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Amino acids and mTORC1: from lysosomes to disease.

Efeyan A, Zoncu R, Sabatini DM.

Trends Mol Med. 2012 Sep;18(9):524-33. doi: 10.1016/j.molmed.2012.05.007. Epub 2012 Jun 28. Review.


Regulation of mTORC1 by amino acids.

Bar-Peled L, Sabatini DM.

Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31. Review.


SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

Rebsamen M, Pochini L, Stasyk T, de Ara├║jo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G.

Nature. 2015 Mar 26;519(7544):477-81. doi: 10.1038/nature14107. Epub 2015 Jan 7.


Amino acid signalling upstream of mTOR.

Jewell JL, Russell RC, Guan KL.

Nat Rev Mol Cell Biol. 2013 Mar;14(3):133-9. doi: 10.1038/nrm3522. Epub 2013 Jan 30. Review.


Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.

Schweitzer LD, Comb WC, Bar-Peled L, Sabatini DM.

Cell Rep. 2015 Sep 1;12(9):1445-55. doi: 10.1016/j.celrep.2015.07.052. Epub 2015 Aug 20.


Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids.

Averous J, Lambert-Langlais S, Carraro V, Gourbeyre O, Parry L, B'Chir W, Muranishi Y, Jousse C, Bruhat A, Maurin AC, Proud CG, Fafournoux P.

Cell Signal. 2014 Sep;26(9):1918-27. doi: 10.1016/j.cellsig.2014.04.019. Epub 2014 May 2.


Rheb and Rags come together at the lysosome to activate mTORC1.

Groenewoud MJ, Zwartkruis FJ.

Biochem Soc Trans. 2013 Aug;41(4):951-5. doi: 10.1042/BST20130037. Review.


mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.

Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM.

Science. 2011 Nov 4;334(6056):678-83. doi: 10.1126/science.1207056.


Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.

Jung J, Genau HM, Behrends C.

Mol Cell Biol. 2015 Jul;35(14):2479-94. doi: 10.1128/MCB.00125-15. Epub 2015 May 11.


Key mediators of intracellular amino acids signaling to mTORC1 activation.

Duan Y, Li F, Tan K, Liu H, Li Y, Liu Y, Kong X, Tang Y, Wu G, Yin Y.

Amino Acids. 2015 May;47(5):857-67. doi: 10.1007/s00726-015-1937-x. Epub 2015 Feb 21. Review.


Rag GTPase in amino acid signaling.

Kim J, Kim E.

Amino Acids. 2016 Apr;48(4):915-28. doi: 10.1007/s00726-016-2171-x. Epub 2016 Jan 18. Review.


The amino acid transporter SLC38A9 regulates MTORC1 and autophagy.

Jin M, Klionsky DJ.

Autophagy. 2015;11(10):1709-10. doi: 10.1080/15548627.2015.1084461.


Current models of mammalian target of rapamycin complex 1 (mTORC1) activation by growth factors and amino acids.

Zheng X, Liang Y, He Q, Yao R, Bao W, Bao L, Wang Y, Wang Z.

Int J Mol Sci. 2014 Nov 13;15(11):20753-69. doi: 10.3390/ijms151120753. Review.


Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism.

Dyachok J, Earnest S, Iturraran EN, Cobb MH, Ross EM.

J Biol Chem. 2016 Oct 21;291(43):22414-22426. Epub 2016 Sep 1.


Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM.

Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.


Metabolism. Differential regulation of mTORC1 by leucine and glutamine.

Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL.

Science. 2015 Jan 9;347(6218):194-8. doi: 10.1126/science.1259472. Epub 2015 Jan 7.


Nutrient signaling to mTOR and cell growth.

Jewell JL, Guan KL.

Trends Biochem Sci. 2013 May;38(5):233-42. doi: 10.1016/j.tibs.2013.01.004. Epub 2013 Mar 1. Review.


Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly.

Stransky LA, Forgac M.

J Biol Chem. 2015 Nov 6;290(45):27360-9. doi: 10.1074/jbc.M115.659128. Epub 2015 Sep 16.


Nutrient regulation of the mTOR complex 1 signaling pathway.

Kim SG, Buel GR, Blenis J.

Mol Cells. 2013 Jun;35(6):463-73. doi: 10.1007/s10059-013-0138-2. Epub 2013 May 20. Review.


The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.

Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM.

Cell Rep. 2014 Oct 9;9(1):1-8. doi: 10.1016/j.celrep.2014.09.014. Epub 2014 Sep 25.

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