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Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs.

Douglas IJ, Evans SJ, Hingorani AD, Grosso AM, Timmis A, Hemingway H, Smeeth L.

BMJ. 2012 Jul 10;345:e4388. doi: 10.1136/bmj.e4388.


Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopidogrel use: a nationwide cohort study.

Charlot M, Ahlehoff O, Norgaard ML, Jørgensen CH, Sørensen R, Abildstrøm SZ, Hansen PR, Madsen JK, Køber L, Torp-Pedersen C, Gislason G.

Ann Intern Med. 2010 Sep 21;153(6):378-86. doi: 10.7326/0003-4819-153-6-201009210-00005. Erratum in: Ann Intern Med. 2011 Jan 4;154(1):76.


A population-based study of the drug interaction between proton pump inhibitors and clopidogrel.

Juurlink DN, Gomes T, Ko DT, Szmitko PE, Austin PC, Tu JV, Henry DA, Kopp A, Mamdani MM.

CMAJ. 2009 Mar 31;180(7):713-8. doi: 10.1503/cmaj.082001. Epub 2009 Jan 28.


Impact of proton pump inhibitor therapy on the efficacy of clopidogrel in the CAPRIE and CREDO trials.

Dunn SP, Steinhubl SR, Bauer D, Charnigo RJ, Berger PB, Topol EJ.

J Am Heart Assoc. 2013 Jan 15;2(1):e004564. doi: 10.1161/JAHA.112.004564.


Review article: proton pump inhibitors with clopidogrel--evidence for and against a clinically-important interaction.

Disney BR, Watson RD, Blann AD, Lip GY, Anderson MR.

Aliment Pharmacol Ther. 2011 Apr;33(7):758-67. doi: 10.1111/j.1365-2036.2011.04585.x. Epub 2011 Feb 8. Review.


Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) registry.

Simon T, Steg PG, Gilard M, Blanchard D, Bonello L, Hanssen M, Lardoux H, Coste P, Lefèvre T, Drouet E, Mulak G, Bataille V, Ferrières J, Verstuyft C, Danchin N.

Circulation. 2011 Feb 8;123(5):474-82. doi: 10.1161/CIRCULATIONAHA.110.965640. Epub 2011 Jan 24.


Proton pump inhibitor use and risk of adverse cardiovascular events in aspirin treated patients with first time myocardial infarction: nationwide propensity score matched study.

Charlot M, Grove EL, Hansen PR, Olesen JB, Ahlehoff O, Selmer C, Lindhardsen J, Madsen JK, Køber L, Torp-Pedersen C, Gislason GH.

BMJ. 2011 May 11;342:d2690. doi: 10.1136/bmj.d2690.


Interaction between clopidogrel and proton pump inhibitors.

Friesen MH.

CMAJ. 2009 Jun 9;180(12):1228; author reply 1229. doi: 10.1503/cmaj.1090014. No abstract available.


Interaction between clopidogrel and proton pump inhibitors.

Allen MJ, McLean-Veysey P.

CMAJ. 2009 Jun 9;180(12):1228-9; author reply 1229. doi: 10.1503/cmaj.1090017. No abstract available.


Drug interaction between clopidogrel and proton pump inhibitors.

Liu TJ, Jackevicius CA.

Pharmacotherapy. 2010 Mar;30(3):275-89. doi: 10.1592/phco.30.3.275. Review.


Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials.

O'Donoghue ML, Braunwald E, Antman EM, Murphy SA, Bates ER, Rozenman Y, Michelson AD, Hautvast RW, Ver Lee PN, Close SL, Shen L, Mega JL, Sabatine MS, Wiviott SD.

Lancet. 2009 Sep 19;374(9694):989-97. doi: 10.1016/S0140-6736(09)61525-7. Epub 2009 Aug 31. Review.


Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study.

Ray WA, Murray KT, Griffin MR, Chung CP, Smalley WE, Hall K, Daugherty JR, Kaltenbach LA, Stein CM.

Ann Intern Med. 2010 Mar 16;152(6):337-45. doi: 10.7326/0003-4819-152-6-201003160-00003.


A comparison of aspirin and clopidogrel with or without proton pump inhibitors for the secondary prevention of cardiovascular events in patients at high risk for gastrointestinal bleeding.

Hsiao FY, Tsai YW, Huang WF, Wen YW, Chen PF, Chang PY, Kuo KN.

Clin Ther. 2009 Sep;31(9):2038-47. doi: 10.1016/j.clinthera.2009.09.005.


Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors.

Pezalla E, Day D, Pulliadath I.

J Am Coll Cardiol. 2008 Sep 16;52(12):1038-9; author reply 1039. doi: 10.1016/j.jacc.2008.05.053. No abstract available.


Prescribing proton pump inhibitors with clopidogrel.

Targownik LE.

BMJ. 2012 Jul 10;345:e4558. doi: 10.1136/bmj.e4558. No abstract available.


Drug interaction between clopidogrel and proton pump inhibitors.

Khalique SC, Cheng-Lai A.

Cardiol Rev. 2009 Jul-Aug;17(4):198-200. doi: 10.1097/CRD.0b013e3181a857ba. Review.


Effects of proton pump inhibitors on adverse gastrointestinal events in patients receiving clopidogrel: systematic review and meta-analysis.

Kwok CS, Nijjar RS, Loke YK.

Drug Saf. 2011 Jan 1;34(1):47-57. doi: 10.2165/11584750-000000000-00000. Review.


Concomitant administration of clopidogrel with statins or calcium-channel blockers: insights from the TRITON-TIMI 38 (trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-thrombolysis in myocardial infarction 38).

Ojeifo O, Wiviott SD, Antman EM, Murphy SA, Udell JA, Bates ER, Mega JL, Sabatine MS, O'Donoghue ML.

JACC Cardiovasc Interv. 2013 Dec;6(12):1275-81. doi: 10.1016/j.jcin.2013.06.014. Epub 2013 Nov 13.


Effect of the clopidogrel-proton pump inhibitor drug interaction on adverse cardiovascular events in patients with acute coronary syndrome.

Bhurke SM, Martin BC, Li C, Franks AM, Bursac Z, Said Q.

Pharmacotherapy. 2012 Sep;32(9):809-18. doi: 10.1002/j.1875-9114.2012.01112.x. Epub 2012 Jun 28.


Use of clopidogrel and proton pump inhibitors after a serious acute coronary event: risk of coronary events and peptic ulcer bleeding.

García Rodríguez LA, Johansson S, Cea Soriano L.

Thromb Haemost. 2013 Nov;110(5):1014-24. doi: 10.1160/TH13-03-0225. Epub 2013 Jul 25.


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