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Items: 1 to 20 of 64

1.
2.

Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer.

Abbotts R, Madhusudan S.

Cancer Treat Rev. 2010 Aug;36(5):425-35. doi: 10.1016/j.ctrv.2009.12.006. Epub 2010 Jan 6. Review.

PMID:
20056333
4.

A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells.

Jaiswal AS, Banerjee S, Panda H, Bulkin CD, Izumi T, Sarkar FH, Ostrov DA, Narayan S.

Mol Cancer Res. 2009 Dec;7(12):1973-83. doi: 10.1158/1541-7786.MCR-09-0309. Epub 2009 Dec 8.

5.

Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex.

Balakrishnan L, Brandt PD, Lindsey-Boltz LA, Sancar A, Bambara RA.

J Biol Chem. 2009 May 29;284(22):15158-72. doi: 10.1074/jbc.M109.000505. Epub 2009 Mar 27.

6.

A novel method for monitoring functional lesion-specific recruitment of repair proteins in live cells.

Woodrick J, Gupta S, Khatkar P, Dave K, Levashova D, Choudhury S, Elias H, Saha T, Mueller S, Roy R.

Mutat Res. 2015 May;775:48-58. doi: 10.1016/j.mrfmmm.2015.03.013. Epub 2015 Apr 4.

7.

Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma.

Xie J, Zhang L, Li M, Du J, Zhou L, Yang S, Zeng L, Li Z, Wang G, Wang D.

BMC Cancer. 2014 Jan 8;14:11. doi: 10.1186/1471-2407-14-11.

8.

Use of modified flap structures for study of base excision repair proteins.

Nazarkina ZhK, Pyshnyi DV, Pyshnaya IA, Lavrik OI, Khodyreva SN.

Biochemistry (Mosc). 2005 Dec;70(12):1327-34.

PMID:
16417454
9.

Long patch base excision repair compensates for DNA polymerase β inactivation by the C4'-oxidized abasic site.

Jacobs AC, Kreller CR, Greenberg MM.

Biochemistry. 2011 Jan 11;50(1):136-43. Epub 2010 Dec 14.

10.

Small-molecule inhibitors of APE1 DNA repair function: an overview.

Al-Safi RI, Odde S, Shabaik Y, Neamati N.

Curr Mol Pharmacol. 2012 Jan;5(1):14-35. Review.

PMID:
22122462
11.

Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites.

McNeill DR, Lam W, DeWeese TL, Cheng YC, Wilson DM 3rd.

Mol Cancer Res. 2009 Jun;7(6):897-906. doi: 10.1158/1541-7786.MCR-08-0519. Epub 2009 May 26.

12.

Is base excision repair a tumor suppressor mechanism?

Sweasy JB, Lang T, DiMaio D.

Cell Cycle. 2006 Feb;5(3):250-9. Epub 2006 Feb 14. Review.

PMID:
16418580
13.

A chemical and kinetic perspective on base excision repair of DNA.

Schermerhorn KM, Delaney S.

Acc Chem Res. 2014 Apr 15;47(4):1238-46. doi: 10.1021/ar400275a. Epub 2014 Mar 19.

14.

The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target.

Fishel ML, Kelley MR.

Mol Aspects Med. 2007 Jun-Aug;28(3-4):375-95. Epub 2007 May 3. Review.

PMID:
17560642
15.

Design and synthesis of 3-carbamoylbenzoic acid derivatives as inhibitors of human apurinic/apyrimidinic endonuclease 1 (APE1).

Aiello F, Shabaik Y, Esqueda A, Sanchez TW, Grande F, Garofalo A, Neamati N.

ChemMedChem. 2012 Oct;7(10):1825-39. doi: 10.1002/cmdc.201200334. Epub 2012 Sep 5.

PMID:
22952012
16.

Probing conformational changes in Ape1 during the progression of base excision repair.

Yu E, Gaucher SP, Hadi MZ.

Biochemistry. 2010 May 11;49(18):3786-96. doi: 10.1021/bi901828t.

PMID:
20377204
17.

A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways.

Prasad R, Beard WA, Batra VK, Liu Y, Shock DD, Wilson SH.

Mol Biol (Mosk). 2011 Jul-Aug;45(4):586-600. Review.

18.

Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors.

Zawahir Z, Dayam R, Deng J, Pereira C, Neamati N.

J Med Chem. 2009 Jan 8;52(1):20-32. doi: 10.1021/jm800739m.

PMID:
19072053
19.

Small molecule inhibitors of DNA repair nuclease activities of APE1.

Wilson DM 3rd, Simeonov A.

Cell Mol Life Sci. 2010 Nov;67(21):3621-31. doi: 10.1007/s00018-010-0488-2. Epub 2010 Aug 31. Review.

20.

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