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Items: 1 to 20 of 88

1.

Methylation by Set9 modulates FoxO3 stability and transcriptional activity.

Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A.

Aging (Albany NY). 2012 Jul;4(7):462-79.

2.

Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death.

Xie Q, Hao Y, Tao L, Peng S, Rao C, Chen H, You H, Dong MQ, Yuan Z.

EMBO Rep. 2012 Apr;13(4):371-7. doi: 10.1038/embor.2012.25.

3.

The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.

Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, Brunet A.

J Biol Chem. 2007 Oct 12;282(41):30107-19. Epub 2007 Aug 20.

4.

Methylation of FoxO3 regulates neuronal cell death.

Zhu WG.

Acta Pharmacol Sin. 2012 May;33(5):577. doi: 10.1038/aps.2012.48. No abstract available.

5.

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.

Wang F, Chan CH, Chen K, Guan X, Lin HK, Tong Q.

Oncogene. 2012 Mar 22;31(12):1546-57. doi: 10.1038/onc.2011.347. Epub 2011 Aug 15.

PMID:
21841822
6.

E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors.

Xie Q, Peng S, Tao L, Ruan H, Yang Y, Li TM, Adams U, Meng S, Bi X, Dong MQ, Yuan Z.

J Biol Chem. 2014 Dec 5;289(49):34205-13. doi: 10.1074/jbc.M114.587170. Epub 2014 Oct 24.

7.

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.

Nishioka K, Chuikov S, Sarma K, Erdjument-Bromage H, Allis CD, Tempst P, Reinberg D.

Genes Dev. 2002 Feb 15;16(4):479-89.

8.

Regulation of p53 activity through lysine methylation.

Chuikov S, Kurash JK, Wilson JR, Xiao B, Justin N, Ivanov GS, McKinney K, Tempst P, Prives C, Gamblin SJ, Barlev NA, Reinberg D.

Nature. 2004 Nov 18;432(7015):353-60. Epub 2004 Nov 3.

9.

Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice.

Kurinna S, Stratton SA, Tsai WW, Akdemir KC, Gu W, Singh P, Goode T, Darlington GJ, Barton MC.

Hepatology. 2010 Sep;52(3):1023-32. doi: 10.1002/hep.23746.

10.

Methylation-mediated regulation of E2F1 in DNA damage-induced cell death.

Xie Q, Bai Y, Wu J, Sun Y, Wang Y, Zhang Y, Mei P, Yuan Z.

J Recept Signal Transduct Res. 2011 Apr;31(2):139-46. doi: 10.3109/10799893.2011.552914. Epub 2011 Feb 15.

PMID:
21320024
11.

FOXO3 selectively amplifies enhancer activity to establish target gene regulation.

Eijkelenboom A, Mokry M, Smits LM, Nieuwenhuis EE, Burgering BM.

Cell Rep. 2013 Dec 26;5(6):1664-78. doi: 10.1016/j.celrep.2013.11.031. Epub 2013 Dec 19.

12.

Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase.

Ko S, Ahn J, Song CS, Kim S, Knapczyk-Stwora K, Chatterjee B.

Mol Endocrinol. 2011 Mar;25(3):433-44. doi: 10.1210/me.2010-0482. Epub 2011 Jan 27.

13.

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.

Science. 2004 Mar 26;303(5666):2011-5. Epub 2004 Feb 19.

14.

The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor.

Renault VM, Thekkat PU, Hoang KL, White JL, Brady CA, Kenzelmann Broz D, Venturelli OS, Johnson TM, Oskoui PR, Xuan Z, Santo EE, Zhang MQ, Vogel H, Attardi LD, Brunet A.

Oncogene. 2011 Jul 21;30(29):3207-21. doi: 10.1038/onc.2011.35. Epub 2011 Mar 21.

15.

Computational identification and modeling of crosstalk between phosphorylation, O-β-glycosylation and methylation of FoxO3 and implications for cancer therapeutics.

Butt AM, Feng D, Idrees M, Tong Y, Lu J.

Int J Mol Sci. 2012;13(3):2918-38. doi: 10.3390/ijms13032918. Epub 2012 Mar 5.

16.

Multiple lysine methylation of PCAF by Set9 methyltransferase.

Masatsugu T, Yamamoto K.

Biochem Biophys Res Commun. 2009 Mar 27;381(1):22-6. doi: 10.1016/j.bbrc.2009.01.185. Epub 2009 Feb 7.

PMID:
19351588
17.

FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis.

Webb AE, Pollina EA, Vierbuchen T, Urbán N, Ucar D, Leeman DS, Martynoga B, Sewak M, Rando TA, Guillemot F, Wernig M, Brunet A.

Cell Rep. 2013 Aug 15;4(3):477-91. doi: 10.1016/j.celrep.2013.06.035. Epub 2013 Jul 25.

18.

Methylation, a new epigenetic mark for protein stability.

Yang XD, Lamb A, Chen LF.

Epigenetics. 2009 Oct 1;4(7):429-33. Epub 2009 Oct 10.

PMID:
19829087
19.

Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling.

Eijkelenboom A, Mokry M, de Wit E, Smits LM, Polderman PE, van Triest MH, van Boxtel R, Schulze A, de Laat W, Cuppen E, Burgering BM.

Mol Syst Biol. 2013;9:638. doi: 10.1038/msb.2012.74.

20.

FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop.

Lützner N, Kalbacher H, Krones-Herzig A, Rösl F.

PLoS One. 2012;7(7):e42166. doi: 10.1371/journal.pone.0042166. Epub 2012 Jul 27.

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