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Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.

De Jonghe BC, Hayes MR, Zimmer DJ, Kanoski SE, Grill HJ, Bence KK.

Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E644-51. doi: 10.1152/ajpendo.00009.2012. Epub 2012 Jul 3.


Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.

De Jonghe BC, Hayes MR, Banno R, Skibicka KP, Zimmer DJ, Bowen KA, Leichner TM, Alhadeff AL, Kanoski SE, Cyr NE, Nillni EA, Grill HJ, Bence KK.

Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1002-11. doi: 10.1152/ajpendo.00639.2010. Epub 2011 Mar 15.


Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons.

do Carmo JM, da Silva AA, Rushing JS, Pace B, Hall JE.

Am J Physiol Regul Integr Comp Physiol. 2013 Aug 15;305(4):R359-68. doi: 10.1152/ajpregu.00518.2012. Epub 2013 Jul 10.


PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice.

Banno R, Zimmer D, De Jonghe BC, Atienza M, Rak K, Yang W, Bence KK.

J Clin Invest. 2010 Mar;120(3):720-34. doi: 10.1172/JCI39620. Epub 2010 Feb 15.


Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension.

Bruder-Nascimento T, Butler BR, Herren DJ, Brands MW, Bence KK, Belin de Chantemèle EJ.

Pharmacol Res. 2015 Dec;102:235-44. doi: 10.1016/j.phrs.2015.10.012. Epub 2015 Oct 30.


Energetic responses are triggered by caudal brainstem melanocortin receptor stimulation and mediated by local sympathetic effector circuits.

Skibicka KP, Grill HJ.

Endocrinology. 2008 Jul;149(7):3605-16. doi: 10.1210/en.2007-1754. Epub 2008 Mar 27.


NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation.

Campos CA, Ritter RC.

Am J Physiol Regul Integr Comp Physiol. 2015 Jan 1;308(1):R1-9. doi: 10.1152/ajpregu.00388.2014. Epub 2014 Nov 12.


Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonist.

Campos CA, Shiina H, Ritter RC.

J Neurosci. 2014 Sep 17;34(38):12636-45. doi: 10.1523/JNEUROSCI.1121-14.2014.


The orexigenic activity of the hypothalamic neuropeptide 26RFa is mediated by the neuropeptide Y and proopiomelanocortin neurons of the arcuate nucleus.

Lectez B, Jeandel L, El-Yamani FZ, Arthaud S, Alexandre D, Mardargent A, Jégou S, Mounien L, Bizet P, Magoul R, Anouar Y, Chartrel N.

Endocrinology. 2009 May;150(5):2342-50. doi: 10.1210/en.2008-1432. Epub 2009 Jan 22.


Ptp1b deletion in pro-opiomelanocortin neurons increases energy expenditure and impairs endothelial function via TNF-α dependent mechanisms.

Bruder-Nascimento T, Kennard S, Antonova G, Mintz JD, Bence KK, Belin de Chantemèle EJ.

Clin Sci (Lond). 2016 Jun 1;130(11):881-93. doi: 10.1042/CS20160073. Epub 2016 Mar 2.


Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections.

Zheng H, Patterson LM, Phifer CB, Berthoud HR.

Am J Physiol Regul Integr Comp Physiol. 2005 Jul;289(1):R247-58. Epub 2005 Mar 3.


Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice.

Tsou RC, Zimmer DJ, De Jonghe BC, Bence KK.

Endocrinology. 2012 Sep;153(9):4227-37. doi: 10.1210/en.2012-1548. Epub 2012 Jul 16.


Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons.

Kublaoui BM, Holder JL Jr, Gemelli T, Zinn AR.

Mol Endocrinol. 2006 Oct;20(10):2483-92. Epub 2006 May 25.


Pancreatic neuronal melanocortin-4 receptor modulates serum insulin levels independent of leptin receptor.

Mansour M, White D, Wernette C, Dennis J, Tao YX, Collins R, Parker L, Morrison E.

Endocrine. 2010 Feb;37(1):220-30. doi: 10.1007/s12020-009-9289-5. Epub 2010 Jan 7.


Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice.

Chiappini F, Catalano KJ, Lee J, Peroni OD, Lynch J, Dhaneshwar AS, Wellenstein K, Sontheimer A, Neel BG, Kahn BB.

J Clin Invest. 2014 Sep;124(9):3781-92. doi: 10.1172/JCI68585. Epub 2014 Aug 1.


Pituitary adenylate cyclase-activating polypeptide inhibits food intake in mice through activation of the hypothalamic melanocortin system.

Mounien L, Do Rego JC, Bizet P, Boutelet I, Gourcerol G, Fournier A, Brabet P, Costentin J, Vaudry H, Jégou S.

Neuropsychopharmacology. 2009 Jan;34(2):424-35. doi: 10.1038/npp.2008.73. Epub 2008 Jun 4.


A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake.

Zheng H, Patterson LM, Rhodes CJ, Louis GW, Skibicka KP, Grill HJ, Myers MG Jr, Berthoud HR.

Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R720-8. doi: 10.1152/ajpregu.00619.2009. Epub 2010 Jan 13.


Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors.

Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly S, Heisler LK.

Endocrinology. 2008 Mar;149(3):1323-8. Epub 2007 Nov 26.

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