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Items: 1 to 20 of 116

1.

Structural basis for allosteric regulation of GPCRs by sodium ions.

Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, Han GW, Roth CB, Heitman LH, IJzerman AP, Cherezov V, Stevens RC.

Science. 2012 Jul 13;337(6091):232-6. doi: 10.1126/science.1219218.

2.

Structure of an agonist-bound human A2A adenosine receptor.

Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC.

Science. 2011 Apr 15;332(6027):322-7. doi: 10.1126/science.1202793. Epub 2011 Mar 10.

3.

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation.

Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG.

Nature. 2011 May 18;474(7352):521-5. doi: 10.1038/nature10136.

4.

The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor.

Gutiérrez-de-Terán H, Massink A, Rodríguez D, Liu W, Han GW, Joseph JS, Katritch I, Heitman LH, Xia L, Ijzerman AP, Cherezov V, Katritch V, Stevens RC.

Structure. 2013 Dec 3;21(12):2175-85. doi: 10.1016/j.str.2013.09.020. Epub 2013 Nov 7.

5.

Molecular Basis of Ligand Dissociation from the Adenosine A2A Receptor.

Guo D, Pan AC, Dror RO, Mocking T, Liu R, Heitman LH, Shaw DE, IJzerman AP.

Mol Pharmacol. 2016 May;89(5):485-91. doi: 10.1124/mol.115.102657. Epub 2016 Feb 12.

6.

Bridging molecular docking to membrane molecular dynamics to investigate GPCR-ligand recognition: the human A₂A adenosine receptor as a key study.

Sabbadin D, Ciancetta A, Moro S.

J Chem Inf Model. 2014 Jan 27;54(1):169-83. doi: 10.1021/ci400532b. Epub 2014 Jan 8.

PMID:
24359090
7.

Structural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist binding.

Keränen H, Gutiérrez-de-Terán H, Åqvist J.

PLoS One. 2014 Oct 6;9(10):e108492. doi: 10.1371/journal.pone.0108492. eCollection 2014.

8.

Communication over the network of binary switches regulates the activation of A2A adenosine receptor.

Lee Y, Choi S, Hyeon C.

PLoS Comput Biol. 2015 Feb 9;11(2):e1004044. doi: 10.1371/journal.pcbi.1004044. eCollection 2015 Feb.

9.

Crystallogenesis of adenosine A(2A) receptor-T4 lysozyme fusion protein: a practical route for the structure.

Ashok Y, Nanekar RT, Jaakola VP.

Methods Enzymol. 2013;520:175-98. doi: 10.1016/B978-0-12-391861-1.00008-3.

PMID:
23332700
10.

Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength.

Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Doré AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM.

J Med Chem. 2016 Jul 14;59(13):6470-9. doi: 10.1021/acs.jmedchem.6b00653. Epub 2016 Jul 1.

PMID:
27312113
11.

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.

Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC.

Science. 2008 Nov 21;322(5905):1211-7. doi: 10.1126/science.1164772. Epub 2008 Oct 2.

12.

Sodium ion binding pocket mutations and adenosine A2A receptor function.

Massink A, Gutiérrez-de-Terán H, Lenselink EB, Ortiz Zacarías NV, Xia L, Heitman LH, Katritch V, Stevens RC, IJzerman AP.

Mol Pharmacol. 2015 Feb;87(2):305-13. doi: 10.1124/mol.114.095737. Epub 2014 Dec 3.

13.

Structure of the adenosine A(2A) receptor bound to an engineered G protein.

Carpenter B, Nehmé R, Warne T, Leslie AG, Tate CG.

Nature. 2016 Aug 4;536(7614):104-7. Epub 2016 Jul 27.

14.

5'-Substituted Amiloride Derivatives as Allosteric Modulators Binding in the Sodium Ion Pocket of the Adenosine A2A Receptor.

Massink A, Louvel J, Adlere I, van Veen C, Huisman BJ, Dijksteel GS, Guo D, Lenselink EB, Buckley BJ, Matthews H, Ranson M, Kelso M, IJzerman AP.

J Med Chem. 2016 May 26;59(10):4769-77. doi: 10.1021/acs.jmedchem.6b00142. Epub 2016 May 10.

PMID:
27124340
15.

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.

Michino M, Abola E; GPCR Dock 2008 participants, Brooks CL 3rd, Dixon JS, Moult J, Stevens RC.

Nat Rev Drug Discov. 2009 Jun;8(6):455-63. doi: 10.1038/nrd2877. Review.

16.

Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space.

Jörg M, Shonberg J, Mak FS, Miller ND, Yuriev E, Scammells PJ, Capuano B.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3427-33. doi: 10.1016/j.bmcl.2013.03.070. Epub 2013 Apr 2.

PMID:
23602401
17.

Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine.

Doré AS, Robertson N, Errey JC, Ng I, Hollenstein K, Tehan B, Hurrell E, Bennett K, Congreve M, Magnani F, Tate CG, Weir M, Marshall FH.

Structure. 2011 Sep 7;19(9):1283-93. doi: 10.1016/j.str.2011.06.014.

18.

Purification and Crystallization of a Thermostabilized Agonist-Bound Conformation of the Human Adenosine A(2A) Receptor.

Tate CG, Lebon G.

Methods Mol Biol. 2015;1335:17-27. doi: 10.1007/978-1-4939-2914-6_2.

PMID:
26260591
19.

Adenosine A2A receptor as a drug discovery target.

de Lera Ruiz M, Lim YH, Zheng J.

J Med Chem. 2014 May 8;57(9):3623-50. doi: 10.1021/jm4011669. Epub 2013 Nov 15. Review.

PMID:
24164628
20.

The crystallographic structure of the human adenosine A2A receptor in a high-affinity antagonist-bound state: implications for GPCR drug screening and design.

Jaakola VP, Ijzerman AP.

Curr Opin Struct Biol. 2010 Aug;20(4):401-14. doi: 10.1016/j.sbi.2010.05.002. Epub 2010 Jun 9. Review.

PMID:
20538452

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