Bcl-xL upregulation in Schwann cells derived from neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.

Park HJ, Lee SJ, Sohn YB, Jin HS, Han JH, Kim YB, Yim H, Jeong SY.

Int J Oncol. 2013 Feb;42(2):657-66. doi: 10.3892/ijo.2012.1751. Epub 2012 Dec 24.

PMID:
23292448
13.

Potential mouse tumor model for pre-clinical testing of mage-specific breast cancer vaccines.

Sypniewska RK, Hoflack L, Bearss DJ, Gravekamp C.

Breast Cancer Res Treat. 2002 Jun;74(3):221-33.

PMID:
12211215
14.

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor.

Cichowski K, Santiago S, Jardim M, Johnson BW, Jacks T.

Genes Dev. 2003 Feb 15;17(4):449-54.

15.

NF1 regulates a Ras-dependent vascular smooth muscle proliferative injury response.

Xu J, Ismat FA, Wang T, Yang J, Epstein JA.

Circulation. 2007 Nov 6;116(19):2148-56. Epub 2007 Oct 22.

16.

The neurofibromin 1 type I isoform predominance characterises female population affected by sporadic breast cancer: preliminary data.

Marrero D, Peralta R, Valdivia A, De la Mora A, Romero P, Parra M, Mendoza N, Mendoza M, Rodriguez D, Camacho E, Duarte A, Castelazo G, Vanegas E, Garcia I, Vargas C, Arenas D, Jimenez F, Salcedo M.

J Clin Pathol. 2012 May;65(5):419-23. doi: 10.1136/jclinpath-2011-200569. Epub 2012 Mar 12.

PMID:
22412049
17.

Integration of DNA copy number alterations and prognostic gene expression signatures in breast cancer patients.

Horlings HM, Lai C, Nuyten DS, Halfwerk H, Kristel P, van Beers E, Joosse SA, Klijn C, Nederlof PM, Reinders MJ, Wessels LF, van de Vijver MJ.

Clin Cancer Res. 2010 Jan 15;16(2):651-63. doi: 10.1158/1078-0432.CCR-09-0709. Epub 2010 Jan 12.

18.

An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers.

Natrajan R, Weigelt B, Mackay A, Geyer FC, Grigoriadis A, Tan DS, Jones C, Lord CJ, Vatcheva R, Rodriguez-Pinilla SM, Palacios J, Ashworth A, Reis-Filho JS.

Breast Cancer Res Treat. 2010 Jun;121(3):575-89. doi: 10.1007/s10549-009-0501-3. Epub 2009 Aug 18.

PMID:
19688261
19.

Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein.

Goddio MV, Gattelli A, Slomiansky V, Lacunza E, Gingerich T, Tocci JM, Facchinetti MM, Curino AC, LaMarre J, Abba MC, Kordon EC.

Breast Cancer Res Treat. 2012 Oct;135(3):749-58. doi: 10.1007/s10549-012-2216-0. Epub 2012 Aug 29.

PMID:
22968621
20.

Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles.

Klopfleisch R, Lenze D, Hummel M, Gruber AD.

BMC Cancer. 2010 Nov 9;10:618. doi: 10.1186/1471-2407-10-618.

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