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Items: 1 to 20 of 75

1.

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression.

Stallings-Mann ML, Waldmann J, Zhang Y, Miller E, Gauthier ML, Visscher DW, Downey GP, Radisky ES, Fields AP, Radisky DC.

Sci Transl Med. 2012 Jul 11;4(142):142ra95. doi: 10.1126/scitranslmed.3004062.

2.

Got a light? Illuminating lung cancer.

McAllister SS.

Sci Transl Med. 2012 Jul 11;4(142):142fs22. doi: 10.1126/scitranslmed.3004446.

PMID:
22786678
3.

Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition.

Lee K, Chen QK, Lui C, Cichon MA, Radisky DC, Nelson CM.

Mol Biol Cell. 2012 Oct;23(20):4097-108. doi: 10.1091/mbc.E12-02-0166. Epub 2012 Aug 23.

4.

Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma.

Mehner C, Miller E, Khauv D, Nassar A, Oberg AL, Bamlet WR, Zhang L, Waldmann J, Radisky ES, Crawford HC, Radisky DC.

Mol Cancer Res. 2014 Oct;12(10):1430-9. doi: 10.1158/1541-7786.MCR-13-0557-T. Epub 2014 May 21.

5.

Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing.

Pelisch F, Khauv D, Risso G, Stallings-Mann M, Blaustein M, Quadrana L, Radisky DC, Srebrow A.

J Cell Biochem. 2012 Jul;113(7):2319-29. doi: 10.1002/jcb.24103.

6.

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis.

Zhou C, Licciulli S, Avila JL, Cho M, Troutman S, Jiang P, Kossenkov AV, Showe LC, Liu Q, Vachani A, Albelda SM, Kissil JL.

Oncogene. 2013 Feb 14;32(7):903-9. doi: 10.1038/onc.2012.99. Epub 2012 Mar 19.

7.

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability.

Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, Werb Z, Bissell MJ.

Nature. 2005 Jul 7;436(7047):123-7.

8.

Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells.

Chen QK, Lee K, Radisky DC, Nelson CM.

Differentiation. 2013 Oct;86(3):126-32. doi: 10.1016/j.diff.2013.03.003. Epub 2013 May 6.

9.

Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

Kissil JL, Walmsley MJ, Hanlon L, Haigis KM, Bender Kim CF, Sweet-Cordero A, Eckman MS, Tuveson DA, Capobianco AJ, Tybulewicz VL, Jacks T.

Cancer Res. 2007 Sep 1;67(17):8089-94.

10.

Mechanisms of RhoGDI2 mediated lung cancer epithelial-mesenchymal transition suppression.

Niu H, Wu B, Jiang H, Li H, Zhang Y, Peng Y, He P.

Cell Physiol Biochem. 2014;34(6):2007-16. doi: 10.1159/000366396. Epub 2014 Nov 26.

11.

USP22 promotes tumor progression and induces epithelial-mesenchymal transition in lung adenocarcinoma.

Hu J, Yang D, Zhang H, Liu W, Zhao Y, Lu H, Meng Q, Pang H, Chen X, Liu Y, Cai L.

Lung Cancer. 2015 Jun;88(3):239-45. doi: 10.1016/j.lungcan.2015.02.019. Epub 2015 Mar 10.

PMID:
25907317
12.

Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells.

Saito RA, Watabe T, Horiguchi K, Kohyama T, Saitoh M, Nagase T, Miyazono K.

Cancer Res. 2009 Apr 1;69(7):2783-91. doi: 10.1158/0008-5472.CAN-08-3490. Epub 2009 Mar 17.

13.

Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.

Wislez M, Spencer ML, Izzo JG, Juroske DM, Balhara K, Cody DD, Price RE, Hittelman WN, Wistuba II, Kurie JM.

Cancer Res. 2005 Apr 15;65(8):3226-35.

14.
15.

PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.

Li X, Stevens PD, Liu J, Yang H, Wang W, Wang C, Zeng Z, Schmidt MD, Yang M, Lee EY, Gao T.

Gastroenterology. 2014 May;146(5):1301-12.e1-10. doi: 10.1053/j.gastro.2014.02.003. Epub 2014 Feb 11.

16.

TMEPAI regulates EMT in lung cancer cells by modulating the ROS and IRS-1 signaling pathways.

Hu Y, He K, Wang D, Yuan X, Liu Y, Ji H, Song J.

Carcinogenesis. 2013 Aug;34(8):1764-72. doi: 10.1093/carcin/bgt132. Epub 2013 Apr 24.

PMID:
23615405
17.

Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells.

Henriques AF, Barros P, Moyer MP, Matos P, Jordan P.

Cancer Lett. 2015 Dec 28;369(2):368-75. doi: 10.1016/j.canlet.2015.08.027. Epub 2015 Sep 1.

PMID:
26341689
18.

An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition.

Park CY, Min KN, Son JY, Park SY, Nam JS, Kim DK, Sheen YY.

Cancer Lett. 2014 Aug 28;351(1):72-80. doi: 10.1016/j.canlet.2014.05.006. Epub 2014 Jun 2.

PMID:
24887560
19.

Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition.

Arima Y, Inoue Y, Shibata T, Hayashi H, Nagano O, Saya H, Taya Y.

Cancer Res. 2008 Jul 1;68(13):5104-12. doi: 10.1158/0008-5472.CAN-07-5680.

20.

Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal transition.

Yuan XW, Wang DM, Hu Y, Tang YN, Shi WW, Guo XJ, Song JG.

J Biol Chem. 2013 Oct 25;288(43):31206-16. doi: 10.1074/jbc.M113.480285. Epub 2013 Sep 10.

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