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Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.

Corominas-Faja B, Quirantes-Piné R, Oliveras-Ferraros C, Vazquez-Martin A, Cufí S, Martin-Castillo B, Micol V, Joven J, Segura-Carretero A, Menendez JA.

Aging (Albany NY). 2012 Jul;4(7):480-98.


Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK.

Storozhuk Y, Hopmans SN, Sanli T, Barron C, Tsiani E, Cutz JC, Pond G, Wright J, Singh G, Tsakiridis T.

Br J Cancer. 2013 May 28;108(10):2021-32. doi: 10.1038/bjc.2013.187. Epub 2013 Apr 30.


Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin.

Zakikhani M, Bazile M, Hashemi S, Javeshghani S, Avizonis D, St Pierre J, Pollak MN.

PLoS One. 2012;7(11):e49513. doi: 10.1371/journal.pone.0049513. Epub 2012 Nov 21.


Genomics: Drugs, diabetes and cancer.

Birnbaum MJ, Shaw RJ.

Nature. 2011 Feb 17;470(7334):338-9. doi: 10.1038/470338a. No abstract available.


Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling.

Halicka HD, Zhao H, Li J, Traganos F, Zhang S, Lee M, Darzynkiewicz Z.

Aging (Albany NY). 2011 Oct;3(10):1028-38.


One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metformin.

Menendez JA, Joven J.

Aging (Albany NY). 2012 Dec;4(12):894-8.


Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group; Wellcome Trust Case Control Consortium 2, Zhou K, Bellenguez C, Spencer CC, Bennett AJ, Coleman RL, Tavendale R, Hawley SA, Donnelly LA, Schofield C, Groves CJ, Burch L, Carr F, Strange A, Freeman C, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Gray E, Hunt S, Jankowski J, Langford C, Markus HS, Mathew CG, Plomin R, Rautanen A, Sawcer SJ, Samani NJ, Trembath R, Viswanathan AC, Wood NW; MAGIC investigators, Harries LW, Hattersley AT, Doney AS, Colhoun H, Morris AD, Sutherland C, Hardie DG, Peltonen L, McCarthy MI, Holman RR, Palmer CN, Donnelly P, Pearson ER.

Nat Genet. 2011 Feb;43(2):117-20. doi: 10.1038/ng.735. Epub 2010 Dec 26.


The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program.

Florez JC, Jablonski KA, Taylor A, Mather K, Horton E, White NH, Barrett-Connor E, Knowler WC, Shuldiner AR, Pollin TI; Diabetes Prevention Program Research Group.

Diabetes Care. 2012 Sep;35(9):1864-7. Epub 2012 Jun 29.


AMP-activated protein kinase: a target for drugs both ancient and modern.

Hardie DG, Ross FA, Hawley SA.

Chem Biol. 2012 Oct 26;19(10):1222-36. doi: 10.1016/j.chembiol.2012.08.019. Review.


Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy.

Zhang Y, Storr SJ, Johnson K, Green AR, Rakha EA, Ellis IO, Morgan DA, Martin SG.

Oncotarget. 2014 Dec 30;5(24):12936-49.


Molecular pathways: preclinical models and clinical trials with metformin in breast cancer.

Thompson AM.

Clin Cancer Res. 2014 May 15;20(10):2508-15. doi: 10.1158/1078-0432.CCR-13-0354. Epub 2014 Mar 28.


[Metformin impact on purine metabolism in breast cancer].

Shatova OP, Butenko EV, Khomutov EV, Kaplun DS, Sedakov IE, Zinkovych II.

Biomed Khim. 2016 Mar;62(3):302-5. doi: 10.18097/PBMC20166203302. Russian.


Metabolic roles of AMPK and metformin in cancer cells.

Choi YK, Park KG.

Mol Cells. 2013 Oct;36(4):279-87. doi: 10.1007/s10059-013-0169-8. Epub 2013 Jun 19. Review.


The role of ATM in response to metformin treatment and activation of AMPK.

Yee SW, Chen L, Giacomini KM.

Nat Genet. 2012 Mar 28;44(4):359-60. doi: 10.1038/ng.2236. No abstract available.


[Metformin - new data for an "old", but efficient, safe and reliable antidiabetic drug].

Winkler G.

Orv Hetil. 2016 Jun 5;157(23):882-91. doi: 10.1556/650.2016.30485. Review. Hungarian.


Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation.

Fatt M, Hsu K, He L, Wondisford F, Miller FD, Kaplan DR, Wang J.

Stem Cell Reports. 2015 Dec 8;5(6):988-995. doi: 10.1016/j.stemcr.2015.10.014. Epub 2015 Nov 19.


The role of ATM in response to metformin treatment and activation of AMPK.

Zhou K, Bellenguez C, Sutherland C, Hardie G, Palmer C, Donnelly P, Pearson E.

Nat Genet. 2012 Mar 28;44(4):361-2. doi: 10.1038/ng.2234. No abstract available.


The role of ATM in response to metformin treatment and activation of AMPK.

Woods A, Leiper JM, Carling D.

Nat Genet. 2012 Mar 28;44(4):360-1. doi: 10.1038/ng.2235. No abstract available.


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